ID   ADCA_STRP3              Reviewed;         515 AA.
AC   P0DF58; Q8K847;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Zinc-binding protein AdcA;
DE   Flags: Precursor;
GN   Name=adcA; OrderedLocusNames=SpyM3_0466;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; AE014074; AAM79073.1; -; Genomic_DNA.
DR   RefSeq; WP_011054319.1; NC_004070.1.
DR   AlphaFoldDB; P0DF58; -.
DR   SMR; P0DF58; -.
DR   EnsemblBacteria; AAM79073; AAM79073; SpyM3_0466.
DR   KEGG; spg:SpyM3_0466; -.
DR   HOGENOM; CLU_016838_7_1_9; -.
DR   OMA; ETWVPKV; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR006129; AdhesinB.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR006128; Lipoprotein_4.
DR   InterPro; IPR015304; ZinT_dom.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF09223; ZinT; 1.
DR   Pfam; PF01297; ZnuA; 1.
DR   PRINTS; PR00691; ADHESINB.
DR   PRINTS; PR00690; ADHESNFAMILY.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   3: Inferred from homology;
KW   Ion transport; Signal; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..515
FT                   /note="Zinc-binding protein AdcA"
FT                   /id="PRO_0000031869"
FT   REGION          126..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  58580 MW;  046219EA440EB18D CRC64;
     MKKKILLMMS LISVFFAWQL TQAKQVLAEG KVKVVTTFYP VYEFTKGIVG NDGDVSMLMK
     AGTEPHDFEP STKDIKKIQD ADAFVYMDDN METWVSDVKK SLTSKKVTIV KGTGNMLLVA
     GVGHDHHHEE ADKKHEHNKH SEEGHNHAFD PHVWLSPYRS ITVVENIRDS LSKAYPEKAE
     NFKANAATYI EKLKELDKDY TAALSDAKQK SFVTQHAAFG YMALDYGLNQ ISINGVIPDA
     EPSAKRIATL SKYVKKYGIK YIYFEENASS KVAKTLAKEA GVKAAVLSPL EGLTEKEMKA
     GQDYFTVMRK NLETLRLTTD VAGKEILPEK DTTKTVYNGY FKDKEVKDRQ LSDWSGSWQS
     VYPYLQDGTL DQVWDYKAKK SKGKMTAAEY KDYYTTGYKT DVEQIKINGK KKTMTFVRNG
     EKKTFTYTYA GKEILTYPKG NRGVRFMFEA KEPNAGEFKY VQFSDHAIAP EKAEHFHLYW
     GGDSQEKLHK ELEHWPTYYG SDLSGREIAQ EINAH