ID   DIH41_AGRIP             Reviewed;         139 AA.
AC   C0HKT4;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Diuretic hormone 41 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Diuretic hormone 41 precursor-related peptide {ECO:0000303|PubMed:29466015};
DE              Short=DH(41)-PP {ECO:0000303|PubMed:29466015};
DE              Short=DH-41-PP {ECO:0000303|PubMed:29466015};
DE   Flags: Precursor;
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 126-139, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- FUNCTION: [Diuretic hormone 41]: Regulation of fluid secretion.
CC       {ECO:0000250|UniProtKB:P82014}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: [Diuretic hormone 41 precursor-related peptide]:
CC       Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe
CC       (AL) and gnathal ganglion (GNG) (at protein level). Expression in CC
CC       and CA detected in all animals, in GNG in most animals, expression in
CC       AL detected in few animals (at protein level).
CC       {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: [Diuretic hormone 41 precursor-related peptide]:
CC       Mass=1651.88; Method=MALDI; Evidence={ECO:0000269|PubMed:29466015};
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKT4; -.
DR   SMR; C0HKT4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..79
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444526"
FT   PEPTIDE         82..122
FT                   /note="Diuretic hormone 41"
FT                   /evidence="ECO:0000250|UniProtKB:P82014"
FT                   /id="PRO_0000444527"
FT   PEPTIDE         126..139
FT                   /note="Diuretic hormone 41 precursor-related peptide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444528"
FT   MOD_RES         122
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P21819"
SQ   SEQUENCE   139 AA;  15427 MW;  C0FA0F83A974D151 CRC64;
     MMWWALWCAV VVAAGSGVAA APAPDSLSPL DMVQMDSSAP DDETLYAMSP MAARYSAGAP
     WLYLLADMPR DSQTGSGRVK RRMPSLSIDQ PMSVLRQKLS QEMERKQQAF RAAVNRNFLN
     DIGKRGFQWT PSVQAVRYI