ID   DIK1B_RAT               Reviewed;         431 AA.
AC   Q5FVL3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Divergent protein kinase domain 1B;
DE   AltName: Full=Pancreatitis-induced protein 49;
DE            Short=PIP49;
DE   AltName: Full=Protein FAM69B;
GN   Name=Dipk1b {ECO:0000312|RGD:1308600}; Synonyms=Fam69b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type II membrane protein {ECO:0000250}.
CC   -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC       involved in disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR   EMBL; AABR03025235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001014200.2; NM_001014178.2.
DR   AlphaFoldDB; Q5FVL3; -.
DR   SMR; Q5FVL3; -.
DR   STRING; 10116.ENSRNOP00000006186; -.
DR   SwissPalm; Q5FVL3; -.
DR   PaxDb; Q5FVL3; -.
DR   Ensembl; ENSRNOT00000006186; ENSRNOP00000006186; ENSRNOG00000004532.
DR   GeneID; 362090; -.
DR   KEGG; rno:362090; -.
DR   UCSC; RGD:1308600; rat.
DR   CTD; 138311; -.
DR   RGD; 1308600; Dipk1b.
DR   eggNOG; ENOG502QU5P; Eukaryota.
DR   GeneTree; ENSGT00390000006452; -.
DR   HOGENOM; CLU_039177_0_0_1; -.
DR   InParanoid; Q5FVL3; -.
DR   OMA; WALLHIN; -.
DR   OrthoDB; 661899at2759; -.
DR   PhylomeDB; Q5FVL3; -.
DR   TreeFam; TF313319; -.
DR   PRO; PR:Q5FVL3; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000004532; Expressed in frontal cortex and 20 other tissues.
DR   Genevisible; Q5FVL3; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   InterPro; IPR029244; FAM69_N.
DR   Pfam; PF12260; PIP49_C; 1.
DR   Pfam; PF14875; PIP49_N; 1.
DR   SMART; SM01299; PIP49_N; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..431
FT                   /note="Divergent protein kinase domain 1B"
FT                   /id="PRO_0000287233"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..431
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           5..6
FT                   /note="May mediate ER retention"
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..94
FT                   /evidence="ECO:0000305"
FT   DISULFID        62..117
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   431 AA;  48838 MW;  9068CAD8E62DBF8D CRC64;
     MRRLRRLVHL VLLCPFSKGL QGRLPGLRVK YVLLVWLGIF VGSWMVYVHY SSYSELCRGH
     VCQVVICDQY QKGIISGSVC QDLCELQKVE WRTCLSSAPG QQVYSGLWQD KEVTIKCGIE
     EALNSKAWPD AVPRRELVLF DKPTRGTSIK EFREMTLSFL KANLGDLPSL PALVDQILLM
     ADFNKDSRVS LAEAKSVWAL LQRNEFLLLL SLQEKEHASR LLGYCGDLYL TESIPHGSWH
     GAVLLPALRP LLPSVLHRAL QQWFGPAWPW RAKIAIGLLE FVEELFHGSY GTFYMCETTL
     ANVGYTATYD FKMADLQQVA PEATVRRFLQ GRHCEQSSDC IYGRDCRAPC DKLMRQCKGD
     LIQPNLAKVC ELLRDYLLPG APADLYEELG KQLRTCTTLS GLASQVEAHH SLVLSHLKTL
     LWREISNTNY S