ID   DIPBP_PSEAE             Reviewed;         533 AA.
AC   Q9HVS1;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Dipeptide-binding protein {ECO:0000305};
DE   Flags: Precursor;
GN   OrderedLocusNames=PA4500 {ECO:0000312|EMBL:AAG07888.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION AS A BINDING PROTEIN.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=31627455; DOI=10.3390/ijms20205156;
RA   Fernandez M., Rico-Jimenez M., Ortega A., Daddaoua A., Garcia Garcia A.I.,
RA   Martin-Mora D., Torres N.M., Tajuelo A., Matilla M.A., Krell T.;
RT   "Determination of Ligand Profiles for Pseudomonas aeruginosa Solute Binding
RT   Proteins.";
RL   Int. J. Mol. Sci. 20:5156-5156(2019).
CC   -!- FUNCTION: Binds different dipeptides. Probably bind only L-amino acid
CC       containig dipeptides. {ECO:0000269|PubMed:31627455}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG07888.1; -; Genomic_DNA.
DR   PIR; C83084; C83084.
DR   RefSeq; NP_253190.1; NC_002516.2.
DR   RefSeq; WP_003112861.1; NZ_QZGE01000004.1.
DR   AlphaFoldDB; Q9HVS1; -.
DR   SMR; Q9HVS1; -.
DR   STRING; 287.DR97_1679; -.
DR   PaxDb; Q9HVS1; -.
DR   PRIDE; Q9HVS1; -.
DR   EnsemblBacteria; AAG07888; AAG07888; PA4500.
DR   GeneID; 881062; -.
DR   KEGG; pae:PA4500; -.
DR   PATRIC; fig|208964.12.peg.4710; -.
DR   PseudoCAP; PA4500; -.
DR   HOGENOM; CLU_017028_7_0_6; -.
DR   InParanoid; Q9HVS1; -.
DR   OMA; YDFFTWE; -.
DR   PhylomeDB; Q9HVS1; -.
DR   BioCyc; PAER208964:G1FZ6-4589-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IBA:GO_Central.
DR   GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042938; P:dipeptide transport; IBA:GO_Central.
DR   GO; GO:0015833; P:peptide transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR030678; Peptide/Ni-bd.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR023765; SBP_5_CS.
DR   InterPro; IPR000914; SBP_5_dom.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   PIRSF; PIRSF002741; MppA; 1.
DR   PROSITE; PS01040; SBP_BACTERIAL_5; 1.
PE   1: Evidence at protein level;
KW   Peptide transport; Periplasm; Protein transport; Reference proteome;
KW   Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..533
FT                   /note="Dipeptide-binding protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004331147"
SQ   SEQUENCE   533 AA;  59675 MW;  F6346FEC78E23C54 CRC64;
     MRKILPLRAW LAAGLILGSP FSHAASNLVF CSEGSPAGFD PAQYTTGTDY DATSVTLFNR
     LVQFERGGTR AIPALAESWD IGDDGKTYTF HLRKGVKFHS TDYFKPTREF NADDVLFTFQ
     RMLDKNHPFR KAYPTEFPYF TDMGLDKNIA RVEKLDEHRV KFTLNEVDAA FIQNLAMDVA
     SIQSAEYAGQ LLEAGKPQQI NQKPIGTGPF ILSRYQKDAQ IRFKGNKDYW KPEDVKIDNL
     IFSINTDAAV RAQKLKAGEC QITLNPRPAD LKALQEAANL KVPSQPGFNL GYIAYNVTHK
     PFDQLEVRQA LDMAVNKQAI IDAVYQGAGQ LAVNGMPPTQ WSYDETIKDA PFDPAKAREL
     LKKAGVAEGT EITLWAMPVQ RPYNPNAKLM AEMIQADWAK IGIKARIVSY EWGEYIKRAH
     AGEHDAMLFG WTGDNGDPDN WLATLYGCDS INGNNVSKWC DAAYDKLVKA AKRVSDQDKR
     SELYKQAQHI LKEQVPITPI AHSTVYQPMS KSVHGFKISP FSRNAFYGVA NQP