ID   ADCA_STRPN              Reviewed;         501 AA.
AC   O05703; Q97N86;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   18-OCT-2001, sequence version 4.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Zinc-binding lipoprotein AdcA;
DE   Flags: Precursor;
GN   Name=adcA; OrderedLocusNames=SP_2169;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC       Required for transformability (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 9 family.
CC       {ECO:0000305}.
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DR   EMBL; AE005672; AAK76223.1; -; Genomic_DNA.
DR   PIR; F95253; F95253.
DR   PIR; T46756; T46756.
DR   RefSeq; WP_000724057.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; O05703; -.
DR   SMR; O05703; -.
DR   STRING; 170187.SP_2169; -.
DR   TCDB; 3.A.1.15.3; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAK76223; AAK76223; SP_2169.
DR   KEGG; spn:SP_2169; -.
DR   eggNOG; COG0803; Bacteria.
DR   eggNOG; COG3443; Bacteria.
DR   OMA; ETWVPKV; -.
DR   PhylomeDB; O05703; -.
DR   BioCyc; SPNE170187:G1FZB-2264-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR006129; AdhesinB.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR006128; Lipoprotein_4.
DR   InterPro; IPR015304; ZinT_dom.
DR   InterPro; IPR006127; ZnuA-like.
DR   Pfam; PF09223; ZinT; 1.
DR   Pfam; PF01297; ZnuA; 1.
DR   PRINTS; PR00691; ADHESINB.
DR   PRINTS; PR00690; ADHESNFAMILY.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Competence; Ion transport; Lipoprotein; Membrane; Palmitate;
KW   Signal; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000305"
FT   CHAIN           19..501
FT                   /note="Zinc-binding lipoprotein AdcA"
FT                   /id="PRO_0000031866"
FT   REGION          116..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   501 AA;  56221 MW;  95FC60B509DC242C CRC64;
     MKKISLLLAS LCALFLVACS NQKQADGKLN IVTTFYPVYE FTKQVAGDTA NVELLIGAGT
     EPHEYEPSAK AVAKIQDADT FVYENENMET WVPKLLDTLD KKKVKTIKAT GDMLLLPGGE
     EEEGDHDHGE EGHHHEFDPH VWLSPVRAIK LVEHIRDSLS ADYPDKKETF EKNAAAYIEK
     LQALDKAYAE GLSQAKQKSF VTQHAAFNYL ALDYGLKQVA ISGLSPDAEP SAARLAELTE
     YVKKNKIAYI YFEENASQAL ANTLSKEAGV KTDVLNPLES LTEEDTKAGE NYISVMEKNL
     KALKQTTDQE GPAIEPEKAE DTKTVQNGYF EDAAVKDRTL SDYAGNWQSV YPFLEDGTFD
     QVFDYKAKLT GKMTQAEYKA YYTKGYHTDV TKINITDNTM EFVQGGQSKK YTYKYVGKKI
     LTYKKGNRGV RFLFEATDAD AGQFKYVQFS DHNVAPVKAE HFHIFFGGTS QEALFEEMDN
     WPTYYPDNLS GQEIAQEMLA H