ID   ADCA_STRP8              Reviewed;         515 AA.
AC   Q8P1N2;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Zinc-binding protein AdcA;
DE   Flags: Precursor;
GN   Name=adcA; OrderedLocusNames=spyM18_0781;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; AE009949; AAL97448.1; -; Genomic_DNA.
DR   RefSeq; WP_011017594.1; NC_003485.1.
DR   AlphaFoldDB; Q8P1N2; -.
DR   SMR; Q8P1N2; -.
DR   KEGG; spm:spyM18_0781; -.
DR   HOGENOM; CLU_016838_7_0_9; -.
DR   OMA; ETWVPKV; -.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR006129; AdhesinB.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR006128; Lipoprotein_4.
DR   InterPro; IPR015304; ZinT_dom.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF09223; ZinT; 1.
DR   Pfam; PF01297; ZnuA; 1.
DR   PRINTS; PR00691; ADHESINB.
DR   PRINTS; PR00690; ADHESNFAMILY.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   3: Inferred from homology;
KW   Ion transport; Signal; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..515
FT                   /note="Zinc-binding protein AdcA"
FT                   /id="PRO_0000031871"
FT   REGION          125..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  58525 MW;  8839A05AA5201E5B CRC64;
     MKKKILLMMS LISVFFAWQL TQAKQVLAEG KVKVVTTFYP VYEFTKGVIG NDGDVSMLMK
     AGTEPHDFEP STKDIKKIQD ADAFVYMDDN METWVSDVKK SLTSKKVTIV KGTGNMLLVA
     GAGHDHHHED ADKKHEHNKH SEEGHNHAFD PHVWLSPYRS ITVVENIRDS LSKAYPEKAE
     NFKANAATYI EKLKELDKDY TAALSDAKQK SFVTQHAAFG YMALDYGLNQ ISINGVTPDA
     EPSAKRIATL SKYVKKYGIK YIYFEENASS KVAKTLAKEA GVKAAVLSPL EGLTKKEMKA
     GQDYFTVMRK NLETLRLTTD VAGKEILPEK DTTKTVYNGY FKDKEVKDRQ LSDWSGSWQS
     VYPYLQDGTL DQVWDYKAKK SKGKMTAAEY KDYYTTGYKT DVEQIKINGK KKTMTFVRNG
     EKKTFTYTYA GKEILTYPKG NRGVRFMFEA KEPNAGEFKY VQFSDHAIAP EKAEHFHLYW
     GGDSQEKLHK ELEHWPTYYG SDLSGREIAQ EINAH