DIML_CAEEL
ID DIML_CAEEL Reviewed; 525 AA.
AC O17397;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Diminuto-like protein;
GN ORFNames=F52H2.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the DIMINUTO family. {ECO:0000305}.
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DR EMBL; FO081446; CCD71661.1; -; Genomic_DNA.
DR PIR; T32481; T32481.
DR RefSeq; NP_508463.1; NM_076062.3.
DR AlphaFoldDB; O17397; -.
DR STRING; 6239.F52H2.6; -.
DR EPD; O17397; -.
DR PaxDb; O17397; -.
DR PeptideAtlas; O17397; -.
DR EnsemblMetazoa; F52H2.6a.1; F52H2.6a.1; WBGene00018718.
DR GeneID; 186134; -.
DR UCSC; F52H2.6; c. elegans.
DR CTD; 186134; -.
DR WormBase; F52H2.6; CE10874; WBGene00018718; -.
DR eggNOG; KOG1262; Eukaryota.
DR GeneTree; ENSGT00390000008338; -.
DR HOGENOM; CLU_025883_4_0_1; -.
DR InParanoid; O17397; -.
DR OMA; YIPSRHY; -.
DR OrthoDB; 733611at2759; -.
DR PhylomeDB; O17397; -.
DR Reactome; R-CEL-191273; Cholesterol biosynthesis.
DR Reactome; R-CEL-6807047; Cholesterol biosynthesis via desmosterol.
DR Reactome; R-CEL-6807062; Cholesterol biosynthesis via lathosterol.
DR PRO; PR:O17397; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00018718; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; O17397; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0000246; F:delta24(24-1) sterol reductase activity; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0008202; P:steroid metabolic process; IBA:GO_Central.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR040165; Diminuto-like.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR10801; PTHR10801; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..525
FT /note="Diminuto-like protein"
FT /id="PRO_0000219497"
FT DOMAIN 47..239
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00718"
SQ SEQUENCE 525 AA; 61421 MW; F4D567CCE2825928 CRC64;
MNLVDEKDEK PTRWEKCVEF IMFHFRWVFV VPFLLPLSFL FNTVFDFRNR IVHAVNSAPN
AHVRKVKHIQ EQLKEWNDNG RKSKLVNARP GWLTMSFRFP LYKENATKIA TDKLFDILDL
DVEKMTVKAE PGVTMGQLSQ YLISRGYTLP VLPELDDLTV GGLINGCGVE SGSFKYGMFQ
HICTGYEVVM SDGELKNVYP DSAAKTEQAK QDNSLFFAIP WSQGTICFLV AATIKIIPCK
KYVKLTYKKT ETLSEMCEQL TEDSDRNSEN VDFVEALMFN KEKGCIMLGE FSDGPDTHDE
VVNPIGRWYK KWFYTHVEDL INKKHESIEY IPLRDYYHRH SKSIFWELRD IVPFGNNVLF
RYLMAWMCPP KIAFLKATTP NVLRKLYDRS HVLQDMLVPL DKLEECIDLF HKEVEIYPMW
LCPFYLKSQP GLMKLRNATH KMYVDVGAYG VTSKDGYHHE RTTRRLESFV RSVNGFQMTY
ADIYMTRAEY AEMFDRTLYD WKRASCKCID AFPDIYDKIC RSGRR