ID   DIH45_BOMMO             Reviewed;         147 AA.
AC   B3IUE0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Diuretic hormone 45;
DE   Flags: Precursor;
GN   Name=dh45;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1] {ECO:0000312|EMBL:BAG50375.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tanaka Y., Roller L., Yamanaka N., Kataoka H.;
RT   "Comprehensive analysis of neuropeptide genes in the silkworm, Bombyx
RT   mori.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulation of fluid secretion. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sauvagine/corticotropin-releasing
CC       factor/urotensin I family. {ECO:0000255}.
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DR   EMBL; AB298936; BAG50375.1; -; mRNA.
DR   RefSeq; NP_001124368.1; NM_001130896.1.
DR   RefSeq; XP_012547712.1; XM_012692258.1.
DR   AlphaFoldDB; B3IUE0; -.
DR   STRING; 7091.BGIBMGA007762-TA; -.
DR   GeneID; 100174841; -.
DR   CTD; 100174841; -.
DR   eggNOG; ENOG502SCPI; Eukaryota.
DR   InParanoid; B3IUE0; -.
DR   OrthoDB; 1570517at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0008613; F:diuretic hormone activity; ISS:UniProtKB.
DR   GO; GO:0007589; P:body fluid secretion; ISS:UniProtKB.
DR   InterPro; IPR018446; Corticotropin-releasing_fac_CS.
DR   InterPro; IPR000187; CRF.
DR   Pfam; PF00473; CRF; 1.
DR   SMART; SM00039; CRF; 1.
DR   PROSITE; PS00511; CRF; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..84
FT                   /evidence="ECO:0000250|UniProtKB:P21819"
FT                   /id="PRO_0000365113"
FT   PEPTIDE         87..131
FT                   /note="Diuretic hormone 45"
FT                   /id="PRO_0000365114"
FT   PROPEP          135..147
FT                   /evidence="ECO:0000250|UniProtKB:P21819"
FT                   /id="PRO_0000365115"
FT   MOD_RES         131
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P21819"
SQ   SEQUENCE   147 AA;  16479 MW;  8FD1B28A4AA4D39A CRC64;
     MMWWAVWCAA MVAGSVFTAA APPTDSIDLM QMDPSLADDE SLGFAMQSLS GRYAAAPWLY
     LLADVSHDPQ RMAEFSQSSG RARPKRKMPS LSINNPMEVL RQRLLLEVAR KQMREANQRQ
     AVANRLFLQN VGKRGAWGEP ASYLYNN