ID   DIK1A_XENLA             Reviewed;         410 AA.
AC   Q6DCL6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Divergent protein kinase domain 1A {ECO:0000305};
DE   AltName: Full=Protein FAM69A;
GN   Name=dipk1a; Synonyms=fam69a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9D6I7}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9D6I7}.
CC   -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC       involved in disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR   EMBL; BC077992; AAH77992.1; -; mRNA.
DR   RefSeq; NP_001087076.1; NM_001093607.1.
DR   RefSeq; XP_018112294.1; XM_018256805.1.
DR   AlphaFoldDB; Q6DCL6; -.
DR   DNASU; 446911; -.
DR   GeneID; 446911; -.
DR   KEGG; xla:446911; -.
DR   CTD; 446911; -.
DR   Xenbase; XB-GENE-951308; dipk1a.L.
DR   OMA; DQSKMKC; -.
DR   OrthoDB; 661899at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 446911; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   InterPro; IPR029244; FAM69_N.
DR   Pfam; PF12260; PIP49_C; 1.
DR   Pfam; PF14875; PIP49_N; 1.
DR   SMART; SM01299; PIP49_N; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..410
FT                   /note="Divergent protein kinase domain 1A"
FT                   /id="PRO_0000282427"
FT   TOPO_DOM        1..5
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..410
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   410 AA;  46992 MW;  9093D14C5D4BF1CF CRC64;
     MARLSYVRIK YLFFSWLAVF IGSWVIYVRY NSYTELCRGQ ECKTAICDKY RKGIIDGSAC
     EGLCEKETIY FGKCLSAKPN NQIYLGIWGN LEGVIKCQME NTLHLDFGVD LEPRKEIVLF
     DKPTRGTTVQ KFKEMVHSLV KKRLGDQGNL QDLVNLILKA ADSNKDGHVS LPEAKSAWAL
     LQLNEFLLMV ILQDKEHTPK LLGYCGDLYI TERVPYTSLY GISLPWIIEV FIPMGLRKRM
     DQWFTPSWPR KAKIVIGLLE FVEDIFHGLY GNFLMCDVSA KNFGYNDKYD LKMVDMRKII
     PEMSLKEYIK YKSCESDSDC VYGADCGTTC DQSKRCTTDV TQPNLAKVCL LVKDYLLSGT
     PSEIRDELEK QIYSCIALKA ATKHMEMEHA LILNNLKALL WKKISHTNDS