DIOX1_ARATH
ID DIOX1_ARATH Reviewed; 332 AA.
AC F4IY03; Q9SCJ6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Probable 2-oxoglutarate-dependent dioxygenase At3g49630;
DE EC=1.14.11.-;
GN OrderedLocusNames=At3g49630; ORFNames=T9C5.220;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00805};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|PROSITE-
CC ProRule:PRU00805};
CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB62467.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL132964; CAB62467.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78568.1; -; Genomic_DNA.
DR PIR; T46240; T46240.
DR RefSeq; NP_190532.2; NM_114823.3.
DR AlphaFoldDB; F4IY03; -.
DR SMR; F4IY03; -.
DR STRING; 3702.AT3G49630.1; -.
DR PaxDb; F4IY03; -.
DR PRIDE; F4IY03; -.
DR ProteomicsDB; 222151; -.
DR EnsemblPlants; AT3G49630.1; AT3G49630.1; AT3G49630.
DR GeneID; 824125; -.
DR Gramene; AT3G49630.1; AT3G49630.1; AT3G49630.
DR KEGG; ath:AT3G49630; -.
DR Araport; AT3G49630; -.
DR TAIR; locus:2114698; AT3G49630.
DR eggNOG; KOG0143; Eukaryota.
DR HOGENOM; CLU_010119_6_0_1; -.
DR InParanoid; F4IY03; -.
DR OMA; YRGYQRM; -.
DR OrthoDB; 755305at2759; -.
DR PRO; PR:F4IY03; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4IY03; baseline and differential.
DR Genevisible; F4IY03; AT.
DR GO; GO:0051213; F:dioxygenase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.330; -; 1.
DR InterPro; IPR026992; DIOX_N.
DR InterPro; IPR044861; IPNS-like_FE2OG_OXY.
DR InterPro; IPR027443; IPNS-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR Pfam; PF14226; DIOX_N; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT CHAIN 1..332
FT /note="Probable 2-oxoglutarate-dependent dioxygenase
FT At3g49630"
FT /id="PRO_0000428722"
FT DOMAIN 182..282
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 206
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 208
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 264
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT BINDING 272
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
SQ SEQUENCE 332 AA; 37456 MW; C4B18097CE302F96 CRC64;
MATNFKSLLP VIDISPLVVK CDDANMAEDA GVAEVVGKLD RACRDAGFFY VIGHGISEDF
IRKVRVMSHQ FFELPYEEKL KIKITPAAGY RGYQRIGLNL TNGKQDMHEA IDCYKEFKQG
KHGDIGKVME GANQWPENPQ EYKELMEEYI KLCIDLSRNI LRGISLALGG SPYEFEGKML
TDPFWIMRIL GYPGVNQENV IGCGAHTDYG LLSLINQDDD KTALQVRDLA GDWIPVIPIP
GSFVCNIGDM LKILSNGVYE STLHRVINNS PRYRVCVGFF YETNFDAAVE PLDIFKEKYP
GKGTSQVFKR VVYGEHLVHK LQTTFQNLVE HS
