DIF1_YEAS7
ID DIF1_YEAS7 Reviewed; 131 AA.
AC A7A1V6;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Damage-regulated import facilitator 1;
GN Name=DIF1; ORFNames=SCY_3984;
OS Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=307796;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJM789;
RX PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA Steinmetz L.M.;
RT "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT strain YJM789.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC -!- FUNCTION: Mediates the nuclear localization of RNR2 and RNR4, 2
CC subunits of the ribonucleotide reductase. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RNR2 and RNR4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- PTM: Phosphorylated by DUN1 in response to DNA damage which leads to
CC its degradation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR EMBL; AAFW02000171; EDN59334.1; -; Genomic_DNA.
DR AlphaFoldDB; A7A1V6; -.
DR SMR; A7A1V6; -.
DR EnsemblFungi; EDN59334; EDN59334; SCY_3984.
DR HOGENOM; CLU_1887371_0_0_1; -.
DR Proteomes; UP000007060; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR013900; RNR_inhibitor.
DR PANTHER; PTHR28081; PTHR28081; 1.
DR Pfam; PF08591; RNR_inhib; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Phosphoprotein.
FT CHAIN 1..131
FT /note="Damage-regulated import facilitator 1"
FT /id="PRO_0000399016"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 131 AA; 14909 MW; 996BC8E6FD8411A3 CRC64;
MDAQLEWASS LVPKRQLQQQ QQQEQQQQQQ DFHKDQLMTV GMRIRQRVDQ GYASRTPSTS
DASLQPGVIR DYSSVIVPQF TRSPLPTANS LPPMLINQRT MSTEASSLEK WDVAEPAAEH
ETMVNGSKRR L