ID   DIK1A_PONAB             Reviewed;         428 AA.
AC   Q5R634;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Divergent protein kinase domain 1A {ECO:0000305};
DE   AltName: Full=Protein FAM69A;
GN   Name=DIPK1A; Synonyms=FAM69A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9D6I7}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9D6I7}.
CC   -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC       involved in disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR   EMBL; CR860662; CAH92782.1; -; mRNA.
DR   RefSeq; NP_001126623.1; NM_001133151.1.
DR   AlphaFoldDB; Q5R634; -.
DR   STRING; 9601.ENSPPYP00000001334; -.
DR   Ensembl; ENSPPYT00000001379; ENSPPYP00000001334; ENSPPYG00000001151.
DR   GeneID; 100173620; -.
DR   KEGG; pon:100173620; -.
DR   CTD; 388650; -.
DR   eggNOG; ENOG502QU5P; Eukaryota.
DR   GeneTree; ENSGT00390000006452; -.
DR   InParanoid; Q5R634; -.
DR   OrthoDB; 661899at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   InterPro; IPR029244; FAM69_N.
DR   Pfam; PF12260; PIP49_C; 1.
DR   Pfam; PF14875; PIP49_N; 1.
DR   SMART; SM01299; PIP49_N; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..428
FT                   /note="Divergent protein kinase domain 1A"
FT                   /id="PRO_0000282425"
FT   TOPO_DOM        1..27
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..428
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   428 AA;  49024 MW;  1A348DD44643AA4C CRC64;
     MARSLCPGAW LRKPYYLQAR FSYVRMKYLF FSWLVVFVGS WIIYVQYSTY TELCRGKDCK
     KIICDKYKTG VIDGPACNSL CVTETLYFGK CLSTKPNNQM YLGIWDNLPG VVKCQMEQAL
     HLDFGTELEP RKEIVLFDKP TRGTTVQKFK EMVYSLFKAK LGDQGNLSEL VNLILTVADG
     DKDGQVSLGE AKSAWALLQL NEFLLMVILQ DKEHTPKLMG FCGDLYVMES VEYTSLYGIS
     LPWVIELFIP SGFRRSMDQL FTPSWPRKAK IAIGLLEFVE DVFHGPYGNF LMCDTSAKNL
     GYNDKYDLKM VDMRKIVPET NLKELIKDRH CESDLDCVYG TDCRTSCDQS TMKCTSEVIQ
     PNLAKACQLL KDYLLRGAPS EIREELEKQL YSCIALKVTA NQMEMEHSLI LNNLKTLLWK
     KISYTNDS