ID   DIF1_KLULA              Reviewed;         158 AA.
AC   Q6CWB2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; OrderedLocusNames=KLLA0B05423g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mediates the nuclear localization of the ribonucleotide
CC       reductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02170.1; -; Genomic_DNA.
DR   RefSeq; XP_451777.1; XM_451777.1.
DR   AlphaFoldDB; Q6CWB2; -.
DR   EnsemblFungi; CAH02170; CAH02170; KLLA0_B05423g.
DR   GeneID; 2897253; -.
DR   KEGG; kla:KLLA0_B05423g; -.
DR   eggNOG; ENOG502SG7B; Eukaryota.
DR   HOGENOM; CLU_121023_0_0_1; -.
DR   InParanoid; Q6CWB2; -.
DR   OMA; INQRTMS; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..158
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399012"
SQ   SEQUENCE   158 AA;  17429 MW;  074CFDE1B5C1FCE0 CRC64;
     MTVSSQSPVK KQLHNAIQPS NGQYEYHDKL STLGMRIRQA VDNGYQGVSV HNTANNTIAA
     TSGSNGSNSS INGAGFSNIC VQDNTRFTIP EYKRVALAKQ PPMLVNQRTV SMNSNLEQWE
     QNLDQRLSSI DDDIMRNKLG ASDFLSGASK RSFDDLEF