ID   ADC1_RHILO              Reviewed;         247 AA.
AC   Q98AN6; Q8KJA4;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Acetoacetate decarboxylase 1 {ECO:0000255|HAMAP-Rule:MF_00597};
DE            Short=AAD 1 {ECO:0000255|HAMAP-Rule:MF_00597};
DE            Short=ADC 1 {ECO:0000255|HAMAP-Rule:MF_00597};
DE            EC=4.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00597};
GN   Name=adc1 {ECO:0000255|HAMAP-Rule:MF_00597}; OrderedLocusNames=mll5917;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R7A;
RX   PubMed=12003951; DOI=10.1128/jb.184.11.3086-3095.2002;
RA   Sullivan J.T., Trzebiatowski J.R., Cruickshank R.W., Gouzy J., Brown S.D.,
RA   Elliot R.M., Fleetwood D.J., McCallum N.G., Rossbach U., Stuart G.S.,
RA   Weaver J.E., Webby R.J., de Bruijn F.J., Ronson C.W.;
RT   "Comparative sequence analysis of the symbiosis island of Mesorhizobium
RT   loti strain R7A.";
RL   J. Bacteriol. 184:3086-3095(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Catalyzes the conversion of acetoacetate to acetone and
CC       carbon dioxide. {ECO:0000255|HAMAP-Rule:MF_00597}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetoacetate + H(+) = acetone + CO2; Xref=Rhea:RHEA:19729,
CC         ChEBI:CHEBI:13705, ChEBI:CHEBI:15347, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526; EC=4.1.1.4; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00597};
CC   -!- SIMILARITY: Belongs to the ADC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00597}.
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DR   EMBL; AL672114; CAD31314.1; -; Genomic_DNA.
DR   EMBL; BA000012; BAB52286.1; -; Genomic_DNA.
DR   RefSeq; WP_010913619.1; NC_002678.2.
DR   AlphaFoldDB; Q98AN6; -.
DR   SMR; Q98AN6; -.
DR   STRING; 266835.14025686; -.
DR   EnsemblBacteria; BAB52286; BAB52286; BAB52286.
DR   KEGG; mlo:mll5917; -.
DR   PATRIC; fig|266835.9.peg.4710; -.
DR   eggNOG; COG4689; Bacteria.
DR   HOGENOM; CLU_077089_0_0_5; -.
DR   OMA; FEVMRMG; -.
DR   OrthoDB; 978501at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0047602; F:acetoacetate decarboxylase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.400.10; -; 1.
DR   HAMAP; MF_00597; ADC; 1.
DR   InterPro; IPR010451; Acetoacetate_decarboxylase.
DR   InterPro; IPR023653; Acetoacetate_decarboxylase_bac.
DR   InterPro; IPR023375; ADC_dom_sf.
DR   Pfam; PF06314; ADC; 1.
DR   SUPFAM; SSF160104; SSF160104; 1.
PE   3: Inferred from homology;
KW   Decarboxylase; Lyase; Schiff base.
FT   CHAIN           1..247
FT                   /note="Acetoacetate decarboxylase 1"
FT                   /id="PRO_0000207106"
FT   ACT_SITE        116
FT                   /note="Schiff-base intermediate with acetoacetate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00597"
FT   CONFLICT        16
FT                   /note="I -> T (in Ref. 1; CAD31314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        87
FT                   /note="Y -> C (in Ref. 1; CAD31314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        192
FT                   /note="V -> A (in Ref. 1; CAD31314)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        245..246
FT                   /note="AK -> PE (in Ref. 1; CAD31314)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   247 AA;  27390 MW;  C36298F3EA4DCC1C CRC64;
     MHQDTVRGKA FAMPLISPAY PAGPYRFRNR EYLIITYRTD PQKLRDLVPE PLQVCEPMVK
     FEFIRMPDST GFGDYTEGGQ VIPVSFYGRR GSYTHCMFLD DHPPIAGGRE LWGFPKKLAS
     PTLRTETDTL VGTLDYGPVR VATGTMGYKH RAADLASVRA SLAEPNFLLK IIPHVDGTPR
     ICELVEYHLE DVHLRGAWTG PAALNLWSHA LAPVAELPVL EVVSAVHLVA DLTLALGKVV
     HDYLAKA