DIK1C_HUMAN
ID DIK1C_HUMAN Reviewed; 419 AA.
AC Q0P6D2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Divergent protein kinase domain 1C {ECO:0000305};
DE AltName: Full=Protein FAM69C;
GN Name=DIPK1C {ECO:0000312|HGNC:HGNC:31729}; Synonyms=C18orf51, FAM69C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8BQT2}; Single-pass type II membrane protein
CC {ECO:0000250|UniProtKB:Q8BQT2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0P6D2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0P6D2-2; Sequence=VSP_025146;
CC -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC involved in disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR EMBL; AC009704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019628; AAH19628.1; -; mRNA.
DR CCDS; CCDS42445.2; -. [Q0P6D2-1]
DR RefSeq; NP_001037834.2; NM_001044369.2. [Q0P6D2-1]
DR AlphaFoldDB; Q0P6D2; -.
DR BioGRID; 125930; 1.
DR IntAct; Q0P6D2; 1.
DR STRING; 9606.ENSP00000344331; -.
DR iPTMnet; Q0P6D2; -.
DR PhosphoSitePlus; Q0P6D2; -.
DR BioMuta; FAM69C; -.
DR DMDM; 296439351; -.
DR MassIVE; Q0P6D2; -.
DR PaxDb; Q0P6D2; -.
DR PeptideAtlas; Q0P6D2; -.
DR PRIDE; Q0P6D2; -.
DR ProteomicsDB; 58776; -. [Q0P6D2-1]
DR ProteomicsDB; 58777; -. [Q0P6D2-2]
DR Antibodypedia; 62764; 5 antibodies from 5 providers.
DR DNASU; 125704; -.
DR Ensembl; ENST00000343998.8; ENSP00000344331.6; ENSG00000187773.9. [Q0P6D2-1]
DR Ensembl; ENST00000400291.2; ENSP00000383148.2; ENSG00000187773.9. [Q0P6D2-2]
DR GeneID; 125704; -.
DR KEGG; hsa:125704; -.
DR MANE-Select; ENST00000343998.8; ENSP00000344331.6; NM_001044369.3; NP_001037834.2.
DR UCSC; uc002llk.4; human. [Q0P6D2-1]
DR CTD; 125704; -.
DR GeneCards; DIPK1C; -.
DR HGNC; HGNC:31729; DIPK1C.
DR HPA; ENSG00000187773; Tissue enhanced (brain, choroid plexus, retina).
DR MIM; 614544; gene.
DR neXtProt; NX_Q0P6D2; -.
DR OpenTargets; ENSG00000187773; -.
DR PharmGKB; PA165428999; -.
DR VEuPathDB; HostDB:ENSG00000187773; -.
DR eggNOG; ENOG502QSPC; Eukaryota.
DR GeneTree; ENSGT00390000006452; -.
DR HOGENOM; CLU_042490_0_0_1; -.
DR InParanoid; Q0P6D2; -.
DR OMA; LHYDRGK; -.
DR OrthoDB; 1035909at2759; -.
DR PhylomeDB; Q0P6D2; -.
DR TreeFam; TF313319; -.
DR PathwayCommons; Q0P6D2; -.
DR SignaLink; Q0P6D2; -.
DR BioGRID-ORCS; 125704; 8 hits in 1067 CRISPR screens.
DR ChiTaRS; DIPK1C; human.
DR GenomeRNAi; 125704; -.
DR Pharos; Q0P6D2; Tdark.
DR PRO; PR:Q0P6D2; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q0P6D2; protein.
DR Bgee; ENSG00000187773; Expressed in ventricular zone and 110 other tissues.
DR Genevisible; Q0P6D2; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Endoplasmic reticulum; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..419
FT /note="Divergent protein kinase domain 1C"
FT /id="PRO_0000286707"
FT TOPO_DOM 1..22
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..419
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT MOTIF 16..17
FT /note="May mediate ER retention"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..299
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025146"
SQ SEQUENCE 419 AA; 46420 MW; 320959B6D70EA7DF CRC64;
MARAAGARGP AGWCRRRGRC GRGTLLAFAA WTAGWVLAAA LLLRAHPGVL SERCTDEKSR
RILAALCQDY QGGTLAGDLC EDLCVAGELL FQRCLHYNRG KKVLQADWRG RPVVLKSKEE
AFSSFPPLSL LEEEAGEGGQ DMPEAELLLM VAGEVKSALG LELSNSSLGP WWPGRRGPRW
RGQLASLWAL LQQEEYVYFS LLQDLSPHVL PVLGSCGHFY AVEFLAAGSP HHRALFPLDR
APGAPGGGQA KAISDIALSF LDMVNHFDSD FSHRLHLCDI KPENFAIRSD FTVVAIDVDM
AFFEPKMREI LEQNCTGDED CNFFDCFSRC DLRVNKCGAQ RVNNNLQVIC DKIFRHWFSA
PLKSSAVSFQ LQLQLQEAVQ ECADPGVPSG NTRRAASSVF WKLRQLLQAT LRELQEAEK
