ID   DIF1_YEAS2              Reviewed;         132 AA.
AC   C7GSL9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; ORFNames=C1Q_03365;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA   Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA   Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA   Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA   Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: Mediates the nuclear localization of RNR2 and RNR4, 2
CC       subunits of the ribonucleotide reductase. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RNR2 and RNR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by DUN1 in response to DNA damage which leads to
CC       its degradation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; ACFL01000194; EEU06195.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7GSL9; -.
DR   SMR; C7GSL9; -.
DR   Proteomes; UP000008073; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   PANTHER; PTHR28081; PTHR28081; 1.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..132
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399015"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   132 AA;  15007 MW;  5615D8CC08B0E8C5 CRC64;
     MDAQLEWASS LVPKRQLQQQ QQQEQQQQQQ QDFHKDQLMT VGMRIRQRVD QGYASRTPST
     SDASLQPGVI RDYSSVIVPQ FTRSPLPTAN SLPPMLINQR TMSTEASSLE KWDVAEPAAE
     HEAMVNGSKR RL