DIG1_CAEEL
ID DIG1_CAEEL Reviewed; 13100 AA.
AC Q09165; Q8MTB9;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Mesocentin;
DE Flags: Precursor;
GN Name=dig-1; ORFNames=K07E12.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RA Proenca R.B., Hedgecock E.M.;
RT "Evolution and developmental functions of mesocentin - a novel
RT Caenorhabditis elegans extracellular matrix protein.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION.
RA Burket C., Higgins C.E., Hull L.C., Hubbard S., Berninsone P., Ryder E.F.;
RT "The C. elegans gene dig-1 encodes a novel adhesion molecule of the
RT immunoglobulin superfamily that functions during sensory process
RT development in the nervous system.";
RL Unpublished observations (APR-2006).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-518 AND ASN-575, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15888633; DOI=10.1093/glycob/cwi075;
RA Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J.;
RT "Identification of the hydrophobic glycoproteins of Caenorhabditis
RT elegans.";
RL Glycobiology 15:952-964(2005).
RN [5]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-324; ASN-384; ASN-518; ASN-575;
RP ASN-841; ASN-12294; ASN-12478 AND ASN-12843, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- FUNCTION: Encodes an adhesion molecule involved in sensory map
CC formation. Functions during sensory process development in the nervous
CC system. {ECO:0000269|Ref.3}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000269|Ref.1}.
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DR EMBL; AY117398; AAM78593.1; -; mRNA.
DR EMBL; FO081605; CCD72779.1; -; Genomic_DNA.
DR PIR; T16580; T16580.
DR RefSeq; NP_741200.1; NM_171172.3.
DR BioGRID; 41166; 2.
DR STRING; 6239.K07E12.1a.1; -.
DR iPTMnet; Q09165; -.
DR EPD; Q09165; -.
DR PaxDb; Q09165; -.
DR PeptideAtlas; Q09165; -.
DR PRIDE; Q09165; -.
DR UCSC; K07E12.1a.1; c. elegans.
DR WormBase; K07E12.1a; CE32905; WBGene00000998; dig-1.
DR eggNOG; KOG4221; Eukaryota.
DR HOGENOM; CLU_000012_0_0_1; -.
DR InParanoid; Q09165; -.
DR OMA; THANCAR; -.
DR OrthoDB; 1352575at2759; -.
DR PhylomeDB; Q09165; -.
DR PRO; PR:Q09165; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000998; Expressed in anatomical system and 4 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0071711; P:basement membrane organization; IMP:WormBase.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0008406; P:gonad development; IMP:WormBase.
DR GO; GO:0007399; P:nervous system development; IMP:WormBase.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; -; 15.
DR Gene3D; 3.40.50.410; -; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00041; fn3; 9.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF00092; VWA; 3.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00060; FN3; 11.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 6.
DR SMART; SM00327; VWA; 4.
DR SUPFAM; SSF48726; SSF48726; 5.
DR SUPFAM; SSF49265; SSF49265; 6.
DR SUPFAM; SSF50952; SSF50952; 16.
DR SUPFAM; SSF53300; SSF53300; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50853; FN3; 11.
DR PROSITE; PS50835; IG_LIKE; 7.
DR PROSITE; PS50234; VWFA; 4.
PE 1: Evidence at protein level;
KW Cell adhesion; Developmental protein; Disulfide bond; EGF-like domain;
KW Extracellular matrix; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Repeat; Secreted; Signal; Sushi.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..13100
FT /note="Mesocentin"
FT /id="PRO_0000233334"
FT DOMAIN 162..222
FT /note="Sushi"
FT DOMAIN 225..263
FT /note="EGF-like 1"
FT DOMAIN 305..392
FT /note="Ig-like C2-type 1"
FT DOMAIN 394..491
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 491..577
FT /note="Ig-like C2-type 2"
FT DOMAIN 580..678
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 681..778
FT /note="Ig-like C2-type 3"
FT DOMAIN 782..879
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 892..983
FT /note="Ig-like C2-type 4"
FT DOMAIN 994..1092
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1097..1199
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1203..1280
FT /note="Ig-like C2-type 5"
FT DOMAIN 1287..1384
FT /note="Fibronectin type-III 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1385..1493
FT /note="Fibronectin type-III 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1500..1576
FT /note="Ig-like C2-type 6"
FT DOMAIN 1585..1697
FT /note="Fibronectin type-III 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1702..1806
FT /note="Fibronectin type-III 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1810..1904
FT /note="Ig-like C2-type 7"
FT DOMAIN 2007..2100
FT /note="Fibronectin type-III 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 6599..6787
FT /note="VWFA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 12167..12341
FT /note="VWFA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 12379..12557
FT /note="VWFA 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 12609..12780
FT /note="VWFA 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 12816..12910
FT /note="Fibronectin type-III 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 12988..13029
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255"
FT REGION 2172..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2339..2438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2729..2748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2759..2787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2905..2933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3128..3254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3347..3389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3430..3455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3764..3787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3923..3967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4001..4030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4350..4386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5072..5091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5137..5157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5187..5252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5310..5349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5467..5492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5615..5640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5691..5714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5797..5862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6189..6212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6240..6266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6294..6324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6364..6427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6443..6469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6548..6581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6927..7029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7129..7149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7406..7427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7674..7733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7780..7801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7813..7875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7896..7920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8034..8060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8180..8201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8407..8521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8663..8689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8701..8720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8890..8912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8933..8959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9041..9063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9078..9104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9186..9206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9224..9249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9463..9570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9666..9688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9943..9964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10170..10284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10317..10338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10385..10404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10655..10696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 10801..10862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11362..11419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11474..11493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11617..11636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 11670..11711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2196..2213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2353
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2360..2378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2379..2401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3134..3150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3230..3254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4001..4015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5846..5862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6559..6577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6942..6956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6957..6971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7407..7427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7676..7690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8181..8201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8435..8449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8450..8464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9479..9493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9494..9508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9944..9964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10198..10212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10213..10227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10830..10862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11671..11699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 384
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 518
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 575
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 841
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 931
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1211
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1399
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1612
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1840
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1879
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1898
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8810
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10555
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10570
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 12478
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 12840
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12843
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 12895
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12913
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 193..220
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 327..374
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 517..561
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 705..762
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1226..1264
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1523..1562
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 1839..1888
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 13100 AA; 1373302 MW; E13DCBF28C7EA6FE CRC64;
MGGRNWLFRS AVLVSTLLTC ISIAQELLPS IEVESLAQDL QIQEWMRTLR RVKRAPTRNN
RPEPVVVGRN GTGKCVISAD RASHFCGMEE EVSAPPIPPP DEGKCIISKA SGREICYPSY
SQLDTSCTDV TGQSSNGLVV PPVVPHATVR AMAFVPPDNL RRLIIQYYRQ QGKHQPKNAT
FSPKSFLFVK YHCDYGYEMV DEVDTMFCQD KKWVMTPPMC RGQGLCAADN GGCSHTCISY
NDEKIECKCP RGMTLDVDEK TCIKPIPKSL CRSLSGCTCN GITETQFACS CGDNKQKCLL
IAGPPRIYIE PQGPYEVAPG GNINISCTSV AYPFPDIYWF KNQKVNTDGP DQNTLRASQI
LIIKEIYRNE EFTCVSDNIH GSANRTVSIV VTGPGSAPHL KSASAGRTSL TVRWEPPSII
NRPITTYTLY YTNNPQQPVK NWKKLEVKEP TREVAIPDLR PDTAYYIRVR ANDPLGPGKL
GNQVQIKTLK PAVRPYVNIV EGDEIRVPPM TAFEIDCNVT RADPVPVLVW LHKGRPLNKG
SKTQHIKMKN GGVLESTQFS CVAENEAGKS TKKINVTVTG PSAPERIRYQ IDGDKVTLQW
EPPQITNGPM AGYDVFYTED PSLPRDQWKV HHIDDPNART TTVLRLNEKT PYTFVIVGRN
RLGPGLPSAP FTATTWLAAK PPVVQLEPSE EMTKEPSNDE MIIECGAQGV PKPKIIWLWS
GTLIEDGKEE FRVYDTTPTD AQDRTRSKLI AQSTTRSGVA TCQAVNSEGS DEKKVPVKIL
GPGSAPLGIT PTPMHTGFDV AWKPPKVTNG RITDYVVYYS KDPDAPLSDW ESKTVPADTR
NLTVNVDDED TPYVVKVQAR TDDGPGIISE AYEVTTGRKQ VPLSVRLEIA DPSVDPSTGE
TIVEPTQPIH FRCVADGRPM PSVSYSWLPI NASESGDEPV PIPIHSDDSQ PHHYNSIQVY
STTATKRILL CQARNPDGTV DDRHVFIVNK PGSAPQNPEV IVDPDNRVTI TWQPPKYPNG
EITSYNVYIT GDPSLPVDQW QVFPVDDVTD PKLVLQRGAL QPETPYFVKI AAVNPHGEGI
HTDPKHFDTV SGAPIDAPTD VLPSVSIDNT VNITWSPPTQ PLGPIKSYTV YFAPEYDDSD
FKTWQRISVD APDGADHGEV TLPKEQFNPN TPYKIRISAT NDLSEGPASD PVRFETGSGE
IPPTITLDPS NSTYTVEPLG AATITCTATG VPQPKVHWIK ANGETVDSAT LQLYDLVKDT
SATCVAENNA GKTQEAVSIQ VTGPGTAPNE IVLLPMPNQE INVEWTSPDE VNGQITNYII
HYGEISEDGS EPATWDQVTI ARDDVNHKLA NLEPKKTYAI RVQAVSDRGP GVISAPQVIK
TLPLAPQAIT NPIIQVHPNN SVTIEFTPPD DPENPGKKVK DFVIQYTTDE EPDDESVWKE
LKFTDPDDTD DTTIVSIDGE NFNPDTKYNT RIIARGEIDS QPNEPTLFAT GDGVIAPSQP
SFNVDTEDGV IRVPAGTDYT IKCVSEGYPA PDVRWVDSHG NQLSDGPLLR IIDIRKTLNA
KCLAENRGGL KETDLTIFVA GPGTAPENIQ LTANKPTTIS VQYEVPSIPN GNISKYIIYY
TPLDDQDPDH QLGQVQTKPI SDWQNVHDMN DGVEGPRKVD IKDFVSTDTA YAVVVQAIND
DGPGPYSNQY TIRTMSRARE GPPVELRVEP DGQRSAVAQW KEPVTSDVPP IGYEIYYVRG
DKSVEEDDSA GLNDWIKISI DDPTKLTHKI QNLLLPDTDY VFKMRAIYPD GPSVFSEPCI
MKTLPDGNAP YIQISTGDNG VEGSTTIQIL PGSQMTIACN ATGIPLPQVK WIKAGNYEID
PSRVDADGNH AQFSLQVANI TEDTTFNCVA QNPLGHANWT INVNLIEGLE PNWRDDFVTS
KSDGGQIVLV FNDELPEYLK PPNEWTIQYT DDAEQPKDQW ESIPSGGAPL TRVEVPNMNP
GTFYYLVVDN PEKGIQTPTL VVMTPKPPSD IRFGKNNDDE QIVDFKPAVA SEPIKEYTIS
VWPSTDPSNV KKFTTPADVT SGVVVDGLEP DTEYNVQVAA EFYEGEELAS EPVTVKTPPR
DVSCECDHGC AFEMNEDAGT MEPKCYCHGG FHLTSDGKSC ERDEEDDATS QAVLQVTPPS
ITTKVAPEEL LTGSSGEVDS TPETLSPVVG PDGKPLVLDK KGKPIDSSGK PVKFDENGDP
IAPEGTKLEK NDNGEWVYPL VDRNGKPLPV DENNKPIITV IDKDGRVVTE TDDGTFVTSD
GKQVEVDDLG RPLDEDGNPY KTNENGQFVI SDVDGAVEGD DEEEQPQVIP LYVVDVDDDG
KYLDEDGNEI PVNEDGDPID VNGKPLEKNE DGKFVKPKES TQETPQPTKI TIVSPDGTPL
PTDASGSPIG LDGQPVPTDA SGKPLAKDGS PLPTDNNGNY VILPSSKNSV DSQPTDDAGR
VIYPVVLPDG SPLATDSTGN FVNRHGDIVE RDDEGKPMGP DGQLLPTDAS GNYIYPVTGP
NDEVLPTDAN GNPIYPVVGP DGTPLPTDAS GAIVGPDGQP IPTDSNGKPL SKEGYPLPVD
NQGNYILLPT EIDAAQSLPT DDAGMPVYPI VKPDGTPLAT DSTGSFINDN GEIIEKDDEG
RPFGPDGLIL PTDASGNYIY PAMGLDGQPL ATDASGNYVL VSTEQTVTKS YPVDDSDITI
HPIVNPDGTP LATDSTGSYV TEDGQIIEKD DEGRPLGPDG QVLPTDDSGN YIYPVAESGE
ETKPTDASGK TVYPVRGPDG TPLPTDASGA VIGPDGEVIP TDENGIPLSQ DGSPLPTDNQ
GNYILVLTSE TPTKTLPIDE SGNVVYPITK PDGTPLATDS TGSFVTEDGT IIAKDDEGKP
LGPDGEVLPT DASGNYVYPV TVSDEQTLPT DDTGKTVYPI RGPDGTPLPT DASGPVIGPD
GEIMPTDENG IPLSKDGTPL PTDNDGNYVI VPSDEETSKE LPIDDSGNVI YPITKPDGTP
LATDSTGSFV TEDGTIIEKD DEGKPLGPDG QILSTDASGN YVYPDPGLDS QILTTDVYGK
PIYTVIGPDG TALPTDASGA AIGPDGTPIS TDETGEPLDK DGSILPTDDY GNFVFVVSQE
LPTDAEVQTP ITKPDGTLLA TDSSGNYVND NGDIIEKDDE GKPLGPDGEV LPTDGTGNFI
YPATTSDGEV IPTDDSGKPL YTIRGPDGTP LPTDETGSAL GPDGEPISTD SSGKPLSKDG
SPLPTDNNGN YVLVPTDEST TKALPTDESG NVVIPITNPD GTSLATDSTG SFVTDDGQII
EKDDEGKPLG PDGAILPTDA SGNYIYPVVG PDGQALPTDE TGKTVYPVRG PDGTPLPTDA
SGAVMGPDGE PIPTDANGKP LSKDGSPLPT DASGNYVLVP SDEVTAKELP TDESGTIVYP
VTRADGTPLA TDSTGSFVTD DGQIIGKDDE GKPLGPDGQV LPTDDSGNYI YPAVGPDGQA
FPTDKSGKPL YPVRGPDGTS LPTDASGAAI GPDGEVIPTD ENGIPLDKDG SPLPTDASGN
YIIVPSGELT MASHPTDDTG NVIYPITKPD GTLLSTDSTG SFVTEDGQII EKDDEGKPLG
PNGEALPTDD LGNYIYPITD SDEQTSPTED VGTSVHLVRG PDGTPLPTDA SGSAIGPDGE
VIPTDENGVP LDKDGSPLPT DNNGNYVLVP TKESVTKILP TDDSEAVVHP ITRQDGTPLS
TDSTGNFVTD NGEIIEKDDE GRPVGPDGQV LSTDVSGNFV YPVTESPNDG EKPIHPVLGP
DGSPLPTDDS GAVIGPDGEV IPTDASGVPL SKLGLPLPTD SDGNYIILSS DTDVTKELPT
DDTGNVIYPI TKPDGTPLGT DTSGSFVSDD GQIIEKDDDG KPLGPDGQVL PTDATGNFIY
PVLGPDGQAL PTDESGKTVY PVRRPDGNPL PTDASGAVIG PGGEPIPTDS SGKPLSADGS
PLPTDASGNY VLVPSDEVTA KELSTDESGT IVYPVTRADG TPLATDSTGS FVTDEGQTIE
KDDEGKPLGP DGQVLPTYAS GNYIYPVIGP DGQALPTDES GKTVYPVRGP DGTPLPTDVS
GAVIGPDGEV IPTDSNGIPL SQDGTPLPTD NQGNYILVPT SETATKALPT DESGNVIYPI
TKADGTPLAT DSTGTFVTDD GQIIEKDDEG KPLGPDGQVL PTDDSGNYIY PVVGPDGQTD
ESGKTVYPVR GSHPTDDTGN VIYPITKPDG TLLATDSTGS FVTEDGQIIE KDDEGKPLGP
DGQVLPTDES GNYVYPEVKS DEQLLPTDHT GKTVYPVHGP DGTPLPTDDS GAIIGPDGEV
IPTDENGIPL SKDGSQLPTD NNGNYVLVPS DEGATKTHPT DETSDAVHPI TKPDGTPLAT
DSTGNFVTEN GDVITKDEEG KPLGPNGQIL PTDASGNYIY PVIGPDGQAL PTDESGKTVY
PVRGPDGTPL PTDASGAVIS PDGEVIPTDA NGIPLDKDGS PLPTDASGNY ILVPSEQDIT
KTLPTDDSGN VIYPITKPDG TSLATDSTGS FVTEGGEIVE RDEDGKPLGP DGQVLPTDAS
GNYIYPVVGP DGQVLPTDDT GKTVYPVYGP DGIPLSTDAS GAVIGPDGEP IPTDASGRPL
DKDGSFLSTD ASGNYILVPS DAPTNEAGPV VVQHQITRPD GTPLATDSSG HFVTEDGVII
ENDKEGRPIG ADGQVLPTDA SNNYIFTDVP TQGYAVFIPT DVVPIELEAP NCDQVDGRVD
TLLFVVESSH TSAPYLDTLK KLIENLLLTT PRDFLPKIGT LIYSATTEIT IDIGSYGDFK
ELFDSTNEIR EIGGIPDVTN ALRTAKMILE ETSRGDTLVL HLLASPMRTS SKVYTERIRA
LPNTRLIHLN EKQWAEDPNA VELLRSHLCI PSEVPLPSMM PTDASGNLLS IPTDEVVTDG
TPTDESGFVI YPITKPDGTP LATDSTGSFV TEDGQIIEKN EDGKPLGPDG QVLPTDNSGN
YIYPIVGPDG QALPTDASGK PIYPVRGPDG TPLPTDASGA VIGPDGEPIP TDASGKPLAQ
DGSPLPVDNE GNYIILPTQQ VDTKEYPTDE TGNVIVPITK PDGTLLPTDS TGSFVTENGD
RIEFNEEGKP LGPDGEVLAT DASGNYVYPG SVVEPTAEPQ EVTHGPDGQV LPTDASGKPI
YPVRGPDGIP LPTDASGAAI GPDGETIATD ENGIPLSKDG SPLPTDNTGN YVLVPSDEGA
TEEKPTQGSE SIVHPITKPD GTPLATDSTG SFVTDDDQVI AKDEDGKPIG PDGQVLPTDS
SGNYIYPVIG PDGQALPTDE SGKTVYPVRG PDGTPLSTDA SGAVIGSDGK PIPTDETGLP
LNKDGSPLPT DNDGNYILIP ADESVVKALP TDEAKEVYPI VQPDGTPLAT DSSGNFVTSS
GDIIDIDDEG KPLGPDGQAL PTDDSGNYIY PVIGPDGQAL PTDESGKTVY PIRGPDGTPL
PTDASGAVIG PDGEPIPTDA SGKPLSQDGS PLPTDASGNY ILVPSDGEVT KTLPTDDVGN
VIYPITKPDG TPLATDSTGS FVTDDGQIIE KDDEGKPLGP DGQVLSTDDS GNYIYPAVGP
NGQTIPTDDT GRTVYPVRGP DGTPLPTDAS GAVIGPDGEP IPTDASGKPL SADGSPLPTD
NNGNYVIVPT DGSTVKSHPT DDSGNTIYPV VNEDGTPLST DLSGNFLTNS GEIVDRDDEG
KPLGPDGQTL PTDASGNYVY LQKVEETTKP LPTDESGNIV YPITKPDGTP LATDSTGSFV
TEDGTVIEKD DEGKPVGPDG QVLPTDESGN YIYPDVTPDG QVQPTDVSGK PVYPVRGPDG
STLPTDASGA ALGPDGKPIP TDSNGVPLSE DGSPLPTDNQ GNYVLVPTSE TVTKSMPTDD
NRNVIYPITM SDGSLLSTDS TGSFVTEDGK VIEKDDEGKP LGPDGQVLPT DASGNYIYPV
HGQDGTPLPT DASGAVIGPD GSPLPTDDSG AVIGPDGEVI PTDSNGIPLN KDGLPLSTDA
SGNYIVVSAE QPGEEIKEIP ITKPDGTLLS TDSTGNFITE NGEIIERDDE GKPIGPDGQI
LPTDASGNYV YPVIGPDGQG LPTDESGKTI YPVRGPDGTP LPTDASGAVI GPDGEPIPTD
ASGKPLSQDG SLLPTDNNGN YVLLPSNEET TQGLTTDESV NVIYPITKPD GTPLATDSTG
NFVTDNGETI EKDEEGKPIG PDGQTLPTDD SGNYIYPVVG PDGQALPTDE SGKTIYPVHG
PDGTPLPTDA SGASIGPDGE PIPTDTSGKP LFKDGSPLPT DSNGNFIIVP SEKRMDEELP
TDDSGKIIYP ITKPDGTPLA SDSTGVFVTE DGTIIEKDDD GKPLGPDGQV LPTDASGNYI
YPIVGPDGKT QPTDESEKTP YPVHGPDGTP LPTDASGAVI GPDGEPIPTD ASGKPLSADG
SPLPTDNNGK YVLVPADEVT TKVLPTDDSG NVVHPITRPD GTPLGTDASG SFITDDGQAI
EKDDEGKPIG PDGQILPIDA SGNYIYPVIG PDGQALPTDE SGKTVYPVRG PDGTPLPTDA
SGAVIGLDGE PIPTDASGKP LSRNGSPLST DSSGNYIFVP TDDEKKDSKK CDISSSLSDI
IFVLVNDGDG AQNYDQFKKA VVGFSRKVDM SPDIIRLAVL SVGSEIAVPL PLGGYQEKEH
LSSILNSFEI PPIVGTEILS PVQAANQQFT SFPRTGISKM VVIFADNEEK STFIGGATYI
TVKYGTTPKD IINTLIEACE KGLVEIVPDD TKHVIDETVP TISSTPVIVD QSGKPLPTDA
SGNYIDNNGK PIVIEGEEPT GPEDQKLSKN KKGEWVYPLV DKFGKPVETD DNDKPVITVV
DNDGNELSKN DDGNWIDLSG NEIDTDELGR PLDSEGNPYK FDDNGHVVIA PQIEEEEETT
PAIPFIIIDG EPINEDDGVY TDKDGNVIPT NSEGKPIDEN GQVLPKNEDG EFVKPKEADT
TQSTIVSPDG SPLPTDASGA AIGPDGEPIP TDSNGRPLAK DGSPLPTDNN GRYVILPSGR
YSGDTETTDE SGNVIYPIIN PDGTPLGTDS TGNYITSIGD IIERDDEGKP IGPDGQVLTT
DASGNYIYPV VGPDGLILPT DATGKPIYPV RGPDGTPLPT DASGAVIGPN GEPIPTDASG
KPLSQDGSPL PTDVNGNYIM LPSDEVTSQS LPTDESGNVI YPITKPDGTP LGTDSSGSFI
TEDGQIIEKD DEGKPIGPDG QILSTDASGN YIYPDVGPDV QTLPTDGDMI SVPTVEATVE
FTSDKTPEVI HSITKPDGTP LSTDSTGEFV TEDGQIIEKD DEGKPIGPDG QVLPTDASGN
YIYPVIGLDG QALPTDKSGK TVYPVRGPNG TPLPTDASGA VIGLDGEPIP TDASGKPLSA
DGSPLPTDAV GNYILVPSDD GVIRTHPTDE SGNTIYPITK PDGTPLATDS TGAFVTDDGQ
VIEKDDEGKP IGPDGQVLPT DASGNYIYPV TSSDGQVLPT DAEKPVIVDQ SGKPLPTDAS
GNYIDNNGKP IVIEGEEPTG PEDQKLSKNK KGEWVYPLVD KFGKPVETDD NDKPVITVVD
NDGNELSKND DGNWIDLSGN EIDTDELGRP LDSEGNPYKF DDNGHVVIAP QIEEEEEATP
AIPFIIIDGE PINEDDGVYT DKDGNVIPTN SEGKPIDENG QVLPKNEYGE FVKPKEADTT
QSTIVSPDGS PLPTDASGAA IGPDGEPIPT DSSGRPISKD GSPLPTDASG NYILVPSGEG
VTDSLPTDEA GNIIYPITKP DGTLLATDST GSFVADDGQI IEKDDEGKPI GPDGQVLPTD
ASGNYIYPVI GPDGQALPTD ESGKTVYPVR GPDGTPLPTD ASGAVIGPDG EPIPTDPSGK
PLSADGSPLP TDINGNYVLV PSDESAAKVL PTDESGSVVY PITKPDGTPL GTDASGSFVT
DDGQAIGKDD EGKPIGPDGQ TLPIDDSGNY IYPVVGPDGQ ALPTDESGKT VYPVLGPDGI
PLPTDASGAV IGPDGEIIPT DASGKPLSAD GSPLPTDNNG NYVLVPADEV TTKVLPTDDS
GNVVHPITRP DGTPLGTDAS GSFVTDDGQA IEKDDEGKPI GPDGQVLPTD ASGNYIYPVI
GPDGQALPTD KSGKTVYPVR GPDGTPLSTD ASGALIGLDG EPIPTDASGK PLSADGSPLP
TDAVGNYILV PSDDGVIRTH PTDESGNTIY PITKPDGTPL ATDSTGAFVT DDGQVIEKDD
EGKPIGPDGQ VLPTDASGNY IYPVTSSDGQ VLPTDAEKPV IVDQSGKPLP TDASGNYIDN
NGKPIVIEGE EPTGPEDQKL SKNEKGEWVY PLVDKFGKPV ETDDNDKPVI TVVDNDGNEL
SKNDDGNWID LSGNEIDTDE LGRPLDSEGN PYKFDDNGHV VIAPQIEEEE ETTPAIPFII
IDGEPINEDD GVYTDKDGNV IPTNSEGKPI DENGQVLPKN EDGEFVKPKE ADTTQSTIVS
PDGSPLPTDA SGAAIGPDGE PIPTDSSGRP ISKDGSPLPT DASGNYILVP SGEGVTDSLP
TDEAGNIIYP ITKPDGTLLA TDSTGSFVAD DGQIIEKDDE GKPIGPDGQV LPTDASGNYI
YPVIGPDGQA LPTDESGKTV YPVRGPDGTP LPTDASGAVI GPDGEPIPTD PSGKPLSADG
SKLPTDINGN YVLVPADEVT TKVLPTDDSG NVVHPITRPD GTPLGTDASG SFITEDGQIV
EKNDDGKPIG PDGQVLPTDS SDNYIYPSIG SDEQAMPTDT TGSVIYPLVS PDGTVIEGPP
KVAKPVGPDG KVLPTDASGH FIGPDGPIPT DYGVTYSDTV TTPDGIPLSN DSTGAFITED
GTVIENNEDG KPIGPDGQVL PTDAYGNYIY PAIGPDGQAL PTDESGNPVY PVRGPDGTPL
PTDVSGAVIG PDGEPIPTDA SGKPLSADGG SPLPTDNNGN YVLVPADEVT TKVLPTDDSG
NVVHPITRPD GTPLGTDASG SFVRDDGQAI EKDDEGKPIG PDGQVLPTDA SGNYIYPVIG
PDGQALPTDE SGKTVYPVRG PDGTPLPTDA SGAVIGLDGE PIPTDASGKP LSAEGSPLPT
DNNGNYVLVP ADEVTTKVLP TDDSGNVVHP ITRPDGTPLG TDASGSFVRD DGQAIEKDDE
GKPIGPDGQV LPTDASGNYI YPVIGPDGQA LPTDESGKTV YPVRGPDGTP LPTDASGAVI
GLDGEPIPTD ASGKPLSAEG SPLPTDNNGN YVLVPAHEVT TKVLPTDDSG NVVHPITRPD
GTPLGTDASG SFVTDDGQAI EKDDEGKPIG PDGQVLPTDA SGNYIYPVTS SDGQVLPTDA
EKPVIVDQSG KPLPTDASGN YIDNNGKPIV IEGEEPTGPE DQKLSKNEKG EWVYPLVDKF
GKPVETDDND KPVITVVDND GNELSKNDDG NWIDLSGNEI DTDELGRPLD SEGNPYKFDD
NGHVVIAPQI EEEEEATPAI PFIIIDGEPI NEDDGVYTDK DGNVIPTNSE GKPIDENGQV
LPKNEDGEFV KPKEADTTQS TIVSPDGSPL PTDASGAAIG PDGEPIPTDS NGRPLAKDGS
PLPTDNNGRY VILPSGRYSG DTETTDESGN VIYPIINPDG TPLGTDSTGN YITSIGDIIE
RDDEGKPIGP DGQVLTTDAS GNYIYPVVGP DGLILPTDAT GKPIYPVRGP DGTPLPTDAS
GAVIGPNGEP IPTDASGKPL SQDGSPLPTD VNGNYIMLPS DEVTSQSLPT DESGNVIYPI
TKPDGTPLGT DSSGSFITED GQIIEKDDEG KPIGPDGQIL STDASGNYIY PDVGPDVQTL
PTDGDMISVP TVEATVEFTS DKTPEVIHSI TKPDGTPLST DSTGEFVTED GQIIEKDDEG
KPIGPDGQVL PTDASGNYIY PVIGLDGQAL PTDKSGKTVY PVRGPNGTPL PTDASGAVIG
LDGEPIPTDA SGKPLSADGS PLPTDAVGNY ILVPSDDGVI RTHPTDESGN TIYPITKPDG
TPLATDSTGA FVTDDGQVIE KDDEGKPIGP DGQVLPTDAS GNYIYPVTSS DGQVLPTDAE
KPVIVDQSGK PLPTDASGNY IDNNGKPIVI EGEEPTGPED QKLSKNKKGE WVYPLVDKFG
KPVETDDNDK PVITVVDNDG NELSKNDDGN WIDLSGNEID TDELGRPLDS EGNPYKFDDN
GHVVIAPQIE EEEEATPAIP FIIIDGEPIN EDDGVYTDKD GNVIPTNSEG KPIDENGQVL
PKNEDGEFVK PKEADTTQST IVSPDGSPLP TDASGAAIGP DGEPIPTDSS GRPISKDGSP
LPTDASGNYI LVPSGEGVTD SLPTDEAGNI IYPITKPDGT LLATDSTGSF VADDGQIIEK
DDEGKPIGPD GQVLPTDASG NYIYPVIGPD GQALPTDESG KTVFPVRGPD GTPLPTDASG
AVIGPDGEPI PTDPSGKPLS ADGSPLPTDI NGNYVLVPSD ESAAKVLPTD ESGSVVYPIT
KPDGTPLGTD SSGSYITEDG QLVGKDEEGK PVGPDGQVLP TDSAGHYVYP ITGADRQILT
TDAAGKPIYS VFNEDGIQLP TDSSGYAIGH DGELVPTEST NGVPLNKDGT PLPTNDSGHF
VLVLPGATVN DSKPTDEVIV SITNPDGTLL GTDSTGAFVT EDGPIIENDD EGKPVGPDGQ
VLPTDDSGNY IYPVIGPDGQ ALPTDESGKT VYPIRGPDGT PLPTDASGAS IGPDGEPIPT
DASGKPLSKD GSPLPTDNDG HYVLVPVDDS TIKAFPTDES GNVAYPITRP DGTPLGTDSS
GSFVTDDGTI IENDDEGKPI GPDGQVLPTD ASGNYIYPVI GPDGQALPTD ESGKTVYPVH
GPDGTPLPTD ASGAAIGPDG EPIPTDASGK PLSQDGSALP TDNNGNFILV PSDKSTTKTL
PTDESGNFIY PITKPDGVLF ATDSTGNYVT DEGELIEKDD NGYPLGPDKR VLPTDGSGNY
IYPAVGSDEK ILPTDNLGKV VYPITRPDGS PLATDSTGVF VTGDGTIVER NEEGKPIGPD
GQVLTTDNSG NYIYPVIGPD GEPLGTDASG KTVYPVRGPD GTPLATDAFG AVIGPDGEPI
PTDASGKPLD QSGFPLPTDN NGNYILVPSD EALGKILPTD ENGNVVYSVT NPDGTPLATD
STGSFIASNG LIVEKDDEGK PIGPDGQVLP TDASGNYIYP VIGPDGQALP TDESGKPIYP
VFTEDGTQLP TDSTGFAIGP DGELVPTDSA NGVPLSKDGS PLPTDASGNY ILPDSGVTTA
NPTDENGYAI YPITKPDGTL LATDSTGSYI TQGGQLIEKD NTGKPIGPDG QVLPTDGSGN
YVYPVVGPDG QALPTDDTGN VVYPVINADG SLLATDSSGS FITENGKIVA KDDEGKPISP
DGQVLPTDAS GNYIYPALGP DGSILPTDSN GKSIYPVRGP DGTPLPTDEF GFAIGPDGKP
IPTDTSGKPL SADGSPLPTD NNGNYILVLS EGVTEHAPTD ENGNVIYPVT NPDGTPLGTD
SSGAFITQDG TVVKKDEDGK PIGPDGQVLP TDNSGNYIYP VIGPDGQVLP TDASGKTVHS
VYGPDGTQLP TDASGSAIGP DGELVPTDVS GRPLSQDGSP LPTDNNGNYA LVVSDEATTK
VLPTDEGGNV IYHITKPDGS LLGTDASGDF ITDHGKAVQK DDEGKPIGPD GSVLPTDTSG
NYIYPITGPD GNVLPTDSNG KPVYPVFNED GTQLPTDSTG SAIDQDGELV STDSTSGVPL
AKDGSPLPTN SAGNYVLVSS GKSQPTDEHG NVIYPITKPD GTLLATDSTG SYLTEDGQLV
EIDDSGKPLG SDGQVLPIDA SGNYIYPALG PDGQALPTDD AGNLVYPIVY PDGTPLATES
TGNYVTENGE VVGKNTDGKP ISPDGQVLPT DASGNYIYPA VGPDGQVLPT DASGKLIYPV
FHPDGTQLPT DASGYAVAPD GSLIPTEFSG KPLGKDGSVL PTDNSGRYVL VHDDREVTQT
IPTDESGNTI YPITRPDGTL LSTDSTGIYL TDEGNVIDRD NEGKPLGPDG QVLPTDGYGN
FVYPADSDIG GAKLLPTDEY GHTLYPVIRP DGSLLSTESS GSFVTDDGTV VSKDSDGKPL
GPAGQVLPTD ASGNYIYPSI GPDGSPLPTD INGKPAYTVI GRYGDVLPTD SLGRAVNIDG
SVVPTDDEGL PIDQYGVVLP TDTTRKLHTL VPTRRPSSFC YVTSHIDLLL VIDSSNNIKV
LDYRVMKELI KNFLTEHFNL RKHQVRVGLV KYGDGAEIPV SLGDYDNEDD LVHRISESRR
LKGRAQLGAG LREALDELSI SGVDGVPQIV LIVKNGKASD DYSSAVKSLK AERNVTVFVV
DAGDDESQQQ NSELTEEDKT IVISQWRGAD SEVLGPIADY ICKIVPNVET SRTWPTPRTK
ATTTSGTGRS CSSIDYESDV IIVLDSSENF TPDEFVSMKD AVASIVDTGF DLAPDVSKIG
FVIYSDKVAV PVALGHYEDK IELLEKITDA EKINDGVAIA LYGLNAARQQ FQLHGRENAT
KVVILITNGK NRGNAAAAAE DLRDMYGVQL FAVAVGSNPE ELATIKRLVG NSNTENVIEV
AQSTEIDDDA AALLKAVCGN TSPKNSEMPA HLTTKRDVLA QKFTTAPMLR TTRAVAGGLC
NDGIRRPYHF NILVDITSRA SADEFRRVLD HLINFFNDRM RDEQHMITIN IITVNSDKVQ
NILSNLRADQ LSEQLNAITQ QSDDTVSPKL GAGIDALAEL SKENYINGAI KLMLIVGSDG
TSSDDALPAA EYANSDFQHN IIAVSVRKPA TDLLSKIAGL PTRVVHLDQW SAPNELFDSW
IAYITCDYAT ASTTRKSTTP KMTTLRPYDR KASKEDATNI ELIPLSPSSL SVSWTCCTNN
KSNYTILYTH DTSITKEKWI RKEVTCRDSF GTHLNELPSD HTYTVCVMTN ERVDNSTALA
IDKNCDSLHI DQNTTAPEDY VKPSPSSCNC QCSEGKAVLR ATCEMVIDTN RPIATLPPAT
VDECPCKVKA HGGRCPKGYI AKDGQCYDID ECETNNGQCS EGCVNTPGSY YCACPHGMMR
DPLDPFNCVN TANSFDKIAA LLANYLEANT KNSGSEVTSE KSDGGRVNYK ATIKSADDKT
ITFEWSHVPE VVRRAFKWLF
