ID   DIM6_STRCO              Reviewed;         177 AA.
AC   Q02058;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Actinorhodin polyketide dimerase;
DE            EC=1.-.-.-;
DE   AltName: Full=actI ORF6;
GN   Name=actVB; OrderedLocusNames=SCO5092; ORFNames=SCBAC28G1.18;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=1527048; DOI=10.1016/s0021-9258(18)41772-3;
RA   Fernandez-Moreno M.A., Martinez E., Boto L., Hopwood D.A., Malpartida F.;
RT   "Nucleotide sequence and deduced functions of a set of cotranscribed genes
RT   of Streptomyces coelicolor A3(2) including the polyketide synthase for the
RT   antibiotic actinorhodin.";
RL   J. Biol. Chem. 267:19278-19290(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- PATHWAY: Antibiotic biosynthesis; actinorhodin biosynthesis.
CC   -!- SIMILARITY: To S.pristinaespiralis SnaC. {ECO:0000305}.
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DR   EMBL; X63449; CAA45048.1; -; Genomic_DNA.
DR   EMBL; AL939122; CAC44205.1; -; Genomic_DNA.
DR   PIR; S25845; S25845.
DR   RefSeq; NP_629242.1; NC_003888.3.
DR   RefSeq; WP_003973886.1; NZ_VNID01000008.1.
DR   AlphaFoldDB; Q02058; -.
DR   SMR; Q02058; -.
DR   STRING; 100226.SCO5092; -.
DR   GeneID; 1100533; -.
DR   KEGG; sco:SCO5092; -.
DR   PATRIC; fig|100226.15.peg.5172; -.
DR   eggNOG; COG1853; Bacteria.
DR   HOGENOM; CLU_059021_1_4_11; -.
DR   InParanoid; Q02058; -.
DR   OMA; LLWSERN; -.
DR   PhylomeDB; Q02058; -.
DR   UniPathway; UPA00173; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0042602; F:riboflavin reductase (NADPH) activity; IBA:GO_Central.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006208; P:pyrimidine nucleobase catabolic process; IBA:GO_Central.
DR   Gene3D; 2.30.110.10; -; 1.
DR   InterPro; IPR002563; Flavin_Rdtase-like_dom.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   Pfam; PF01613; Flavin_Reduct; 1.
DR   SMART; SM00903; Flavin_Reduct; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Oxidoreductase; Reference proteome.
FT   CHAIN           1..177
FT                   /note="Actinorhodin polyketide dimerase"
FT                   /id="PRO_0000079899"
SQ   SEQUENCE   177 AA;  18393 MW;  D3749EF33F2BB3C6 CRC64;
     MAADQGMLRD AMARVPAGVA LVTAHDRGGV PHGFTASSFV SVSMEPPLAL VCLARTANSF
     PVFDSCGEFA VSVLREDHTD LAMRFARKSA DKFAGGEFVR TARGATVLDG AVAVVECTVH
     ERYPAGDHII LLGEVQSVHV EEKGVPAVYV DRRFAALCSA AGACPSATGR GVPAHAG