ID   DIF1_LACTC              Reviewed;         128 AA.
AC   C5DFL1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; OrderedLocusNames=KLTH0D16016g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Mediates the nuclear localization of the ribonucleotide
CC       reductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; CU928168; CAR22966.1; -; Genomic_DNA.
DR   RefSeq; XP_002553404.1; XM_002553358.1.
DR   AlphaFoldDB; C5DFL1; -.
DR   EnsemblFungi; CAR22966; CAR22966; KLTH0D16016g.
DR   GeneID; 8295651; -.
DR   KEGG; lth:KLTH0D16016g; -.
DR   eggNOG; ENOG502SG7B; Eukaryota.
DR   HOGENOM; CLU_121023_0_0_1; -.
DR   InParanoid; C5DFL1; -.
DR   OMA; INQRTMS; -.
DR   OrthoDB; 1497044at2759; -.
DR   Proteomes; UP000002036; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   PANTHER; PTHR28081; PTHR28081; 1.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..128
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399013"
FT   REGION          70..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   128 AA;  14410 MW;  53544D198DFB1C05 CRC64;
     MTESPQKRHL GQGIERQNEQ YACQGALSTI GMRIRQSVDR GYQVSGAAPA PAARTAASCV
     QDNSELTIPD YKRVPMPSSK QAPMLVNSRT VSSSSSLEMW ENQLDERLEH IDNDIMRNKR
     AFEQVEDW