DIN1_CAEEL
ID DIN1_CAEEL Reviewed; 2407 AA.
AC G5EGK6; E1B6R6; G5EBT0; G5ED50; G5EDA4; G5EEE3; Q8I124;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Daf-12-interacting protein 1 {ECO:0000312|WormBase:F07A11.6b};
GN Name=din-1 {ECO:0000312|WormBase:F07A11.6b};
GN ORFNames=F07A11.6 {ECO:0000312|WormBase:F07A11.6b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION (ISOFORM D), INTERACTION WITH DAF-12, SUBCELLULAR LOCATION,
RP ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=15314028; DOI=10.1101/gad.312604;
RA Ludewig A.H., Kober-Eisermann C., Weitzel C., Bethke A., Neubert K.,
RA Gerisch B., Hutter H., Antebi A.;
RT "A novel nuclear receptor/coregulator complex controls C. elegans lipid
RT metabolism, larval development, and aging.";
RL Genes Dev. 18:2120-2133(2004).
CC -!- FUNCTION: [Isoform d]: Probable transcriptional corepressor which
CC modulates activity of the nuclear hormone receptor daf-12 to regulate
CC the dauer diapause. {ECO:0000269|PubMed:15314028}.
CC -!- SUBUNIT: Isoform d interacts with daf-12.
CC {ECO:0000269|PubMed:15314028}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15314028}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=b {ECO:0000312|WormBase:F07A11.6b}; Synonyms=din-1LA
CC {ECO:0000303|PubMed:15314028};
CC IsoId=G5EGK6-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:F07A11.6a}; Synonyms=din-1LD
CC {ECO:0000303|PubMed:15314028};
CC IsoId=G5EGK6-2; Sequence=VSP_057866;
CC Name=c {ECO:0000312|WormBase:F07A11.6c}; Synonyms=din-1LB
CC {ECO:0000303|PubMed:15314028};
CC IsoId=G5EGK6-3; Sequence=VSP_057865;
CC Name=d {ECO:0000312|WormBase:F07A11.6d}; Synonyms=din-1S
CC {ECO:0000303|PubMed:15314028};
CC IsoId=G5EGK6-4; Sequence=VSP_057862;
CC Name=e {ECO:0000312|WormBase:F07A11.6e}; Synonyms=din-1LC
CC {ECO:0000303|PubMed:15314028};
CC IsoId=G5EGK6-5; Sequence=VSP_057864;
CC Name=f {ECO:0000312|WormBase:F07A11.6f};
CC IsoId=G5EGK6-6; Sequence=VSP_057863;
CC Name=g {ECO:0000312|WormBase:F07A11.6g};
CC IsoId=G5EGK6-7; Sequence=VSP_057861;
CC -!- TISSUE SPECIFICITY: Isoform d is widely expressed: detected in the
CC hypodermis, seam cells, intestine, somatic gonad, neurons, vulval
CC precursors, body wall muscle and pharynx.
CC {ECO:0000269|PubMed:15314028}.
CC -!- DEVELOPMENTAL STAGE: Isoforms b and d are widely expressed from
CC embryogenesis to adulthood. Isoform d is highly expressed in late L1
CC and L2 larval stages in XXX neuroendocrine cells. Isoform b is
CC expressed more highly in the embryo and the L1 larval stage.
CC {ECO:0000269|PubMed:15314028}.
CC -!- DISRUPTION PHENOTYPE: Knockout of isoform d results in defective dauer
CC formation. Eighteen percent of temperature sensitive mutants are
CC embryonic lethal. The surviving animals are small (Sma), clear (Clr),
CC uncoordinated, constipated and sterile. They display variable
CC morphological defects in the main body and pharynx.
CC {ECO:0000269|PubMed:15314028}.
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DR EMBL; BX284602; CAB54211.2; -; Genomic_DNA.
DR EMBL; BX284602; CAB54210.3; -; Genomic_DNA.
DR EMBL; BX284602; CAD57694.1; -; Genomic_DNA.
DR EMBL; BX284602; CAD57693.1; -; Genomic_DNA.
DR EMBL; BX284602; CAH60796.1; -; Genomic_DNA.
DR EMBL; BX284602; CBW48357.1; -; Genomic_DNA.
DR EMBL; BX284602; CBW48356.1; -; Genomic_DNA.
DR PIR; T20531; T20531.
DR PIR; T20532; T20532.
DR RefSeq; NP_001022068.1; NM_001026897.3.
DR RefSeq; NP_001254306.1; NM_001267377.1. [G5EGK6-6]
DR RefSeq; NP_001254307.1; NM_001267378.1. [G5EGK6-7]
DR RefSeq; NP_496484.3; NM_064083.5. [G5EGK6-2]
DR RefSeq; NP_496485.2; NM_064084.6. [G5EGK6-1]
DR RefSeq; NP_871901.1; NM_182101.3. [G5EGK6-3]
DR RefSeq; NP_871902.1; NM_182102.4. [G5EGK6-4]
DR AlphaFoldDB; G5EGK6; -.
DR SMR; G5EGK6; -.
DR STRING; 6239.F07A11.6b; -.
DR EPD; G5EGK6; -.
DR PaxDb; G5EGK6; -.
DR PeptideAtlas; G5EGK6; -.
DR PRIDE; G5EGK6; -.
DR EnsemblMetazoa; F07A11.6a.1; F07A11.6a.1; WBGene00008549. [G5EGK6-2]
DR EnsemblMetazoa; F07A11.6b.1; F07A11.6b.1; WBGene00008549. [G5EGK6-1]
DR EnsemblMetazoa; F07A11.6c.1; F07A11.6c.1; WBGene00008549. [G5EGK6-3]
DR EnsemblMetazoa; F07A11.6d.1; F07A11.6d.1; WBGene00008549. [G5EGK6-4]
DR EnsemblMetazoa; F07A11.6e.1; F07A11.6e.1; WBGene00008549. [G5EGK6-5]
DR EnsemblMetazoa; F07A11.6f.1; F07A11.6f.1; WBGene00008549. [G5EGK6-6]
DR EnsemblMetazoa; F07A11.6g.1; F07A11.6g.1; WBGene00008549. [G5EGK6-7]
DR GeneID; 174782; -.
DR KEGG; cel:CELE_F07A11.6; -.
DR UCSC; F07A11.6c; c. elegans.
DR CTD; 174782; -.
DR WormBase; F07A11.6a; CE37499; WBGene00008549; din-1. [G5EGK6-2]
DR WormBase; F07A11.6b; CE32618; WBGene00008549; din-1. [G5EGK6-1]
DR WormBase; F07A11.6c; CE32619; WBGene00008549; din-1. [G5EGK6-3]
DR WormBase; F07A11.6d; CE03148; WBGene00008549; din-1. [G5EGK6-4]
DR WormBase; F07A11.6e; CE37500; WBGene00008549; din-1. [G5EGK6-5]
DR WormBase; F07A11.6f; CE45315; WBGene00008549; din-1. [G5EGK6-6]
DR WormBase; F07A11.6g; CE45296; WBGene00008549; din-1. [G5EGK6-7]
DR eggNOG; KOG0112; Eukaryota.
DR InParanoid; G5EGK6; -.
DR OMA; RDIPHED; -.
DR OrthoDB; 367857at2759; -.
DR PRO; PR:G5EGK6; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00008549; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR010912; SPOC_met.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF07744; SPOC; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF100939; SSF100939; 1.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50917; SPOC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Nucleus; Reference proteome;
KW RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..2407
FT /note="Daf-12-interacting protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000433990"
FT DOMAIN 277..335
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 2213..2383
FT /note="SPOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00249"
FT REGION 90..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1858..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1932..1976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2077..2103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2172..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2049..2110
FT /evidence="ECO:0000255"
FT COMPBIAS 90..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..529
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1071
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1235..1264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1336..1398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1610..1653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1748..1768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1808..1829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1867..1892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2077..2100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..2221
FT /note="Missing (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_057861"
FT VAR_SEQ 1..2218
FT /note="MVQVPSTNTVKESRHVAISGLPSTLPDDRLQLHFTKFGEIQRLVRQHGNPEI
FT VLVSYMDARGALRARSTKPQFEDSIEYKISAYIPEPTQNSSMASMSSTPSSGQSSSPRN
FT AELSPQRYGDTRGAEVKSPSFRNQMEARRGGPHLSVQSQQRHSREYWPIPEFPSESTAC
FT VVYEIQSGSTPERDLFELVKKHSKRSGVPIDIQLESTTEPGWKKARVHYYRLDTDGLKA
FT DKSLILGRPPKFRVYYPTSGEQKHPQCHPSTSYAIPKLKGDHLLKASCSVHVPHLDRHS
FT PDHYRRRFESYGQVIDVDMVKSNDNKAFAVVQFTNIDDAQKALQDTNIPKPMSYQSRPS
FT HRIIIFYLPIECTNEEIMLIIRSLSDRIVDICVDWWDRSAVITLDDMEPANLLLKRMKL
FT VGRNNFGEHKVAVDFCSDRFNLYFINRKKENIEVAARSSSPTSKSENDQGSSSPSSSRD
FT RQNLHDPLQTRSSVEHHTNQEDQENNASGSDSSSDSDSEEGSSSSNEDSDEQNDVDEED
FT DEDVVSEEKRHEPEEGKSSSPGNGHRDESNGDKDHEDSSERFSQPSTSSHHETSHSPEK
FT DSEAYQSRSFSPLNYQSQSPGYEFLESKEIKQEFSPTTSSASSSDLELDMEMPDNPLTR
FT MLERMHWRPFIDVSSFVNRIDEIVELNQKARASYEKFTGRPFPKCNNDEVLSIQKIVFH
FT EPRDYYYYENPCSELEVRIRDWRKLSDTADLDDFRATDSKELGRDQPAGGRTSGRPSLD
FT ESRTNRLSFDSTHHPAELAQRSHSLCIGPMTPSTPFPTSQPLLVNTTHLPGTSQPSTSG
FT GITTPRSSQPPPLMSPVSRHNSMSSTGRPASIQTLRHQSVMFPPDVSIPPPPIPPTHDE
FT MMAPRGTPPSRRSSETMVPLRSPPFGTPIQNLLTMPIVPPPHLIAATSTGTHSVSSSAH
FT STPRHSISGTPVHCEPSNSKTSQPPTPKSRPEKVQIRHDTISKSGPSNAINALQARSQS
FT MTSGDPKKSAPSTPVVRDAGSDLVAQIMSNQPNLGLRKLPRIEKKSSALQNIQNHQPPH
FT SNANSTPSTPSTSTHQAMFKDKEKERKKKEKEKEEREREARREMKRKETKEERNKRKEM
FT ERAKRLEDERQERKREKKKERDERKKEKEKVRKKAEKEKLKKKKHRKGDSSDESDSDSN
FT DELDLDVRKSTKEMTQEEKDHQLALLLSKGGIIENLKSRRRSDKRAHDSFEKMQQKSQQ
FT RRVLIESSDDEGGKDGDKGNSSNGEESDSEKADLPPPPAPPSLSESADQRLKVLKEREK
FT GELTTSSDDEDHNDAGEIHQQRLTEDRENRKRQKSLTAYSSDEQGERKNVPKRMRRDDS
FT EDAAAKHPGWSAKDDQKQRKRKLEHRRSSEDESKKNAKRDFRDIPHEDVSDEEETEDGS
FT RSRRQSTSSTISNVTAKERKEKSGKTPLRIVPEPTGTPLLSPKILSPKHLSPKTSTSST
FT KRSSISDHENLISPRQRNRTTSSTSTATTSSKHEALSIPEKPLSPPVTAKSSVSSIDDP
FT SIRDEFSMNSAADSPMSTTGRPMVLTKAAMKAFNSTPPKKKNSSSGQHDSSSGSSSDSS
FT SSDGSTSSDDSSDDEVPKQTEPVTSIPVVASDNGSPENVVVETPSIVSQTPREPEPFTI
FT SEQSSESEPEAVPECPEASVEPQMETSQNVEPVSEEHEDSHEHGDSEVAVESQQQPLEH
FT QEEKEELENKILDVAAEHHEEQVQGDEDSVESSIPAPSDEPDPVTQAQEKSAHTLISDQ
FT ETDQAVQSIFDEEEADEFPQYPDFGISTNEKEVSGKDPHNIKPTEPLNNGHTDLLFSPS
FT SSAHASEKQSTKSEDDMEEDSELVVMEKEVPMEQVIAQEVHVPSEPSPMEEEVKLETSP
FT VPKEEPIKMEESPEQTPTPDLISNNESQDTPGAVNNHLHENHDAVQTPIQLQPASQHQV
FT AQPSPRPAVAPDSQQNGPVLVSQQSQPSPMSSQQSDMAQNLILSSKDINDLAAKLHKNP
FT EALAQATRGDCSGIFQHLLLHAQGNGQNMTPEMLQLKAAFFAQQQENEANQMMQAKMKQ
FT QTINKDRIKEQERVKRMYEENERKVEEDRREKQRKEEERQRLAAATAAATMATQKAAEA
FT LKQKQEVPRHGFQHVLSMMTPEARSLYEQFPGLSSYINRDSIGATNGVLHLPTQSIQRP
FT SSTASTSSNPPKAPLQPSASVNQNTIDPAEIEEIRVQRWFYK -> MSAEEAATVMAVA
FT SSDPNPPATSTVDLAAMLQQLQAAQAAQAAQQVPVVTTASTPNPLSNLETLLSTASLAN
FT LATGGALNPLSMLALTSSLNQSSPVYQGIARVLLTMNMGQMLATHQTSELLATMNQQET
FT LMALLAARNGLPFAMPQQNQQPQMPAQGGFAIPTVLPHMSLKRNAKDQLSVGGVSDRKK
FT SCPLHAMIGQGQQPPPPQQPMQAVAPAPPRSPSPPRKSMFENLPPEMKEKNEMFRKEIL
FT RRLDIILLEELGAEDEEDQKPDLKQIPTSEEDTDDSKADSMGAEGSAFRRILSRSSTMG
FT NNSGSPSASGTTSPSTSSSISSGPDSPPLEGEPLNSEFMDMLTEVAQKHREQSNTDALS
FT AKIVDEQSFSQ (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_057862"
FT VAR_SEQ 1..393
FT /note="Missing (in isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_057863"
FT VAR_SEQ 1..306
FT /note="Missing (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_057864"
FT VAR_SEQ 118..132
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_057865"
FT VAR_SEQ 1568..1763
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_057866"
SQ SEQUENCE 2407 AA; 269334 MW; F2064D0266DA1DA5 CRC64;
MVQVPSTNTV KESRHVAISG LPSTLPDDRL QLHFTKFGEI QRLVRQHGNP EIVLVSYMDA
RGALRARSTK PQFEDSIEYK ISAYIPEPTQ NSSMASMSST PSSGQSSSPR NAELSPQRYG
DTRGAEVKSP SFRNQMEARR GGPHLSVQSQ QRHSREYWPI PEFPSESTAC VVYEIQSGST
PERDLFELVK KHSKRSGVPI DIQLESTTEP GWKKARVHYY RLDTDGLKAD KSLILGRPPK
FRVYYPTSGE QKHPQCHPST SYAIPKLKGD HLLKASCSVH VPHLDRHSPD HYRRRFESYG
QVIDVDMVKS NDNKAFAVVQ FTNIDDAQKA LQDTNIPKPM SYQSRPSHRI IIFYLPIECT
NEEIMLIIRS LSDRIVDICV DWWDRSAVIT LDDMEPANLL LKRMKLVGRN NFGEHKVAVD
FCSDRFNLYF INRKKENIEV AARSSSPTSK SENDQGSSSP SSSRDRQNLH DPLQTRSSVE
HHTNQEDQEN NASGSDSSSD SDSEEGSSSS NEDSDEQNDV DEEDDEDVVS EEKRHEPEEG
KSSSPGNGHR DESNGDKDHE DSSERFSQPS TSSHHETSHS PEKDSEAYQS RSFSPLNYQS
QSPGYEFLES KEIKQEFSPT TSSASSSDLE LDMEMPDNPL TRMLERMHWR PFIDVSSFVN
RIDEIVELNQ KARASYEKFT GRPFPKCNND EVLSIQKIVF HEPRDYYYYE NPCSELEVRI
RDWRKLSDTA DLDDFRATDS KELGRDQPAG GRTSGRPSLD ESRTNRLSFD STHHPAELAQ
RSHSLCIGPM TPSTPFPTSQ PLLVNTTHLP GTSQPSTSGG ITTPRSSQPP PLMSPVSRHN
SMSSTGRPAS IQTLRHQSVM FPPDVSIPPP PIPPTHDEMM APRGTPPSRR SSETMVPLRS
PPFGTPIQNL LTMPIVPPPH LIAATSTGTH SVSSSAHSTP RHSISGTPVH CEPSNSKTSQ
PPTPKSRPEK VQIRHDTISK SGPSNAINAL QARSQSMTSG DPKKSAPSTP VVRDAGSDLV
AQIMSNQPNL GLRKLPRIEK KSSALQNIQN HQPPHSNANS TPSTPSTSTH QAMFKDKEKE
RKKKEKEKEE REREARREMK RKETKEERNK RKEMERAKRL EDERQERKRE KKKERDERKK
EKEKVRKKAE KEKLKKKKHR KGDSSDESDS DSNDELDLDV RKSTKEMTQE EKDHQLALLL
SKGGIIENLK SRRRSDKRAH DSFEKMQQKS QQRRVLIESS DDEGGKDGDK GNSSNGEESD
SEKADLPPPP APPSLSESAD QRLKVLKERE KGELTTSSDD EDHNDAGEIH QQRLTEDREN
RKRQKSLTAY SSDEQGERKN VPKRMRRDDS EDAAAKHPGW SAKDDQKQRK RKLEHRRSSE
DESKKNAKRD FRDIPHEDVS DEEETEDGSR SRRQSTSSTI SNVTAKERKE KSGKTPLRIV
PEPTGTPLLS PKILSPKHLS PKTSTSSTKR SSISDHENLI SPRQRNRTTS STSTATTSSK
HEALSIPEKP LSPPVTAKSS VSSIDDPSIR DEFSMNSAAD SPMSTTGRPM VLTKAAMKAF
NSTPPKKKNS SSGQHDSSSG SSSDSSSSDG STSSDDSSDD EVPKQTEPVT SIPVVASDNG
SPENVVVETP SIVSQTPREP EPFTISEQSS ESEPEAVPEC PEASVEPQME TSQNVEPVSE
EHEDSHEHGD SEVAVESQQQ PLEHQEEKEE LENKILDVAA EHHEEQVQGD EDSVESSIPA
PSDEPDPVTQ AQEKSAHTLI SDQETDQAVQ SIFDEEEADE FPQYPDFGIS TNEKEVSGKD
PHNIKPTEPL NNGHTDLLFS PSSSAHASEK QSTKSEDDME EDSELVVMEK EVPMEQVIAQ
EVHVPSEPSP MEEEVKLETS PVPKEEPIKM EESPEQTPTP DLISNNESQD TPGAVNNHLH
ENHDAVQTPI QLQPASQHQV AQPSPRPAVA PDSQQNGPVL VSQQSQPSPM SSQQSDMAQN
LILSSKDIND LAAKLHKNPE ALAQATRGDC SGIFQHLLLH AQGNGQNMTP EMLQLKAAFF
AQQQENEANQ MMQAKMKQQT INKDRIKEQE RVKRMYEENE RKVEEDRREK QRKEEERQRL
AAATAAATMA TQKAAEALKQ KQEVPRHGFQ HVLSMMTPEA RSLYEQFPGL SSYINRDSIG
ATNGVLHLPT QSIQRPSSTA STSSNPPKAP LQPSASVNQN TIDPAEIEEI RVQRWFYKHF
PMVWTGRLAL KSTEAMINLH LINGSETFLN DVLGRQVTEE NPRRDSVKIL QRLRLDNGQV
EHIYRILTNP EYACCLALSS VNNIENLKEN DTNLKSHFID YLINKKIAGI SSLGEVETKF
KSARVHVFAP GEIVNRYLSE LATSLHDYLQ NTDTRYLLIV FTNDKADPNM TGPPSVASLA
VPPVSST
