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ADCA_STRP1
ID   ADCA_STRP1              Reviewed;         515 AA.
AC   Q9A0L9; Q48ZQ7;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 2.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Zinc-binding protein AdcA;
DE   Flags: Precursor;
GN   Name=adcA; OrderedLocusNames=SPy_0714, M5005_Spy0543;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   SEQUENCE REVISION TO 127.
RA   Beres S.B., Musser J.M.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; AE004092; AAK33667.2; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51161.1; -; Genomic_DNA.
DR   RefSeq; NP_268946.2; NC_002737.2.
DR   AlphaFoldDB; Q9A0L9; -.
DR   SMR; Q9A0L9; -.
DR   STRING; 1314.HKU360_00553; -.
DR   PaxDb; Q9A0L9; -.
DR   EnsemblBacteria; AAK33667; AAK33667; SPy_0714.
DR   KEGG; spy:SPy_0714; -.
DR   KEGG; spz:M5005_Spy0543; -.
DR   PATRIC; fig|160490.10.peg.608; -.
DR   HOGENOM; CLU_016838_7_1_9; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR006129; AdhesinB.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR006128; Lipoprotein_4.
DR   InterPro; IPR015304; ZinT_dom.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF09223; ZinT; 1.
DR   Pfam; PF01297; ZnuA; 1.
DR   PRINTS; PR00691; ADHESINB.
DR   PRINTS; PR00690; ADHESNFAMILY.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   3: Inferred from homology;
KW   Ion transport; Reference proteome; Signal; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..515
FT                   /note="Zinc-binding protein AdcA"
FT                   /id="PRO_0000031868"
FT   REGION          125..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        367
FT                   /note="D -> N (in Ref. 3; AAZ51161)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   515 AA;  58560 MW;  4082F86729ABF901 CRC64;
     MKKKILLMMS LISVFFAWQL TQAKQVLAEG KVKVVTTFYP VYEFTKGVIG NDGDVFMLMK
     AGTEPHDFEP STKDIKKIQD ADAFVYMDDN METWVSDVKK SLTSKKVTIV KGTGNMLLVA
     GAGHDHHHED ADKKHEHNKH SEEGHNHAFD PHVWLSPYRS ITVVENIRDS LSKAYPEKAE
     NFKANAATYI EKLKELDKDY TAALSDAKQK SFVTQHAAFG YMALDYGLNQ ISINGVTPDA
     EPSAKRIATL SKYVKKYGIK YIYFEENASS KVAKTLAKEA GVKAAVLSPL EGLTEKEMKA
     GQDYFTVMRK NLETLRLTTD VAGKEILPEK DTTKTVYNGY FKDKEVKDRQ LSDWSGSWQS
     VYPYLQDGTL DQVWDYKAKK SKGKMTAAEY KDYYTTGYKT DVEQIKINGK KKTMTFVRNG
     EKKTFTYTYA GKEILTYPKG NRGVRFMFEA KEADAGEFKY VQFSDHAIAP EKAKHFHLYW
     GGDSQEKLHK ELEHWPTYYG SDLSGREIAQ EINAH
 
 
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