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DIF1_YEAS7
ID   DIF1_YEAS7              Reviewed;         131 AA.
AC   A7A1V6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; ORFNames=SCY_3984;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Mediates the nuclear localization of RNR2 and RNR4, 2
CC       subunits of the ribonucleotide reductase. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RNR2 and RNR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by DUN1 in response to DNA damage which leads to
CC       its degradation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000171; EDN59334.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7A1V6; -.
DR   SMR; A7A1V6; -.
DR   EnsemblFungi; EDN59334; EDN59334; SCY_3984.
DR   HOGENOM; CLU_1887371_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   PANTHER; PTHR28081; PTHR28081; 1.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..131
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399016"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   131 AA;  14909 MW;  996BC8E6FD8411A3 CRC64;
     MDAQLEWASS LVPKRQLQQQ QQQEQQQQQQ DFHKDQLMTV GMRIRQRVDQ GYASRTPSTS
     DASLQPGVIR DYSSVIVPQF TRSPLPTANS LPPMLINQRT MSTEASSLEK WDVAEPAAEH
     ETMVNGSKRR L
 
 
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