ID   DIPZ_MYCBO              Reviewed;         695 AA.
AC   P59960; A0A1R3Y2G2; X2BMN3;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Protein DipZ;
GN   Name=dipZ; OrderedLocusNames=BQ2027_MB2899;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; LT708304; SIU01520.1; -; Genomic_DNA.
DR   RefSeq; NP_856544.1; NC_002945.3.
DR   RefSeq; WP_003414635.1; NC_002945.4.
DR   AlphaFoldDB; P59960; -.
DR   SMR; P59960; -.
DR   EnsemblBacteria; SIU01520; SIU01520; BQ2027_MB2899.
DR   PATRIC; fig|233413.5.peg.3182; -.
DR   OMA; GQIRYHH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:InterPro.
DR   InterPro; IPR000866; AhpC/TSA.
DR   InterPro; IPR003834; Cyt_c_assmbl_TM_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR041017; Thioredoxin_10.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   Pfam; PF02683; DsbD; 1.
DR   Pfam; PF17991; Thioredoxin_10; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..695
FT                   /note="Protein DipZ"
FT                   /id="PRO_0000079910"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          394..542
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   695 AA;  74120 MW;  16B8ADEE33FF73DA CRC64;
     MVESRRAAAA ASAYASRCGI APATSQRSLA TPPTISVPSG EGRCRCHVAR GAGRDPRRRL
     RRRRWCGRCG YHSHLTGGEF DVNRLCQQRS RERSCQLVAV PADPRPKRQR ITDVLTLALV
     GFLGGLITGI SPCILPVLPV IFFSGAQSVD AAQVAKPEGA VAVRRKRALS ATLRPYRVIG
     GLVLSFGMVT LLGSALLSVL HLPQDAIRWA ALVALVAIGA GLIFPRFEQL LEKPFSRIPQ
     KQIVTRSNGF GLGLALGVLY VPCAGPILAA IVVAGATATI GLGTVVLTAT FALGAALPLL
     FFALAGQRIA ERVGAFRRRQ REIRIATGSV TILLAVALVF DLPAALQRAI PDYTASLQQQ
     ISTGTEIREQ LNLGGIVNAQ NAQLSNCSDG AAQLESCGTA PDLKGITGWL NTPGNKPIDL
     KSLRGKVVLI DFWAYSCINC QRAIPHVVGW YQAYKDSGLA VIGVHTPEYA FEKVPGNVAK
     GAANLGISYP IALDNNYATW TNYRNRYWPA EYLIDATGTV RHIKFGEGDY NVTETLVRQL
     LNDAKPGVKL PQPSSTTTPD LTPRAALTPE TYFGVGKVVN YGGGGAYDEG SAVFDYPPSL
     AANSFALRGR WALDYQGATS DGNDAAIKLN YHAKDVYIVV GGTGTLTVVR DGKPATLPIS
     GPPTTHQVVA GDRLASETLE VRPSKGLQVF SFTYG