DIK2B_MOUSE
ID DIK2B_MOUSE Reviewed; 435 AA.
AC Q8C3I9;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Divergent protein kinase domain 2B {ECO:0000305};
DE AltName: Full=Deleted in autism-related protein 1 homolog;
DE Flags: Precursor;
GN Name=Dipk2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the DIPK family. {ECO:0000305}.
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DR EMBL; AK085770; BAC39535.1; -; mRNA.
DR EMBL; AL732451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX004855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466584; EDL35730.1; -; Genomic_DNA.
DR EMBL; BC118515; AAI18516.1; -; mRNA.
DR CCDS; CCDS30038.1; -.
DR RefSeq; NP_780437.1; NM_175228.4.
DR AlphaFoldDB; Q8C3I9; -.
DR STRING; 10090.ENSMUSP00000046567; -.
DR GlyGen; Q8C3I9; 2 sites.
DR PaxDb; Q8C3I9; -.
DR PRIDE; Q8C3I9; -.
DR Antibodypedia; 455; 117 antibodies from 16 providers.
DR DNASU; 75905; -.
DR Ensembl; ENSMUST00000044188; ENSMUSP00000046567; ENSMUSG00000037358.
DR GeneID; 75905; -.
DR KEGG; mmu:75905; -.
DR UCSC; uc009ssp.1; mouse.
DR CTD; 79742; -.
DR MGI; MGI:1923155; Dipk2b.
DR VEuPathDB; HostDB:ENSMUSG00000037358; -.
DR eggNOG; ENOG502QRQX; Eukaryota.
DR GeneTree; ENSGT00520000055625; -.
DR HOGENOM; CLU_051861_0_0_1; -.
DR InParanoid; Q8C3I9; -.
DR OMA; PHVKPSY; -.
DR OrthoDB; 1199714at2759; -.
DR PhylomeDB; Q8C3I9; -.
DR TreeFam; TF353643; -.
DR BioGRID-ORCS; 75905; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Dipk2b; mouse.
DR PRO; PR:Q8C3I9; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8C3I9; protein.
DR Bgee; ENSMUSG00000037358; Expressed in hindlimb stylopod muscle and 29 other tissues.
DR Genevisible; Q8C3I9; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR020519; DIPK2A/B.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR PANTHER; PTHR32073; PTHR32073; 1.
DR Pfam; PF12260; PIP49_C; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..435
FT /note="Divergent protein kinase domain 2B"
FT /id="PRO_0000353115"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 395
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 435 AA; 49042 MW; 0A1B466BB04CEB1D CRC64;
MESQWRGAAA TAFHQHWLAR LLLWVSTLSC SFSLPASLPP SLVPRVRSSY TMGKTFLGLD
KCNACIGTSI CKKFFKEEIR FDNSLASHLG LPPQDLHSYA ANYSDDSKTW RPVEISQLVS
RYQIEISDRR ICASVSAPKT CSIERILQKT GRFQKWLQAK RLTPDLVQGL PSPFLRCPSQ
RLLDRVVRRY AEVVDAGSIF MDHFTAGDKL RLLYTLAVNA HPIILQIFPG AEGWPMPRYL
GSCGRFLVST STRPLQEFYD ASPEQAADLA YQLLRVLESL RSNDLNYFFY FTHVDAGMFG
IFDNGHLFIR DASALGIIDK QEGSQAAART GENEDIFSCL VSDCQIQLSS CDTVPEKQSL
VLVCQQLLPQ LLQGKFPSPV QKEIDSALSL CSKDNSTDLE VLGATSWLKD ILRSLRTCDP
RFAYRYPDCK YNDRF
