DIPA_DROME
ID DIPA_DROME Reviewed; 106 AA.
AC P24492; O16838; O16839; O16840; O16841; O18669; Q9V8P5;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Diptericin A {ECO:0000312|FlyBase:FBgn0004240};
DE Flags: Precursor;
GN Name=DptA {ECO:0000312|FlyBase:FBgn0004240};
GN Synonyms=Dipt {ECO:0000303|PubMed:1373375},
GN Dpt {ECO:0000303|PubMed:9335607};
GN ORFNames=CG12763 {ECO:0000312|FlyBase:FBgn0004240};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=Canton-S;
RX PubMed=2125051; DOI=10.1016/s0021-9258(18)45732-8;
RA Wicker C., Reichhart J.-M., Hoffmann D., Hultmark D., Samakovlis C.,
RA Hoffmann J.A.;
RT "Insect immunity. Characterization of a Drosophila cDNA encoding a novel
RT member of the diptericin family of immune peptides.";
RL J. Biol. Chem. 265:22493-22498(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R;
RX PubMed=1373375; DOI=10.1002/j.1460-2075.1992.tb05191.x;
RA Reichhart J.-M., Meister M., Dimarcq J.-L., Zachary D., Hoffmann D.,
RA Ruiz C., Richards G., Hoffmann J.A.;
RT "Insect immunity: developmental and inducible activity of the Drosophila
RT diptericin promoter.";
RL EMBO J. 11:1469-1477(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B09, B101, B115, B137, B141, B202, B208, B222, B225, B226, B306,
RC B314, Z18, Z22, and Z24;
RX PubMed=9335607; DOI=10.1093/genetics/147.2.713;
RA Clark A.G., Wang L.;
RT "Molecular population genetics of Drosophila immune system genes.";
RL Genetics 147:713-724(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [7]
RP FUNCTION.
RX PubMed=11269502; DOI=10.1093/embo-reports/kvd073;
RA Leulier F., Rodriguez A., Khush R.S., Abrams J.M., Lemaitre B.;
RT "The Drosophila caspase Dredd is required to resist Gram-negative bacterial
RT infection.";
RL EMBO Rep. 1:353-358(2000).
CC -!- FUNCTION: Required to resist Gram-negative bacterial infections,
CC regulated by Dredd. {ECO:0000269|PubMed:11269502,
CC ECO:0000269|PubMed:2125051}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- DEVELOPMENTAL STAGE: Constitutive expression of diptericin occurs in
CC early pupae and in adults. {ECO:0000269|PubMed:1373375}.
CC -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:2125051}.
CC -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR EMBL; M55432; AAA28466.1; -; mRNA.
DR EMBL; Z11728; CAA77791.1; -; Genomic_DNA.
DR EMBL; AF019020; AAB82517.1; -; Genomic_DNA.
DR EMBL; AF019021; AAB82518.1; -; Genomic_DNA.
DR EMBL; AF019022; AAB82519.1; -; Genomic_DNA.
DR EMBL; AF019023; AAB82520.1; -; Genomic_DNA.
DR EMBL; AF019024; AAB82521.1; -; Genomic_DNA.
DR EMBL; AF019025; AAB82522.1; -; Genomic_DNA.
DR EMBL; AF019026; AAB82523.1; -; Genomic_DNA.
DR EMBL; AF019027; AAB82524.1; -; Genomic_DNA.
DR EMBL; AF019028; AAB82525.1; -; Genomic_DNA.
DR EMBL; AF019029; AAB82526.1; -; Genomic_DNA.
DR EMBL; AF019030; AAB82527.1; -; Genomic_DNA.
DR EMBL; AF019031; AAB82528.1; -; Genomic_DNA.
DR EMBL; AF019032; AAB82529.1; -; Genomic_DNA.
DR EMBL; AF019033; AAB82530.1; -; Genomic_DNA.
DR EMBL; AF019034; AAB82531.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF57619.1; -; Genomic_DNA.
DR EMBL; AY071667; AAL49289.1; -; mRNA.
DR PIR; S20878; S20878.
DR RefSeq; NP_476808.1; NM_057460.4.
DR AlphaFoldDB; P24492; -.
DR BioGRID; 62850; 1.
DR DIP; DIP-20883N; -.
DR IntAct; P24492; 1.
DR STRING; 7227.FBpp0085802; -.
DR TCDB; 1.C.115.1.1; the membrane-permeabilizing peptide, atticin (atticin) family.
DR PaxDb; P24492; -.
DR DNASU; 37183; -.
DR EnsemblMetazoa; FBtr0086620; FBpp0085802; FBgn0004240.
DR GeneID; 37183; -.
DR KEGG; dme:Dmel_CG12763; -.
DR CTD; 37183; -.
DR FlyBase; FBgn0004240; DptA.
DR VEuPathDB; VectorBase:FBgn0004240; -.
DR GeneTree; ENSGT00940000176590; -.
DR HOGENOM; CLU_168494_0_0_1; -.
DR InParanoid; P24492; -.
DR OMA; QGHEKVW; -.
DR PhylomeDB; P24492; -.
DR BioGRID-ORCS; 37183; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37183; -.
DR PRO; PR:P24492; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0004240; Expressed in arthropod fat body and 16 other tissues.
DR ExpressionAtlas; P24492; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019731; P:antibacterial humoral response; IEP:FlyBase.
DR GO; GO:0042742; P:defense response to bacterium; ISS:FlyBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEP:FlyBase.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045089; P:positive regulation of innate immune response; HMP:FlyBase.
DR GO; GO:0009617; P:response to bacterium; IDA:FlyBase.
DR GO; GO:0055093; P:response to hyperoxia; IMP:FlyBase.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Immunity; Innate immunity; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000305"
FT PROPEP 20..23
FT /note="Removed by a dipeptidylpeptidase"
FT /evidence="ECO:0000305"
FT /id="PRO_0000004908"
FT CHAIN 24..106
FT /note="Diptericin A"
FT /id="PRO_0000004909"
FT VARIANT 48
FT /note="S -> R (in strain: B306, Z18, Z22 and Z24)"
FT VARIANT 48
FT /note="S -> T (in strain: B101)"
FT VARIANT 55
FT /note="A -> G (in strain: B306, Z18 and Z22)"
FT VARIANT 65
FT /note="S -> T (in strain: Z22)"
FT VARIANT 73
FT /note="G -> R (in strain: B141)"
FT VARIANT 90
FT /note="E -> Q (in strain: Z24)"
FT VARIANT 98
FT /note="T -> N (in strain: B101)"
SQ SEQUENCE 106 AA; 11314 MW; 9C498DF4A4DECEF7 CRC64;
MQFTIAVALL CCAIASTLAY PMPDDMTMKP TPPPQYPLNL QGGGGGQSGD GFGFAVQGHQ
KVWTSDNGRH EIGLNGGYGQ HLGGPYGNSE PSWKVGSTYT YRFPNF
