ID   DIF1_YEAS1              Reviewed;         133 AA.
AC   B3RHU5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; ORFNames=SCRG_04374;
OS   Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=285006;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM11-1a;
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Cuomo C.,
RA   Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA   Mauceli E.W., Brockman W., MacCallum I.A., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   O'Leary S., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Pratt S.,
RA   Kruglyak L.;
RT   "Annotation of the Saccharomyces cerevisiae RM11-1a genome.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the nuclear localization of RNR2 and RNR4, 2
CC       subunits of the ribonucleotide reductase. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RNR2 and RNR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by DUN1 in response to DNA damage which leads to
CC       its degradation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; DS981519; EDV08739.1; -; Genomic_DNA.
DR   AlphaFoldDB; B3RHU5; -.
DR   SMR; B3RHU5; -.
DR   EnsemblFungi; EDV08739; EDV08739; SCRG_04374.
DR   HOGENOM; CLU_1887371_0_0_1; -.
DR   Proteomes; UP000008335; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   PANTHER; PTHR28081; PTHR28081; 1.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..133
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399014"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  15135 MW;  14CC76C644D48979 CRC64;
     MDAQLEWASS LVPKRQLQQQ QQQQEQQQQQ QQDFHKDQLM TVGMRIRQRV DQGYASRTPS
     TSDASLQPGV IRDYSSVIVP QFTRSPLPTA NSLPPMLINQ RTMSTEASSL EKWDVAEPAA
     EHEAMVNGSK RRL