ID   DIK1B_XENTR             Reviewed;         431 AA.
AC   A0JPE1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Divergent protein kinase domain 1B {ECO:0000305};
DE   AltName: Full=Protein FAM69B;
GN   Name=dipk1b; Synonyms=fam69b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type II membrane protein {ECO:0000250}.
CC   -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC       involved in disulfide bonds. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR   EMBL; BC127379; AAI27380.1; -; mRNA.
DR   RefSeq; NP_001090694.1; NM_001097225.1.
DR   AlphaFoldDB; A0JPE1; -.
DR   SMR; A0JPE1; -.
DR   STRING; 8364.ENSXETP00000048300; -.
DR   DNASU; 100036673; -.
DR   GeneID; 100036673; -.
DR   KEGG; xtr:100036673; -.
DR   CTD; 138311; -.
DR   Xenbase; XB-GENE-960964; dipk1b.
DR   eggNOG; ENOG502QU5P; Eukaryota.
DR   InParanoid; A0JPE1; -.
DR   OrthoDB; 661899at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   InterPro; IPR029244; FAM69_N.
DR   Pfam; PF12260; PIP49_C; 1.
DR   Pfam; PF14875; PIP49_N; 1.
DR   SMART; SM01299; PIP49_N; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..431
FT                   /note="Divergent protein kinase domain 1B"
FT                   /id="PRO_0000287234"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..431
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           5..6
FT                   /note="May mediate ER retention"
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..94
FT                   /evidence="ECO:0000305"
FT   DISULFID        62..117
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   431 AA;  49052 MW;  F3DF8D8BF56F330B CRC64;
     MRKLRRLVHM VLFCPISKGL QSRLPGIKVK YLFLAWLSVF VGSWVVYMHY SSYSELCRGH
     VCRMIICDQY KKGIISGSAC KDLCDERTLV FQQCLSSSPT QQVYSGRWRD REVIIKCGVE
     ETLKADSNPD SPPRRELVLF DKPTRGTSMD EFKEMLGNFL KANLGEQVSL TALVSQILTM
     ADVNNDGKVS LAEAKSIWAL LHLNEILLML SLREKEHTSQ LLGHCGDLYV TEKIPHDSLY
     GSQIPGFLQT LLPSPVHRLV HQWCAPAWPR RAKIAIGLLE FVEEIFHGTY GSFFICDSSF
     KNIGYNEKYD FKVVDLRKVA TEMTIRGFLK GRHCEQNSDC TFGSDCTAAC DKLMKQCRND
     VIQPNLAKAC QLLQDYLLYG SPSDLREELQ KQLRTCMTLS GLASQMEVHH SLILNNLKTL
     LWKKISNTKY S