DIM_CAEEL
ID DIM_CAEEL Reviewed; 640 AA.
AC Q18066; Q8MZK1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Disorganized muscle protein 1;
DE AltName: Full=2D-page protein spot 8;
GN Name=dim-1; ORFNames=C18A11.7/C18A11.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), ALTERNATIVE SPLICING,
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12663531; DOI=10.1093/genetics/163.3.905;
RA Rogalski T.M., Gilbert M.M., Devenport D., Norman K.R., Moerman D.G.;
RT "DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis
RT elegans, is necessary for maintaining bodywall muscle integrity.";
RL Genetics 163:905-915(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP PROTEIN SEQUENCE OF 318-327 (ISOFORM B), AND CLEAVAGE OF INITIATOR
RP METHIONINE.
RC STRAIN=Bristol N2;
RX PubMed=9150941; DOI=10.1002/elps.1150180337;
RA Bini L., Heid H., Liberatori S., Geier G., Pallini V., Zwilling R.;
RT "Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates
RT and identification of protein spots by microsequencing.";
RL Electrophoresis 18:557-562(1997).
CC -!- FUNCTION: Stabilizes the attachment of the myofilament lattice to the
CC muscle cell membrane. Isoform b is sufficient for wild-type function.
CC {ECO:0000269|PubMed:12663531}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12663531}.
CC Note=Localized at the basal membrane region of bodywall muscle cells.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage; Named isoforms=2;
CC Name=a; Synonyms=Long;
CC IsoId=Q18066-1; Sequence=Displayed;
CC Name=b; Synonyms=Short;
CC IsoId=Q18066-2; Sequence=VSP_009228;
CC -!- TISSUE SPECIFICITY: Expressed throughout development from the 1.5 stage
CC of embryogenesis in bodywall muscles. {ECO:0000269|PubMed:12663531}.
CC -!- PTM: The initiator methionine of isoform b is removed.
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DR EMBL; AF500489; AAM21705.1; -; mRNA.
DR EMBL; AY095447; AAM23316.1; -; mRNA.
DR EMBL; FO080602; CCD65066.1; -; Genomic_DNA.
DR EMBL; FO080602; CCD65067.1; -; Genomic_DNA.
DR PIR; H89581; H89581.
DR RefSeq; NP_001024420.1; NM_001029249.4. [Q18066-1]
DR RefSeq; NP_001024421.1; NM_001029250.4. [Q18066-2]
DR AlphaFoldDB; Q18066; -.
DR SMR; Q18066; -.
DR BioGRID; 45985; 59.
DR IntAct; Q18066; 6.
DR STRING; 6239.C18A11.7a; -.
DR iPTMnet; Q18066; -.
DR World-2DPAGE; 0020:Q18066; -.
DR EPD; Q18066; -.
DR PaxDb; Q18066; -.
DR PeptideAtlas; Q18066; -.
DR EnsemblMetazoa; C18A11.7a.1; C18A11.7a.1; WBGene00001000. [Q18066-1]
DR EnsemblMetazoa; C18A11.7b.1; C18A11.7b.1; WBGene00001000. [Q18066-2]
DR GeneID; 181062; -.
DR KEGG; cel:CELE_C18A11.7; -.
DR UCSC; C18A11.7b.1; c. elegans. [Q18066-1]
DR CTD; 181062; -.
DR WormBase; C18A11.7a; CE27706; WBGene00001000; dim-1.
DR WormBase; C18A11.7b; CE04038; WBGene00001000; dim-1.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT00940000169746; -.
DR HOGENOM; CLU_427760_0_0_1; -.
DR InParanoid; Q18066; -.
DR OrthoDB; 781030at2759; -.
DR PhylomeDB; Q18066; -.
DR PRO; PR:Q18066; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001000; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF07679; I-set; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Cytoplasm; Direct protein sequencing;
KW Disulfide bond; Immunoglobulin domain; Reference proteome; Repeat.
FT CHAIN 1..640
FT /note="Disorganized muscle protein 1"
FT /id="PRO_0000072679"
FT DOMAIN 323..417
FT /note="Ig-like C2-type 1"
FT DOMAIN 422..521
FT /note="Ig-like C2-type 2"
FT DOMAIN 529..626
FT /note="Ig-like C2-type 3"
FT REGION 154..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 343..399
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..316
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:12663531"
FT /id="VSP_009228"
SQ SEQUENCE 640 AA; 71850 MW; 8322E13E4D2C3097 CRC64;
MASLAPFFKI SDSILADESF DDLEINNHFK CTSKDLNEYP RTSTPLPGEI TSIYSLPRSY
NNQNLCTRSK PTTFISQNQQ KGMTEKPKHS EYFLRLMKTR QEMQKKLTAK NGSNKSVQQY
LRKLPPSTSK EVTIIPVKMK PDDNSVYISK ELSDRTDTKL PKVSTKEVEK FGEQSDDEER
HERSHIASDF NQKTPQSTHA TSNHRKRIFI GRTGAKQQHV SKKATESELP YNIDVSTSNT
TNATEALKLL KRPLLLPSKD PRSSKMPRLD LNQHQFRCKQ YIVHSQFTCT QIEKTFKCRV
GTSTESEDLD DYYFDAMPDG KAPHFPQQPV ARQNDDGSLE LECFVDANPT PQVKWYYDNK
EVENSGRFSA NLANKGSDSY SAILTIKELA DADAGAYRCA IVNPHGKGNA NFNLKLTGFS
SPTFVEKPQI SSRDDGQVMV MEFRAKSILE PTFVWQKLVG GGAEEIIANS DRIKAVKKLE
AGNVYYSALE IKEPTKDKDA GQFICTVKNE SGKLTATFTV KFEVPEGAPS FTRKPQILQQ
TSAGGEPAIC FDIGYSARMN PQVTWISPKS KKMKESSRIK FKTNDEGNGN FTAQLELTNY
KAKDSGTYTC NIKNDAGEAN VELTLNIEGP LDDYADDSEN
