ID   ADCC_DICDI              Reviewed;         654 AA.
AC   Q55CH0;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Arrestin domain-containing protein C;
GN   Name=adcC; ORFNames=DDB_G0271022;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=17659086; DOI=10.1186/gb-2007-8-7-r144;
RA   Sawai S., Guan X.-J., Kuspa A., Cox E.C.;
RT   "High-throughput analysis of spatio-temporal dynamics in Dictyostelium.";
RL   Genome Biol. 8:R144.1-R144.15(2007).
CC   -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72861.1; -; Genomic_DNA.
DR   RefSeq; XP_646511.1; XM_641419.1.
DR   AlphaFoldDB; Q55CH0; -.
DR   STRING; 44689.DDB0267092; -.
DR   PaxDb; Q55CH0; -.
DR   EnsemblProtists; EAL72861; EAL72861; DDB_G0271022.
DR   GeneID; 8617472; -.
DR   KEGG; ddi:DDB_G0271022; -.
DR   dictyBase; DDB_G0271022; adcC.
DR   eggNOG; KOG3780; Eukaryota.
DR   HOGENOM; CLU_443082_0_0_1; -.
DR   InParanoid; Q55CH0; -.
DR   OMA; IVQPDPK; -.
DR   Reactome; R-DDI-844456; The NLRP3 inflammasome.
DR   PRO; PR:Q55CH0; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR   GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR   GO; GO:0008603; F:cAMP-dependent protein kinase regulator activity; IGI:dictyBase.
DR   GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR   GO; GO:0031210; F:phosphatidylcholine binding; IDA:dictyBase.
DR   GO; GO:0001786; F:phosphatidylserine binding; IDA:dictyBase.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IGI:dictyBase.
DR   GO; GO:0002031; P:G protein-coupled receptor internalization; IGI:dictyBase.
DR   GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR   GO; GO:0106070; P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:dictyBase.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 2.60.40.150; -; 1.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR011021; Arrestin-like_N.
DR   InterPro; IPR011022; Arrestin_C-like.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM01017; Arrestin_C; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF81296; SSF81296; 2.
DR   PROSITE; PS50004; C2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..654
FT                   /note="Arrestin domain-containing protein C"
FT                   /id="PRO_0000363156"
FT   DOMAIN          1..105
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   COILED          616..647
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   654 AA;  74207 MW;  0D7C4D3CBBD02ECA CRC64;
     MTQRSLKINI IEGKDLKGLD SGGVSDCYVK FKCGPISAKT EVIKKSTSPI WNYMINIGNV
     EENTLLQFEC FDWERIGNNR TMGKTQAFVS DLSSGAKRNL MDQWLRLDTK GFIRISYEFT
     PPYPLETEST NSPNLSVVGN GSSSSSSLMY NPTPVYFKPI FLPTIPSETI NNNKSTTCHF
     LIPGSVYQTR PFVCGEFVNC SLVLNVFEAR IVVRSLNLSF SGSITYKGKK QRKLVNDYRD
     LLLGFTGGVP VPNNNGNNNL TSNKVVLERG KHVFPFQFFI DKTCKSTVNL TDYKVNYYLS
     FHADIVNQPD ISASQEIKVV NLEDTVYKQT ISPINAQTSK SPLTGGNISI SCKSVKNSFY
     PGEEIELEVE VNNSSKKKIK NVDIQLNKVE YDGTDVTGTS YQLLTMTKKF YPKIKQNTAC
     KQMVVIELPS TTQCVGLIHS IAETKMIRVE YHLLVNLDIP SCVDLRLKLP ITIVQPDPKF
     ETLPNPLTEI GNLPRYVKDW SIKNFHSWVL FKKQCPDVMA LNPEFYQYNL SGSDLMQLPT
     ETLYSIFKGA GPRTQELVND LQSQIFEIKL VRNFLKELQL SNLIDYFEKQ TITWDILLQL
     NYNEIFSITD ITIGDAKRIF LKIQQIQSER QKQQEQQEQQ VVSNLEAVSL QKSE