DIK1A_MOUSE
ID DIK1A_MOUSE Reviewed; 428 AA.
AC Q9D6I7; Q3U5P1; Q3V308;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Divergent protein kinase domain 1A {ECO:0000305};
DE AltName: Full=Protein FAM69A;
GN Name=Dipk1a; Synonyms=Fam69a {ECO:0000312|MGI:MGI:1914516};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Bone marrow, Cerebellum, Eye, Hippocampus, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21334309; DOI=10.1016/j.bbrc.2011.02.076;
RA Tennant-Eyles A.J., Moffitt H., Whitehouse C.A., Roberts R.G.;
RT "Characterisation of the FAM69 family of cysteine-rich endoplasmic
RT reticulum proteins.";
RL Biochem. Biophys. Res. Commun. 406:471-477(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:21334309}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:21334309}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:21334309}.
CC -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC involved in disulfide bonds.
CC -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR EMBL; AK013580; BAB28914.1; -; mRNA.
DR EMBL; AK048979; BAC33502.1; -; mRNA.
DR EMBL; AK050305; BAC34177.1; -; mRNA.
DR EMBL; AK053273; BAE43353.1; -; mRNA.
DR EMBL; AK153488; BAE32036.1; -; mRNA.
DR EMBL; BC116683; AAI16684.1; -; mRNA.
DR CCDS; CCDS39200.1; -.
DR RefSeq; NP_080338.1; NM_026062.4.
DR AlphaFoldDB; Q9D6I7; -.
DR SMR; Q9D6I7; -.
DR BioGRID; 212058; 1.
DR IntAct; Q9D6I7; 1.
DR MINT; Q9D6I7; -.
DR STRING; 10090.ENSMUSP00000031198; -.
DR iPTMnet; Q9D6I7; -.
DR PhosphoSitePlus; Q9D6I7; -.
DR SwissPalm; Q9D6I7; -.
DR EPD; Q9D6I7; -.
DR MaxQB; Q9D6I7; -.
DR PaxDb; Q9D6I7; -.
DR PRIDE; Q9D6I7; -.
DR ProteomicsDB; 275580; -.
DR Antibodypedia; 2517; 47 antibodies from 11 providers.
DR Ensembl; ENSMUST00000031198; ENSMUSP00000031198; ENSMUSG00000029270.
DR GeneID; 67266; -.
DR KEGG; mmu:67266; -.
DR UCSC; uc008yni.2; mouse.
DR CTD; 388650; -.
DR MGI; MGI:1914516; Dipk1a.
DR VEuPathDB; HostDB:ENSMUSG00000029270; -.
DR eggNOG; ENOG502QU5P; Eukaryota.
DR GeneTree; ENSGT00390000006452; -.
DR HOGENOM; CLU_039177_0_0_1; -.
DR InParanoid; Q9D6I7; -.
DR OMA; DQSKMKC; -.
DR OrthoDB; 661899at2759; -.
DR PhylomeDB; Q9D6I7; -.
DR TreeFam; TF313319; -.
DR BioGRID-ORCS; 67266; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Dipk1a; mouse.
DR PRO; PR:Q9D6I7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D6I7; protein.
DR Bgee; ENSMUSG00000029270; Expressed in placenta labyrinth and 227 other tissues.
DR ExpressionAtlas; Q9D6I7; baseline and differential.
DR Genevisible; Q9D6I7; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..428
FT /note="Divergent protein kinase domain 1A"
FT /id="PRO_0000282424"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..428
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CONFLICT 41
FT /note="W -> G (in Ref. 1; BAE43353)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="I -> V (in Ref. 1; BAE32036)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="K -> I (in Ref. 1; BAE32036)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 428 AA; 48936 MW; 7111D7C81F082822 CRC64;
MARSLCAGAW LRKPHYLQAR LSYMRVKYLF FSWLVVFVGS WIIYVQYSTY TELCRGKDCK
KIICDKYKTG VIDGPACNSL CVTETLYFGK CLSNKPSNQM YLGVWDNLPG VVKCQMEQAL
HLDFGTELEP RKEIVLFDKP TRGTTVQKFK EMVYSLFKAK LGDQGNLSEL VNLILTVADG
DRDGQVSLGE AKSAWALLQL NEFLLMVILQ DKEHTPKLMG FCGDLYVMES VEYTSLYGIS
LPWVMELFIP SGFRRSMDQL FTPSWPRKAK IAIGLLEFVE DVFHGPYGNF LMCDTSAKNL
GYNEKYDLKM VDMRKIVPET NLKELIKDRH CESDLDCVYG TDCRTSCDLS TMKCTSEVIQ
PNLAKACQLL KDYLLHGAPS EIREELEKQL YSCIALKVTA NQMEMEHSLI LNNLKTLLWK
KISYTNDS
