ID   DIF1_CAEEL              Reviewed;         312 AA.
AC   Q27257; Q20630;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Protein dif-1;
GN   Name=dif-1; ORFNames=F49E8.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7803813; DOI=10.3109/10425179409020854;
RA   Runswick M.J., Philippides A., Lauria G., Walker J.E.;
RT   "Extension of the mitochondrial transporter super-family: sequences of five
RT   members from the nematode worm, Caenorhabditis elegans.";
RL   DNA Seq. 4:281-291(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7774589; DOI=10.1002/j.1460-2075.1995.tb07225.x;
RA   Ahringer J.;
RT   "Embryonic tissue differentiation in Caenorhabditis elegans requires dif-1,
RT   a gene homologous to mitochondrial solute carriers.";
RL   EMBO J. 14:2307-2316(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Seems to play a role in the maintenance of tissue
CC       differentiation in the developing embryo, but not for its initiation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Although dif-1 activity is required only during
CC       embryogenesis, it is expressed at all stages of development.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X76115; CAA53721.1; -; mRNA.
DR   EMBL; Z48240; CAA88283.1; -; Genomic_DNA.
DR   EMBL; FO081280; CCD70447.1; -; Genomic_DNA.
DR   PIR; T29640; T29640.
DR   RefSeq; NP_501223.1; NM_068822.5.
DR   AlphaFoldDB; Q27257; -.
DR   SMR; Q27257; -.
DR   BioGRID; 42648; 21.
DR   IntAct; Q27257; 1.
DR   STRING; 6239.F49E8.5.2; -.
DR   TCDB; 2.A.29.8.2; the mitochondrial carrier (mc) family.
DR   EPD; Q27257; -.
DR   PaxDb; Q27257; -.
DR   PeptideAtlas; Q27257; -.
DR   EnsemblMetazoa; F49E8.5.1; F49E8.5.1; WBGene00000996.
DR   EnsemblMetazoa; F49E8.5.2; F49E8.5.2; WBGene00000996.
DR   GeneID; 177530; -.
DR   UCSC; F49E8.5.1; c. elegans.
DR   CTD; 177530; -.
DR   WormBase; F49E8.5; CE28408; WBGene00000996; dif-1.
DR   eggNOG; KOG0758; Eukaryota.
DR   GeneTree; ENSGT00940000167609; -.
DR   HOGENOM; CLU_015166_16_0_1; -.
DR   InParanoid; Q27257; -.
DR   OMA; QYTIGQI; -.
DR   OrthoDB; 1072378at2759; -.
DR   PhylomeDB; Q27257; -.
DR   Reactome; R-CEL-200425; Carnitine metabolism.
DR   PRO; PR:Q27257; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00000996; Expressed in embryo and 6 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005740; C:mitochondrial envelope; IMP:UniProtKB.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015227; F:acyl carnitine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1902603; P:carnitine transmembrane transport; IBA:GO_Central.
DR   GO; GO:0140021; P:mitochondrial ADP transmembrane transport; IEA:InterPro.
DR   GO; GO:1990544; P:mitochondrial ATP transmembrane transport; IEA:InterPro.
DR   GO; GO:0006839; P:mitochondrial transport; IMP:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 2.
DR   InterPro; IPR002113; ADT_euk_type.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00927; ADPTRNSLCASE.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..312
FT                   /note="Protein dif-1"
FT                   /id="PRO_0000090693"
FT   TRANSMEM        5..25
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..282
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2..93
FT                   /note="Solcar 1"
FT   REPEAT          102..193
FT                   /note="Solcar 2"
FT   REPEAT          203..289
FT                   /note="Solcar 3"
SQ   SEQUENCE   312 AA;  33135 MW;  CCF1300CAE4DF64F CRC64;
     MSDVLLNFIA GGVGGSCTVI VGHPFDTVKV RIQTMPMPKP GEKPQFTGAL DCVKRTVSKE
     GFFALYKGMA APLVGVSPLF AVFFGGCAVG KWLQQTDPSQ EMTFIQNANA GALAGVFTTI
     VMVPGERIKC LLQVQQAGSA GSGVHYDGPL DVVKKLYKQG GISSIYRGTG ATLLRDIPAS
     AAYLSVYEYL KKKFSGEGAQ RTLSPGATLM AGGLAGIANW GVCIPADVLK SRLQTAPEGK
     YPDGIRGVLR EVLREEGPRA LFKGFWPVML RAFPANAACF FGLELTLAAF RYFGIGGHPT
     PSTEVVPLPH DE