ADCC_STRPN
ID ADCC_STRPN Reviewed; 234 AA.
AC P0A2U6; O87862;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Zinc transport system ATP-binding protein AdcC;
GN Name=adcC; OrderedLocusNames=SP_2171;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [2]
RP FUNCTION.
RX PubMed=9379902; DOI=10.1046/j.1365-2958.1997.5111879.x;
RA Dintilhac A., Alloing G., Granadel C., Claverys J.-P.;
RT "Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants
RT exhibit a requirement for Zn and Mn resulting from inactivation of putative
RT ABC metal permeases.";
RL Mol. Microbiol. 25:727-739(1997).
CC -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC Required for transformability. {ECO:0000269|PubMed:9379902}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; AE005672; AAK76225.1; -; Genomic_DNA.
DR PIR; H95253; H95253.
DR RefSeq; WP_001269474.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P0A2U6; -.
DR SMR; P0A2U6; -.
DR STRING; 170187.SP_2171; -.
DR TCDB; 3.A.1.15.3; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAK76225; AAK76225; SP_2171.
DR GeneID; 60233434; -.
DR KEGG; spn:SP_2171; -.
DR eggNOG; COG1121; Bacteria.
DR OMA; GHDHVHP; -.
DR PhylomeDB; P0A2U6; -.
DR BioCyc; SPNE170187:G1FZB-2266-MON; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Competence; Ion transport; Nucleotide-binding; Transport;
KW Zinc; Zinc transport.
FT CHAIN 1..234
FT /note="Zinc transport system ATP-binding protein AdcC"
FT /id="PRO_0000091922"
FT DOMAIN 4..234
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 234 AA; 26542 MW; 2AF782EF93D5C1A0 CRC64;
MRYITVEDLS FYYDKEPVLE HINYCVDSGE FVTLTGENGA AKTTLIKASL GILQPRIGKV
AISKTNTQGK KLRIAYLPQQ IASFNAGFPS TVYEFVKSGR YPRKGWFRRL NAHDEEHIKA
SLDSVGMWEH RDKRLGSLSG GQKQRAVIAR MFASDPDVFI LDEPTTGMDA GSKNEFYELM
HHSAHHHGKA VLMITHDPEE VKDYADRNIH LVRNQDSPWR CFNVHENGQE VGHA