ID   DIL1_SCHPO              Reviewed;         360 AA.
AC   Q9P3W4;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Dynein intermediate light chain dil1;
GN   Name=dil1; ORFNames=SPAC458.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   REVISION OF GENE MODEL, ACETYLATION, IDENTIFICATION BY MASS SPECTROMETRY,
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH RGA3; SEC10; SEC16;
RP   SYP1; RVB2; SPBC19C7.04C; SPBC2F12.05C AND SPAC3A11.10C.
RX   PubMed=20404563; DOI=10.4161/cc.9.9.11526;
RA   Rumpf C., Cipak L., Novatchkova M., Li Z., Polakova S., Dudas A.,
RA   Kovacikova I., Miadokova E., Ammerer G., Gregan J.;
RT   "High-throughput knockout screen in Schizosaccharomyces pombe identifies a
RT   novel gene required for efficient homolog disjunction during meiosis I.";
RL   Cell Cycle 9:1802-1808(2010).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the cytoplasmic dynein which acts as a motor for
CC       the intracellular retrograde motility of vesicles and organelles along
CC       microtubules (By similarity). Promotes oscillatory nuclear movement and
CC       efficient pairing of homologous centromeres during meiotic prophase.
CC       {ECO:0000250, ECO:0000269|PubMed:20404563}.
CC   -!- SUBUNIT: The dynein complex consists of at least two heavy chains and a
CC       number of intermediate and light chains (By similarity). Interacts with
CC       rga3, sec10, sec16, syp1, rvb2, spbc19c7.04c, spbc2f12.05 and
CC       spac3a11.10c. {ECO:0000250, ECO:0000269|PubMed:20404563}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:20404563}.
CC       Note=Localized to the leading edge of the horsetail nucleus, where the
CC       spindle pole body (SPB) is expected, and to the leading microtubules.
CC       In cycling cells, forms foci which distributed asymmetrically during
CC       cell division.
CC   -!- PTM: The N-terminal part is acetylated. {ECO:0000269|PubMed:20404563}.
CC   -!- SIMILARITY: Belongs to the dynein light intermediate chain DYN3 family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAB93846.2; -; Genomic_DNA.
DR   RefSeq; NP_594698.2; NM_001020126.2.
DR   AlphaFoldDB; Q9P3W4; -.
DR   BioGRID; 280001; 19.
DR   STRING; 4896.SPAC458.04c.1; -.
DR   PaxDb; Q9P3W4; -.
DR   PRIDE; Q9P3W4; -.
DR   EnsemblFungi; SPAC458.04c.1; SPAC458.04c.1:pep; SPAC458.04c.
DR   GeneID; 2543586; -.
DR   KEGG; spo:SPAC458.04c; -.
DR   PomBase; SPAC458.04c; -.
DR   VEuPathDB; FungiDB:SPAC458.04c; -.
DR   HOGENOM; CLU_674658_0_0_1; -.
DR   OMA; NHESNNA; -.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   Reactome; R-SPO-9646399; Aggrephagy.
DR   PRO; PR:Q9P3W4; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005938; C:cell cortex; IDA:PomBase.
DR   GO; GO:0030981; C:cortical microtubule cytoskeleton; IDA:PomBase.
DR   GO; GO:1903754; C:cortical microtubule plus-end; IDA:PomBase.
DR   GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR   GO; GO:0005868; C:cytoplasmic dynein complex; IDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IDA:PomBase.
DR   GO; GO:0110092; C:nucleus leading edge; IDA:PomBase.
DR   GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR   GO; GO:0030989; P:dynein-driven meiotic oscillatory nuclear movement; IMP:PomBase.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   InterPro; IPR008467; Dynein1_light_intermed_chain.
DR   PANTHER; PTHR12688; PTHR12688; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cell cycle; Cytoplasm; Cytoskeleton; Dynein; Meiosis;
KW   Microtubule; Motor protein; Reference proteome.
FT   CHAIN           1..360
FT                   /note="Dynein intermediate light chain dil1"
FT                   /id="PRO_0000116845"
SQ   SEQUENCE   360 AA;  41078 MW;  06A951CBB4CF2342 CRC64;
     MDELLEKLLN DLKKKEPKAC SIICIGEDLD IIQCMNEHGC FSGGSYSELS NDCETVNFRG
     IAYKCFFTKD QVKVNFWQIS HLTGGLFNFL VSQALNEHGL DLLWIIMVVA QTLSALVSFP
     EKLLNILRNM KTILINTEET VRNRFEESQN KKLVALLDKN STTLDISSGI LLNFTVVLKQ
     LKHALGLHTS VDNSQEFILQ FLRTTLLSVP TSSIVSISAD PTSWNNLNVL MKYNFMFQKF
     KPRDFHAQTI QSETMFIPPC WDTISKIQSV NHEFNIALFK QTAKNFYDTL DISLLLGLFD
     KSISMLNCHS SKISDGDIPY KSHQVFLQEL QNKYSEIKTY SSNKLNKSSI KSSLWKDLIQ