ID   DIK2A_XENTR             Reviewed;         429 AA.
AC   B1H2T2;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Divergent protein kinase domain 2A {ECO:0000305};
DE   AltName: Full=Deleted in autism protein 1 homolog;
DE   Flags: Precursor;
GN   Name=dipk2a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in cardiomyocyte proliferation through
CC       paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling
CC       cascade. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle
CC       {ECO:0000250}. Golgi apparatus {ECO:0000250}. Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR   EMBL; BC161119; AAI61119.1; -; mRNA.
DR   RefSeq; NP_001120404.1; NM_001126932.1.
DR   AlphaFoldDB; B1H2T2; -.
DR   PaxDb; B1H2T2; -.
DR   Ensembl; ENSXETT00000003422; ENSXETP00000003422; ENSXETG00000001626.
DR   GeneID; 100145480; -.
DR   KEGG; xtr:100145480; -.
DR   CTD; 205428; -.
DR   Xenbase; XB-GENE-945791; dipk2a.
DR   eggNOG; ENOG502QUEB; Eukaryota.
DR   HOGENOM; CLU_052524_0_0_1; -.
DR   InParanoid; B1H2T2; -.
DR   OMA; TKICRRA; -.
DR   OrthoDB; 1199714at2759; -.
DR   PhylomeDB; B1H2T2; -.
DR   TreeFam; TF313319; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001626; Expressed in 4-cell stage embryo and 12 other tissues.
DR   ExpressionAtlas; B1H2T2; baseline.
DR   GO; GO:0030126; C:COPI vesicle coat; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0060038; P:cardiac muscle cell proliferation; ISS:UniProtKB.
DR   GO; GO:0014066; P:regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
DR   InterPro; IPR020519; DIPK2A/B.
DR   InterPro; IPR022049; FAM69_kinase_dom.
DR   PANTHER; PTHR32073; PTHR32073; 1.
DR   Pfam; PF12260; PIP49_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Golgi apparatus; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..429
FT                   /note="Divergent protein kinase domain 2A"
FT                   /id="PRO_0000353113"
SQ   SEQUENCE   429 AA;  49413 MW;  4B49E16FEB99138A CRC64;
     MLRLASLKFG RLFRYAKVLF AASLLVVMLL NTHSLLSSFQ RNELTDRRFL SLNKCPACFG
     TSWCRKFMNG QLSFEGWGRL RLLDFFNVKN VHFAQYGEPR EGSRRVVLKR LGSNHELSEL
     DQRICKKATG RPRCDLVQAM YKTDFARLNG DVRLLTPDVV EGWSDLVHCP SQRLLDRLVR
     RYAETKDSGS FLLRNLKDTE RMQLLLTLAF NPEPLVLQSF PSDEGWPFAK YLGACGRMVA
     VNYVGEELWS YFNAPWEKRV DLAWQLMEIA EQLTNNDFDF ALYLLDVSFD NFAVGPRDGK
     VIIVDAENVL VADKKLIKQN KPENWDVWYE SKFDDCDKEA CLSFSKEILC SRATVDHNYY
     AICQNLLSRH ATWRGTSGGL LHDPPAEIAK DGRLEALLDE CANPKKRYGR FKSAKELREY
     LAQLSNNAR