ID   DIP_CALVI               Reviewed;          42 AA.
AC   C0HJX9;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Diptericin {ECO:0000303|Ref.1};
DE   Flags: Fragment;
OS   Calliphora vicina (Blue blowfly) (Calliphora erythrocephala).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Calliphorinae; Calliphora.
OX   NCBI_TaxID=7373 {ECO:0000303|Ref.1};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND INDUCTION.
RC   TISSUE=Hemolymph {ECO:0000303|Ref.1};
RA   Chernysh S., Gordja N.A., Simnonenko N.P.;
RT   "Dia pause and immune response: induction of antimicrobial peptides
RT   synthesis in the blowfly, Calliphora vicina R.-D. (Diptera:
RT   Calliphoridae).";
RL   Entomol. Sci. 3:139-144(2000).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND INDUCTION.
RC   TISSUE=Hemolymph {ECO:0000303|PubMed:26177023};
RX   PubMed=26177023; DOI=10.1371/journal.pone.0130788;
RA   Chernysh S., Gordya N., Suborova T.;
RT   "Insect antimicrobial peptide complexes prevent resistance development in
RT   bacteria.";
RL   PLoS ONE 10:E0130788-E0130788(2015).
CC   -!- FUNCTION: Antimicrobial peptide active against Gram-negative bacterium
CC       E.coli and fungus N.crassa (Ref.1). Has no activity against Gram-
CC       positive bacterium M.luteus (Ref.1). Active against E.coli and, weakly,
CC       against M.luteus (PubMed:26177023). {ECO:0000269|PubMed:26177023,
CC       ECO:0000269|Ref.1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.1}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:26177023,
CC       ECO:0000269|Ref.1}.
CC   -!- MISCELLANEOUS: At least four isoforms with masses ranging from 8886.5
CC       kDa to 9029.0 kDa seem to exist. {ECO:0000269|PubMed:26177023,
CC       ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HJX9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Immunity;
KW   Innate immunity; Secreted.
FT   CHAIN           1..>42
FT                   /note="Diptericin"
FT                   /id="PRO_0000435614"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         42
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   42 AA;  4467 MW;  F2450D368520015D CRC64;
     DSKPLNLVLP KEEPPNNPQT YGGGGGSRKD DFDVVLQGAQ EV