ID   DIF1_ASHGO              Reviewed;         194 AA.
AC   Q756Z2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; OrderedLocusNames=AER122C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Mediates the nuclear localization of the ribonucleotide
CC       reductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS52805.1; -; Genomic_DNA.
DR   RefSeq; NP_984981.1; NM_210335.1.
DR   AlphaFoldDB; Q756Z2; -.
DR   SMR; Q756Z2; -.
DR   EnsemblFungi; AAS52805; AAS52805; AGOS_AER122C.
DR   GeneID; 4621187; -.
DR   KEGG; ago:AGOS_AER122C; -.
DR   eggNOG; ENOG502SG7B; Eukaryota.
DR   HOGENOM; CLU_121023_0_0_1; -.
DR   InParanoid; Q756Z2; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990846; F:ribonucleoside-diphosphate reductase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:1905117; P:regulation of ribonucleoside-diphosphate reductase activity; IBA:GO_Central.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   PANTHER; PTHR28081; PTHR28081; 1.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..194
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399010"
FT   REGION          34..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  21858 MW;  D5CB37FB52981B9D CRC64;
     MCLYVNKEHP YTQASGPWPA CLPRRWQLYK DQRRLHRPGG RRPMSTSDSH LGSPRKRQLQ
     RAAPAAPQHS EYQQQLSTLG MRIRQAVDNG YRAPQDPVRA AVPHAVPAAA CVQDNTLYTV
     PDYKRVPLAA DRAPPMLVNQ RTVSSTSSLQ AWESQLDERL SLIDSSIMHN KLGAGEFMLG
     GTKRAFDQLE TDNW