ADCB_DICDI
ID ADCB_DICDI Reviewed; 617 AA.
AC Q86KB1; Q554T9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Arrestin domain-containing protein B;
GN Name=adcB; ORFNames=DDB_G0274395;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00041};
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70090.1; -; Genomic_DNA.
DR RefSeq; XP_644234.1; XM_639142.1.
DR AlphaFoldDB; Q86KB1; -.
DR SMR; Q86KB1; -.
DR STRING; 44689.DDB0267091; -.
DR PaxDb; Q86KB1; -.
DR EnsemblProtists; EAL70090; EAL70090; DDB_G0274395.
DR GeneID; 8619663; -.
DR KEGG; ddi:DDB_G0274395; -.
DR dictyBase; DDB_G0274395; adcB.
DR eggNOG; KOG1012; Eukaryota.
DR HOGENOM; CLU_443082_0_0_1; -.
DR InParanoid; Q86KB1; -.
DR OMA; FRMNCPE; -.
DR Reactome; R-DDI-844456; The NLRP3 inflammasome.
DR PRO; PR:Q86KB1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0008603; F:cAMP-dependent protein kinase regulator activity; IGI:dictyBase.
DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031210; F:phosphatidylcholine binding; IDA:dictyBase.
DR GO; GO:0001786; F:phosphatidylserine binding; IDA:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IGI:dictyBase.
DR GO; GO:0002031; P:G protein-coupled receptor internalization; IGI:dictyBase.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0106070; P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:dictyBase.
DR Gene3D; 1.10.150.50; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR013761; SAM/pointed_sf.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF81296; SSF81296; 2.
DR PROSITE; PS50004; C2; 1.
PE 3: Inferred from homology;
KW Calcium; Metal-binding; Reference proteome.
FT CHAIN 1..617
FT /note="Arrestin domain-containing protein B"
FT /id="PRO_0000363155"
FT DOMAIN 1..109
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 20
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 20
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 27
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 76
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 76
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 78
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 78
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT BINDING 84
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
SQ SEQUENCE 617 AA; 70145 MW; FBA6A903A2750900 CRC64;
MDNRGLRLFI VEGKELKGSD NGGSSSDPYV KLKFNGNSFK TETIKNTLSP VWNQSFDIGI
INVNDPNAII EVECLDWDRF GKHDSLGKVQ LPIAILREAA TFGQTDKWLN LDKKGYVRVG
FQFNPPYPLQ QHISPDGNPN IIQNQIQQQN LISSNGQLPP PVYYEPIYLK THPTVLEAEF
ILPNDLYQKT IYVTGEPVRA SLVLYVNQPI VVRSLFVSLK GKTSVCGKKQ KELIQDLRNL
LHTSIGPSSP NSQNQKVALD IGKHIYPFEF FIPKHCNSSI DGVGNYKVLY RFQFNADIVN
LPDIQLEREI TVVNIEDTVH RMTQSQIHEK CSKSPLTGGT IEMTITAPKN SYYPGEDIEL
QVHVNNSSKK KVKKIELELQ RTISIQHEKG VPTQVLKVSK NFFPKIQQNQ QSTQIVVMET
PQTLLNSIYQ SGIIKIEYKV RAVLDILDCI DLYTIFPVNI VLPDPKRVIL PNPLDELSKI
PRYIQDWTPR NLLSWLYFRM NCPEVVTSNP EFYQYCLSGN ELLSIPDTIL LEKVLKGAGT
RTTEIHNAIK IEIDRVLSVR TILKDNQLPH LIQTFENELV TFDLLSSLSS IDLSHLTSTI
GDRIRLQNAF EKLKLNN
