ADCA_STRP1
ID ADCA_STRP1 Reviewed; 515 AA.
AC Q9A0L9; Q48ZQ7;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2015, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Zinc-binding protein AdcA;
DE Flags: Precursor;
GN Name=adcA; OrderedLocusNames=SPy_0714, M5005_Spy0543;
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN [2]
RP SEQUENCE REVISION TO 127.
RA Beres S.B., Musser J.M.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX PubMed=16088826; DOI=10.1086/432514;
RA Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA Musser J.M.;
RT "Evolutionary origin and emergence of a highly successful clone of serotype
RT M1 group A Streptococcus involved multiple horizontal gene transfer
RT events.";
RL J. Infect. Dis. 192:771-782(2005).
CC -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC {ECO:0000305}.
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DR EMBL; AE004092; AAK33667.2; -; Genomic_DNA.
DR EMBL; CP000017; AAZ51161.1; -; Genomic_DNA.
DR RefSeq; NP_268946.2; NC_002737.2.
DR AlphaFoldDB; Q9A0L9; -.
DR SMR; Q9A0L9; -.
DR STRING; 1314.HKU360_00553; -.
DR PaxDb; Q9A0L9; -.
DR EnsemblBacteria; AAK33667; AAK33667; SPy_0714.
DR KEGG; spy:SPy_0714; -.
DR KEGG; spz:M5005_Spy0543; -.
DR PATRIC; fig|160490.10.peg.608; -.
DR HOGENOM; CLU_016838_7_1_9; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR006129; AdhesinB.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR006128; Lipoprotein_4.
DR InterPro; IPR015304; ZinT_dom.
DR InterPro; IPR006127; ZnuA-like.
DR Pfam; PF09223; ZinT; 1.
DR Pfam; PF01297; ZnuA; 1.
DR PRINTS; PR00691; ADHESINB.
DR PRINTS; PR00690; ADHESNFAMILY.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 3: Inferred from homology;
KW Ion transport; Reference proteome; Signal; Transport; Zinc; Zinc transport.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..515
FT /note="Zinc-binding protein AdcA"
FT /id="PRO_0000031868"
FT REGION 125..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 367
FT /note="D -> N (in Ref. 3; AAZ51161)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 515 AA; 58560 MW; 4082F86729ABF901 CRC64;
MKKKILLMMS LISVFFAWQL TQAKQVLAEG KVKVVTTFYP VYEFTKGVIG NDGDVFMLMK
AGTEPHDFEP STKDIKKIQD ADAFVYMDDN METWVSDVKK SLTSKKVTIV KGTGNMLLVA
GAGHDHHHED ADKKHEHNKH SEEGHNHAFD PHVWLSPYRS ITVVENIRDS LSKAYPEKAE
NFKANAATYI EKLKELDKDY TAALSDAKQK SFVTQHAAFG YMALDYGLNQ ISINGVTPDA
EPSAKRIATL SKYVKKYGIK YIYFEENASS KVAKTLAKEA GVKAAVLSPL EGLTEKEMKA
GQDYFTVMRK NLETLRLTTD VAGKEILPEK DTTKTVYNGY FKDKEVKDRQ LSDWSGSWQS
VYPYLQDGTL DQVWDYKAKK SKGKMTAAEY KDYYTTGYKT DVEQIKINGK KKTMTFVRNG
EKKTFTYTYA GKEILTYPKG NRGVRFMFEA KEADAGEFKY VQFSDHAIAP EKAKHFHLYW
GGDSQEKLHK ELEHWPTYYG SDLSGREIAQ EINAH