DIK1C_MOUSE
ID DIK1C_MOUSE Reviewed; 410 AA.
AC Q8BQT2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Divergent protein kinase domain 1C;
DE AltName: Full=Protein FAM69C;
GN Name=Dipk1c; Synonyms=Fam69c {ECO:0000312|MGI:MGI:3041188};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 115-410 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21334309; DOI=10.1016/j.bbrc.2011.02.076;
RA Tennant-Eyles A.J., Moffitt H., Whitehouse C.A., Roberts R.G.;
RT "Characterisation of the FAM69 family of cysteine-rich endoplasmic
RT reticulum proteins.";
RL Biochem. Biophys. Res. Commun. 406:471-477(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:21334309}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:21334309}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BQT2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BQT2-2; Sequence=VSP_039089;
CC -!- TISSUE SPECIFICITY: Mainly expressed in the brain and eye, some
CC expression in kidney and skeletal muscle.
CC {ECO:0000269|PubMed:21334309}.
CC -!- PTM: Among the many cysteines in the lumenal domain, most are probably
CC involved in disulfide bonds.
CC -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI19041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI19043.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK046504; BAC32758.1; -; mRNA.
DR EMBL; AC142448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119040; AAI19041.1; ALT_INIT; mRNA.
DR EMBL; BC119042; AAI19043.1; ALT_INIT; mRNA.
DR CCDS; CCDS29384.1; -. [Q8BQT2-2]
DR RefSeq; NP_776131.1; NM_173770.4. [Q8BQT2-2]
DR RefSeq; XP_006526534.1; XM_006526471.3.
DR RefSeq; XP_006526538.1; XM_006526475.2. [Q8BQT2-2]
DR RefSeq; XP_017173394.1; XM_017317905.1. [Q8BQT2-2]
DR RefSeq; XP_017173395.1; XM_017317906.1. [Q8BQT2-2]
DR AlphaFoldDB; Q8BQT2; -.
DR STRING; 10090.ENSMUSP00000057697; -.
DR PhosphoSitePlus; Q8BQT2; -.
DR PaxDb; Q8BQT2; -.
DR PRIDE; Q8BQT2; -.
DR ProteomicsDB; 266828; -. [Q8BQT2-1]
DR ProteomicsDB; 266829; -. [Q8BQT2-2]
DR Antibodypedia; 62764; 5 antibodies from 5 providers.
DR DNASU; 240479; -.
DR Ensembl; ENSMUST00000052501; ENSMUSP00000057697; ENSMUSG00000047992. [Q8BQT2-2]
DR Ensembl; ENSMUST00000161429; ENSMUSP00000124603; ENSMUSG00000047992. [Q8BQT2-1]
DR Ensembl; ENSMUST00000235504; ENSMUSP00000158524; ENSMUSG00000047992. [Q8BQT2-2]
DR GeneID; 240479; -.
DR KEGG; mmu:240479; -.
DR UCSC; uc008fuv.1; mouse. [Q8BQT2-1]
DR CTD; 125704; -.
DR MGI; MGI:3041188; Dipk1c.
DR VEuPathDB; HostDB:ENSMUSG00000047992; -.
DR eggNOG; ENOG502QSPC; Eukaryota.
DR GeneTree; ENSGT00390000006452; -.
DR HOGENOM; CLU_042490_1_0_1; -.
DR InParanoid; Q8BQT2; -.
DR OMA; LHYDRGK; -.
DR OrthoDB; 1035909at2759; -.
DR PhylomeDB; Q8BQT2; -.
DR TreeFam; TF313319; -.
DR BioGRID-ORCS; 240479; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Fam69c; mouse.
DR PRO; PR:Q8BQT2; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BQT2; protein.
DR Bgee; ENSMUSG00000047992; Expressed in ventricular zone and 43 other tissues.
DR ExpressionAtlas; Q8BQT2; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Endoplasmic reticulum; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..410
FT /note="Divergent protein kinase domain 1C"
FT /id="PRO_0000286708"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..410
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT MOTIF 18..19
FT /note="May mediate ER retention"
FT VAR_SEQ 1..146
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_039089"
SQ SEQUENCE 410 AA; 45976 MW; 306CBDAFDF165D44 CRC64;
MARAAGERGR AARCGRWRRG ALLAFAAWTA GWVLAAALLL RAHPSVLSER CTDEKSRRIL
AALCQDYRRG WLTGALCEDL CVGGELLYQR CLYYERGKKV LQAQWRGRTV VLKSKREAFS
SFPPLTLLEE EAGAGAPGIP EAELLLMVAG EVKNTLGLEL PNNSIAPLWP ARQGPGWRQQ
LASAWSLLQQ EEYVYFSLLP DLSRHILPVL GSCGHFYAVE YLAAGSPHHK ALFPLDDAGQ
AQAISHIALS FLDMVSHFDS DFSHRLHLCD VKPENFAIKR DFTVVAIDVD MAFFEPKMRE
ILEQNCTGDE DCNFFDCFSK CDLRVHKCGA QRVNSNLQVI CDKIFRHWFS STHRSPAVSL
QLRLQLQQAV QECAQHGGSS GNSWTASSSV FWKLRWLLQA TLKELQEAEK
