ID   DIF1_YEAS8              Reviewed;         133 AA.
AC   C8ZE43;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Damage-regulated import facilitator 1;
GN   Name=DIF1; ORFNames=EC1118_1L7_3213g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Mediates the nuclear localization of RNR2 and RNR4, 2
CC       subunits of the ribonucleotide reductase. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RNR2 and RNR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by DUN1 in response to DNA damage which leads to
CC       its degradation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIF1/spd1 family. {ECO:0000305}.
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DR   EMBL; FN393080; CAY81659.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8ZE43; -.
DR   SMR; C8ZE43; -.
DR   EnsemblFungi; CAY81659; CAY81659; EC1118_1L7_3213g.
DR   HOGENOM; CLU_1887371_0_0_1; -.
DR   Proteomes; UP000000286; Chromosome XII, Scaffold EC1118_1L7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013900; RNR_inhibitor.
DR   PANTHER; PTHR28081; PTHR28081; 1.
DR   Pfam; PF08591; RNR_inhib; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Phosphoprotein.
FT   CHAIN           1..133
FT                   /note="Damage-regulated import facilitator 1"
FT                   /id="PRO_0000399017"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..37
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  15135 MW;  14CC76C644D48979 CRC64;
     MDAQLEWASS LVPKRQLQQQ QQQQEQQQQQ QQDFHKDQLM TVGMRIRQRV DQGYASRTPS
     TSDASLQPGV IRDYSSVIVP QFTRSPLPTA NSLPPMLINQ RTMSTEASSL EKWDVAEPAA
     EHEAMVNGSK RRL