ID   DIP_SARPE               Reviewed;          37 AA.
AC   Q9TWW2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Diptericin {ECO:0000303|PubMed:1445217};
DE   Flags: Fragment;
OS   Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Boettcherisca.
OX   NCBI_TaxID=7386;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   INDUCTION.
RC   TISSUE=Larval hemolymph {ECO:0000269|PubMed:1445217};
RX   PubMed=1445217; DOI=10.1042/bj2870573;
RA   Ishikawa M., Kubo T., Natori S.;
RT   "Purification and characterization of a diptericin homologue from
RT   Sarcophaga peregrina (flesh fly).";
RL   Biochem. J. 287:573-578(1992).
CC   -!- FUNCTION: Acute phase protein with antibacterial activity against the
CC       Gram-negative bacteria E.coli (MIC=6.25 ug/ml) and S.sonnei (MIC=12.5
CC       ug/ml). Lacks antibacterial activity against the Gram-negative bacteria
CC       P.vulgaris, P.rettgeri and P.aeruginosa, and against the Gram-positive
CC       bacteria B.subtilis, S.aureus, M.luteus, B.megaterium, C.bovis and
CC       E.cloacae. {ECO:0000269|PubMed:1445217}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1445217}.
CC   -!- TISSUE SPECIFICITY: Synthesized by the fat body and secreted into the
CC       hemolymph. {ECO:0000269|PubMed:1445217}.
CC   -!- INDUCTION: By injury to the body wall of the larva. Expression peaks at
CC       10 hours post-injury and is maintained at this level for at least 3
CC       days. {ECO:0000269|PubMed:1445217}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined MW is: 8 kDa.
CC       {ECO:0000269|PubMed:1445217}.
CC   -!- SIMILARITY: Belongs to the attacin/sarcotoxin-2 family. {ECO:0000255}.
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DR   PIR; S29113; S29113.
DR   AlphaFoldDB; Q9TWW2; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   CHAIN           1..>37
FT                   /note="Diptericin"
FT                   /id="PRO_0000365109"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         37
FT                   /evidence="ECO:0000303|PubMed:1445217"
SQ   SEQUENCE   37 AA;  3928 MW;  E3BAC8105D2DABC7 CRC64;
     DLHIPPPDNK INWPQLSGGG GGSPKTGYDI NINAQQK