DIHR_MANSE
ID DIHR_MANSE Reviewed; 395 AA.
AC P35464;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Diuretic hormone receptor;
DE Short=DH-R;
OS Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Sphingidae; Sphinginae; Sphingini; Manduca.
OX NCBI_TaxID=7130;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8276884; DOI=10.1016/s0021-9258(17)42299-x;
RA Reagan J.D.;
RT "Expression cloning of an insect diuretic hormone receptor. A member of the
RT calcitonin/secretin receptor family.";
RL J. Biol. Chem. 269:9-12(1994).
CC -!- FUNCTION: Receptor for the insect diurectic hormone. The activity of
CC this receptor is mediated by G proteins which activate adenylyl
CC cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in Malpighian tubules.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000305}.
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DR EMBL; U03489; AAC46469.1; -; mRNA.
DR AlphaFoldDB; P35464; -.
DR SMR; P35464; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008036; F:diuretic hormone receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 4.10.1240.10; -; 1.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR002001; GPCR_2_diuretic_rcpt.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR01127; DIUHORMONER.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; SSF111418; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..395
FT /note="Diuretic hormone receptor"
FT /id="PRO_0000070330"
FT TOPO_DOM 1..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..111
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..155
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..217
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..272
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..314
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..329
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..349
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 350..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 369..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 395 AA; 45421 MW; 3F8C1A3EFEA01B2D CRC64;
MAEECLARKF NLSDNYCPAY FDGLLCWDPT PWNTLAVQKC FKELYGIQYD DTQNASRLCL
DGVWHNYTNY TNCTERIANG SPTDVASLIY LAGYSLSLAV LSLAVFVFLY FKDLRCLRNT
IHTNLMSTYI LSACSWILNL VLQNWSDESQ QDQTSCMILV ICMNYFYLTN FFWMLVEGLY
LYMLVVETFT AENIKLKVYT TIGWGAPAVF ITIWVISRCF VNVLPSTGPD GLAMFPEAKM
CIWMHEHQVD WIHKAPALVG LALNLFFLIR IMWVLITKLR SANTLETEQY RKATKALLVL
IPLLGITNLL VLCGPSDDSW FAYAFDYTRA LMLSTQGFTV ALFYCFMNTE VRHAIRYHVE
RWKTGRTIGG GRRRGASYSK DWSPRSRTES IRLTV
