ID   DIHR_ACHDO              Reviewed;         441 AA.
AC   Q16983;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Diuretic hormone receptor;
DE            Short=DH-R;
DE   Flags: Precursor;
OS   Acheta domesticus (House cricket).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Ensifera; Gryllidea; Grylloidea;
OC   Gryllidae; Gryllinae; Acheta.
OX   NCBI_TaxID=6997;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Malpighian tubule;
RX   PubMed=8673074; DOI=10.1016/0965-1748(95)00074-7;
RA   Reagan J.D.;
RT   "Molecular cloning and function expression of a diuretic hormone receptor
RT   from the house cricket, Acheta domesticus.";
RL   Insect Biochem. Mol. Biol. 26:1-6(1996).
CC   -!- FUNCTION: Receptor for the insect diurectic hormone. The activity of
CC       this receptor is mediated by G proteins which activate adenylyl
CC       cyclase.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in Malpighian tubules.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000305}.
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DR   EMBL; U15959; AAC47000.1; -; mRNA.
DR   AlphaFoldDB; Q16983; -.
DR   SMR; Q16983; -.
DR   TCDB; 9.A.14.4.4; the g-protein-coupled receptor (gpcr) family.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008036; F:diuretic hormone receptor activity; IEA:InterPro.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR002001; GPCR_2_diuretic_rcpt.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR01127; DIUHORMONER.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF111418; SSF111418; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Signal; Transducer; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..441
FT                   /note="Diuretic hormone receptor"
FT                   /id="PRO_0000012824"
FT   TOPO_DOM        ?..134
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..158
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..224
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..260
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..291
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..315
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        316..338
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..357
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        358..371
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..391
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        392..441
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   441 AA;  49538 MW;  501915AC2E776C5C CRC64;
     MEDAWEADAL EAAEAAAAAA QAVAADAPTT TPSPRTLQRQ RACEALMEGD APDAAPDAPL
     RCAIAWDGVN CWPETPAGAL AVQPCFDELN GIRYDIRQNA TRMCYSNGTW RNYSDYVHCR
     ELVEAESDED AAMAFVFFVG FCLSLVAIAV AIWIFLYFKD LRCLRNTIHT NLMATYICND
     ATWIISAVVQ EYVENGGLCS VLAVLMHYFY LTNFFWMFVE GLYLFLLVVA TFTGEKVKLQ
     IYIIIGWGIP GVIVVTWAII KHLGKTAPDN AGESHPMVLL IKHCPWMAED YFDWIHQAPV
     ITVLAVNLVF LFSIMWVLIT KLQSANTAET QQYRKATKAL LVLFPLLGIT YILMMQGPMD
     GVAGHVFRNA QALLLSLQGF TVALFYCFLN TEVQNTLRHR MSRWRETRTV GGGRRYTLSG
     HSKDWSPRSR TESIRCLQHR S