ID   DIR22_ARATH             Reviewed;         125 AA.
AC   Q66GI2;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Dirigent protein 22;
DE            Short=AtDIR22;
GN   Name=DIR22; OrderedLocusNames=At3g13660; ORFNames=MMM17;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17590394; DOI=10.1016/j.phytochem.2007.04.042;
RA   Ralph S.G., Jancsik S., Bohlmann J.;
RT   "Dirigent proteins in conifer defense II: Extended gene discovery,
RT   phylogeny, and constitutive and stress-induced gene expression in spruce
RT   (Picea spp.).";
RL   Phytochemistry 68:1975-1991(2007).
CC   -!- FUNCTION: Dirigent proteins impart stereoselectivity on the phenoxy
CC       radical-coupling reaction, yielding optically active lignans from two
CC       molecules of coniferyl alcohol in the biosynthesis of lignans,
CC       flavonolignans, and alkaloids and thus plays a central role in plant
CC       secondary metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the plant dirigent protein family.
CC       {ECO:0000305}.
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DR   EMBL; AP001307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002686; AEE75388.1; -; Genomic_DNA.
DR   EMBL; BT015420; AAU06129.1; -; mRNA.
DR   EMBL; BT015654; AAU15153.1; -; mRNA.
DR   RefSeq; NP_187975.2; NM_112212.4.
DR   AlphaFoldDB; Q66GI2; -.
DR   SMR; Q66GI2; -.
DR   STRING; 3702.AT3G13660.1; -.
DR   PaxDb; Q66GI2; -.
DR   PRIDE; Q66GI2; -.
DR   EnsemblPlants; AT3G13660.1; AT3G13660.1; AT3G13660.
DR   GeneID; 820570; -.
DR   Gramene; AT3G13660.1; AT3G13660.1; AT3G13660.
DR   KEGG; ath:AT3G13660; -.
DR   Araport; AT3G13660; -.
DR   TAIR; locus:2091536; AT3G13660.
DR   HOGENOM; CLU_087111_5_0_1; -.
DR   InParanoid; Q66GI2; -.
DR   OMA; TKWFDPK; -.
DR   OrthoDB; 1307715at2759; -.
DR   PhylomeDB; Q66GI2; -.
DR   PRO; PR:Q66GI2; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q66GI2; baseline and differential.
DR   Genevisible; Q66GI2; AT.
DR   GO; GO:0048046; C:apoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0009699; P:phenylpropanoid biosynthetic process; IEA:UniProt.
DR   Gene3D; 2.40.480.10; -; 1.
DR   InterPro; IPR044859; Allene_oxi_cyc_Dirigent.
DR   InterPro; IPR004265; Dirigent.
DR   PANTHER; PTHR21495; PTHR21495; 1.
DR   Pfam; PF03018; Dirigent; 1.
PE   2: Evidence at transcript level;
KW   Apoplast; Glycoprotein; Reference proteome; Secreted.
FT   CHAIN           1..125
FT                   /note="Dirigent protein 22"
FT                   /id="PRO_0000422853"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        65
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  13604 MW;  3407AE9FF45CF195 CRC64;
     MIQKAVSNSS TSFGSITMTD NALTSDVPVN STVVGQSQGF YAGAAQRELG FLMAMNFAFK
     TGKYNGSTIT ILGRNTVFSK VREMTVVGGS GIFRLARGYV EARTKWFDPK TGDATVEYNC
     YVLHY