ID   DIK1A_DANRE             Reviewed;         428 AA.
AC   Q1RLQ5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Divergent protein kinase domain 1A;
DE   AltName: Full=Protein FAM69A;
GN   Name=dipk1a; Synonyms=fam69a; ORFNames=zgc:136922;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9D6I7}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9D6I7}.
CC   -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC       involved in disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC115333; AAI15334.1; -; mRNA.
DR   RefSeq; NP_001035444.1; NM_001040354.1.
DR   AlphaFoldDB; Q1RLQ5; -.
DR   STRING; 7955.ENSDARP00000086003; -.
DR   PaxDb; Q1RLQ5; -.
DR   Ensembl; ENSDART00000091570; ENSDARP00000086003; ENSDARG00000062955.
DR   GeneID; 678606; -.
DR   KEGG; dre:678606; -.
DR   CTD; 678606; -.
DR   ZFIN; ZDB-GENE-060421-4286; dipk1aa.
DR   eggNOG; ENOG502RPQV; Eukaryota.
DR   GeneTree; ENSGT00390000006452; -.
DR   HOGENOM; CLU_039177_0_0_1; -.
DR   InParanoid; Q1RLQ5; -.
DR   OMA; TMRVLKC; -.
DR   OrthoDB; 661899at2759; -.
DR   PhylomeDB; Q1RLQ5; -.
DR   TreeFam; TF313319; -.
DR   PRO; PR:Q1RLQ5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000062955; Expressed in testis and 20 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   InterPro; IPR029244; FAM69_N.
DR   Pfam; PF12260; PIP49_C; 1.
DR   Pfam; PF14875; PIP49_N; 1.
DR   SMART; SM01299; PIP49_N; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..428
FT                   /note="Divergent protein kinase domain 1A"
FT                   /id="PRO_0000282426"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..428
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  48592 MW;  5637429965D51546 CRC64;
     MARGLFSRAW LSKTHHFQAR LSYIRVKYLF LTWLAVFVSS WVVYVQYSTY TELCRGRECK
     SIICDKYSKG IIDGSACSSL CEESKLYFGR CLSTKPNNQV YTGSWGDQDG VIKCQLSDVL
     HYELGEELEP KKEITLFEKP TRGTSVEKFK EMVASHLKAK VGEQANLSNL VSLILSVADS
     NKDGHISLPE AKSAWALLQL NEVLLAVVLQ GREHTPKLLG FCGDLYVVER VPHAPLFGIT
     LPWPMDLWIP AGMRRSMDQW FTPSWPRKAK IFIGLLELIE DIFHGTFGSF LMCDMRASSF
     GYTDRHDLRL VDGRRVVAEE AFKQAMILQR CKDHEDCVYG ADCRTSCDLS EQRCTAEVAQ
     PNLARACGAM KDYLLRGAPF HLQEELEKQL YACMALKGSA EQMEMEHSLI LNNLKTLLWK
     QISHTTDS