ID   DINI_ECOLI              Reviewed;          81 AA.
AC   P0ABR1; Q47143; Q9R2Y7;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA damage-inducible protein I;
GN   Name=dinI; OrderedLocusNames=b1061, JW1048;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8682790; DOI=10.1128/jb.178.13.3854-3859.1996;
RA   Yasuda T., Nagata T., Ohmori H.;
RT   "Multicopy suppressors of the cold-sensitive phenotype of the pcsA68
RT   (dinD68) mutation in Escherichia coli.";
RL   J. Bacteriol. 178:3854-3859(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   CHARACTERIZATION.
RX   PubMed=11230150; DOI=10.1101/gad.862901;
RA   Voloshin O.N., Ramirez B.E., Bax A., Camerini-Otero R.D.;
RT   "A model for the abrogation of the SOS response by an SOS protein: a
RT   negatively charged helix in DinI mimics DNA in its interaction with RecA.";
RL   Genes Dev. 15:415-427(2001).
RN   [6]
RP   STRUCTURE BY NMR.
RX   PubMed=11152126; DOI=10.1110/ps.9.11.2161;
RA   Ramirez B.E., Voloshin O.N., Camerini-Otero R.D., Bax A.;
RT   "Solution structure of dinI provides insight into its mode of recA
RT   inactivation.";
RL   Protein Sci. 9:2161-2169(2000).
CC   -!- FUNCTION: Involved in SOS regulation. Inhibits RecA by preventing RecA
CC       to bind ssDNA. Can displace ssDNA from RecA.
CC   -!- SIMILARITY: Belongs to the DinI family. {ECO:0000305}.
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DR   EMBL; D31709; BAA06515.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC74145.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35858.2; -; Genomic_DNA.
DR   PIR; B64849; B64849.
DR   RefSeq; NP_415579.1; NC_000913.3.
DR   RefSeq; WP_001217754.1; NZ_STEB01000016.1.
DR   PDB; 1GHH; NMR; -; A=1-81.
DR   PDBsum; 1GHH; -.
DR   AlphaFoldDB; P0ABR1; -.
DR   SMR; P0ABR1; -.
DR   BioGRID; 4261873; 136.
DR   DIP; DIP-9445N; -.
DR   STRING; 511145.b1061; -.
DR   PaxDb; P0ABR1; -.
DR   PRIDE; P0ABR1; -.
DR   EnsemblBacteria; AAC74145; AAC74145; b1061.
DR   EnsemblBacteria; BAA35858; BAA35858; BAA35858.
DR   GeneID; 67414256; -.
DR   GeneID; 945022; -.
DR   KEGG; ecj:JW1048; -.
DR   KEGG; eco:b1061; -.
DR   PATRIC; fig|1411691.4.peg.1207; -.
DR   EchoBASE; EB2536; -.
DR   eggNOG; ENOG5032TF2; Bacteria.
DR   HOGENOM; CLU_139795_1_0_6; -.
DR   OMA; TPWCHSS; -.
DR   PhylomeDB; P0ABR1; -.
DR   BioCyc; EcoCyc:G6558-MON; -.
DR   EvolutionaryTrace; P0ABR1; -.
DR   PRO; PR:P0ABR1; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0019899; F:enzyme binding; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0009432; P:SOS response; IDA:EcoCyc.
DR   Gene3D; 3.30.910.10; -; 1.
DR   InterPro; IPR036687; DinI-like_sf.
DR   InterPro; IPR010391; DNA_damage-inducible_DinI-like.
DR   PANTHER; PTHR36572; PTHR36572; 1.
DR   Pfam; PF06183; DinI; 1.
DR   SUPFAM; SSF54857; SSF54857; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA damage; DNA repair; Reference proteome; SOS response.
FT   CHAIN           1..81
FT                   /note="DNA damage-inducible protein I"
FT                   /id="PRO_0000201635"
FT   STRAND          2..8
FT                   /evidence="ECO:0007829|PDB:1GHH"
FT   HELIX           17..32
FT                   /evidence="ECO:0007829|PDB:1GHH"
FT   STRAND          34..36
FT                   /evidence="ECO:0007829|PDB:1GHH"
FT   STRAND          39..47
FT                   /evidence="ECO:0007829|PDB:1GHH"
FT   STRAND          49..54
FT                   /evidence="ECO:0007829|PDB:1GHH"
FT   HELIX           57..72
FT                   /evidence="ECO:0007829|PDB:1GHH"
FT   HELIX           74..77
FT                   /evidence="ECO:0007829|PDB:1GHH"
SQ   SEQUENCE   81 AA;  8949 MW;  67B706F3741C4E65 CRC64;
     MRIEVTIAKT SPLPAGAIDA LAGELSRRIQ YAFPDNEGHV SVRYAAANNL SVIGATKEDK
     QRISEILQET WESADDWFVS E