ID   DIH45_AGRIP             Reviewed;         107 AA.
AC   C0HKT5;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Diuretic hormone 45 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Diuretic hormone 45 precursor-related peptide {ECO:0000303|PubMed:29466015};
DE              Short=DH(45)-PP {ECO:0000303|PubMed:29466015};
DE              Short=DH-45-PP {ECO:0000303|PubMed:29466015};
DE   Flags: Precursor; Fragment;
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 95-107, TISSUE SPECIFICITY,
RP   MASS SPECTROMETRY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- FUNCTION: [Diuretic hormone 45]: Regulation of fluid secretion.
CC       {ECO:0000250|UniProtKB:P67800}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in corpora cardiaca (CC), corpora allata
CC       (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level).
CC       Expression in AL and GNG detected in some animals, in CC and CA in few
CC       animals (at protein level). {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: [Diuretic hormone 45 precursor-related peptide]:
CC       Mass=1498.71; Method=MALDI; Evidence={ECO:0000269|PubMed:29466015};
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DR   AlphaFoldDB; C0HKT5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Neuropeptide; Secreted.
FT   PROPEP          <1..44
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444529"
FT   PEPTIDE         47..91
FT                   /note="Diuretic hormone 45"
FT                   /evidence="ECO:0000305|PubMed:29466015"
FT                   /id="PRO_0000444530"
FT   PEPTIDE         95..107
FT                   /note="Diuretic hormone 45 precursor-related peptide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444531"
FT   MOD_RES         91
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P21819"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   107 AA;  12324 MW;  669EE99667CA96FB CRC64;
     LYAMSPMAAR YSAGAPWLYL LADMPRDSQR LVDPADLHEG RARPKRKMPS LSINNPMEVL
     RQRLILEVAR KQMREANQRQ AVANRLFLQN VGKRGFWANS APTRYDN