ID   ADCA_STRP6              Reviewed;         515 AA.
AC   Q5XD15;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Zinc-binding protein AdcA;
DE   Flags: Precursor;
GN   Name=adcA; OrderedLocusNames=M6_Spy0563;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
CC   -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000003; AAT86698.1; -; Genomic_DNA.
DR   RefSeq; WP_011184350.1; NC_006086.1.
DR   AlphaFoldDB; Q5XD15; -.
DR   SMR; Q5XD15; -.
DR   EnsemblBacteria; AAT86698; AAT86698; M6_Spy0563.
DR   KEGG; spa:M6_Spy0563; -.
DR   HOGENOM; CLU_016838_7_0_9; -.
DR   OMA; ETWVPKV; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR006129; AdhesinB.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR006128; Lipoprotein_4.
DR   InterPro; IPR015304; ZinT_dom.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF09223; ZinT; 1.
DR   Pfam; PF01297; ZnuA; 1.
DR   PRINTS; PR00691; ADHESINB.
DR   PRINTS; PR00690; ADHESNFAMILY.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   3: Inferred from homology;
KW   Ion transport; Signal; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..515
FT                   /note="Zinc-binding protein AdcA"
FT                   /id="PRO_0000031870"
FT   REGION          125..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  58526 MW;  3CBEE82E21E6BCDF CRC64;
     MKKKILLMMS LISVFFAWQL TQAKQVLAEG KVKVVTTFYP VYEFTKGVIG NDGDVSMLMK
     AGTEPHDFEP STKDIKKIQD ADAFVYMDDN METWVSDVKK SLTSKKVTIV KGTGNMLLVA
     GAGHDHHHED ADKKHEHNKH SEEGHNHAFD PHVWLSPYRS ITVVENIRDS LSKAYPEKAE
     NFKANAATYI EKLKELDKDY TAALSDAKQK SFVTQHAAFG YMALDYGLNQ ISINGVTPDA
     EPSAKRIATL SKYVKKYGIK YIYFEENASS KVAKTLAKEA GVKAAVLSPL EGLTEKEMKA
     GQDYFTVMRK NLETLRLTTD VAGKEILPEK DTTKTVYNGY FKDKEVKDRQ LSDWSGSWQS
     VYPYLQDGTL DQVWDYKAKK SKGKMTAAEY KDYYTTGYKT DVEQIKINGK KKTMTFVRNG
     EKKTFTYTYA GKEILTYPKG NRGVRFMFEA KEPNAGEFKY VQFSDHAIAP EKAEHFHLYW
     GGDSQEKLHK ELEHWPTYYG SDLSGREIAQ EINAH