DING_SALTY
ID DING_SALTY Reviewed; 714 AA.
AC Q8ZQN7;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=ATP-dependent DNA helicase DinG {ECO:0000255|HAMAP-Rule:MF_02205};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_02205};
GN Name=dinG {ECO:0000255|HAMAP-Rule:MF_02205}; OrderedLocusNames=STM0821;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase.
CC {ECO:0000255|HAMAP-Rule:MF_02205}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_02205};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_02205};
CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000255|HAMAP-Rule:MF_02205};
CC -!- SIMILARITY: Belongs to the helicase family. DinG subfamily. Type 1 sub-
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_02205}.
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DR EMBL; AE006468; AAL19758.1; -; Genomic_DNA.
DR RefSeq; NP_459799.1; NC_003197.2.
DR RefSeq; WP_001218630.1; NC_003197.2.
DR AlphaFoldDB; Q8ZQN7; -.
DR SMR; Q8ZQN7; -.
DR STRING; 99287.STM0821; -.
DR PaxDb; Q8ZQN7; -.
DR EnsemblBacteria; AAL19758; AAL19758; STM0821.
DR GeneID; 1252341; -.
DR KEGG; stm:STM0821; -.
DR PATRIC; fig|99287.12.peg.855; -.
DR HOGENOM; CLU_012117_4_1_6; -.
DR OMA; PRRAQNY; -.
DR PhylomeDB; Q8ZQN7; -.
DR BioCyc; SENT99287:STM0821-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0033677; F:DNA/RNA helicase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0009432; P:SOS response; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_02205; DinG_proteobact; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR010614; DEAD_2.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR039000; DinG_proteobact.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11472; PTHR11472; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; ATP-binding; DNA-binding; Helicase; Hydrolase; Iron; Iron-sulfur;
KW Metal-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..714
FT /note="ATP-dependent DNA helicase DinG"
FT /id="PRO_0000102001"
FT DOMAIN 17..294
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
FT DOMAIN 517..698
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
FT MOTIF 248..251
FT /note="DEAH box"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
FT BINDING 54..61
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205, ECO:0000305"
FT BINDING 120
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
FT BINDING 194
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
FT BINDING 199
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
FT BINDING 205
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02205"
SQ SEQUENCE 714 AA; 80979 MW; A4DFA8847073C57C CRC64;
MALTAALKAQ IAAWYKALQD QIPDFIPRAP QRQMIADVAR TLAGEEGRHL AIEAPTGVGK
TLSYLIPGIA IAREEQKTLV VSTANVALQD QIFSKDLPLL RKIIPDLRFT AAFGRGRYVC
PRNLAALASS EPTQQDLLAF LDDELTPNNQ EEQKRCARLK GDLDGYKWDG LRDHTDIAID
DDLWRRLSTD KASCLNRNCH YYRECPFFVA RREIQEAEVV VANHALVMAA MESEAVLPEP
KHLLLVLDEG HHLPDVARDA LEMSAEITAS WYRLQLDLFS KLVATCMEQF RPKTTPPLAN
PERLNAHCEE VYELIASLNA ILNLYMPAAQ EAEHRFAMGE LPDEVMEICQ RLAKLTETLR
GLAESFLNDL SEKTGSHDIV RLHRVILQMN RALGMFEAQS KLWRLASMAQ SSGAPVSKWA
TREIREGQLH VWFHCVGIRV SDQLERLLWR SVPHIIVTSA TLRSLNSFSR LQEMSGLKEK
AGDRFVALDS PFNHVEQGKL VIPQMRYEPT IDNEEQHIAE MAAYFREQLE SKKHHGMLVL
FASGRAMQRF LEHVADVRLL LLVQGDQPRY RLVELHRKRV ESGERSVLVG LQSFAEGLDL
KGELLTQVHI HKIAFPPIDS PVVITEGEWL KSLNRYPFEV QSLPSASFNL IQQVGRLIRS
HACRGEVVIY DKRLLTKNYG QRLLNALPVF PIEQPAVPDV IVKPKAKPAR RRRR
