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ADCC_STRPN
ID   ADCC_STRPN              Reviewed;         234 AA.
AC   P0A2U6; O87862;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Zinc transport system ATP-binding protein AdcC;
GN   Name=adcC; OrderedLocusNames=SP_2171;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [2]
RP   FUNCTION.
RX   PubMed=9379902; DOI=10.1046/j.1365-2958.1997.5111879.x;
RA   Dintilhac A., Alloing G., Granadel C., Claverys J.-P.;
RT   "Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants
RT   exhibit a requirement for Zn and Mn resulting from inactivation of putative
RT   ABC metal permeases.";
RL   Mol. Microbiol. 25:727-739(1997).
CC   -!- FUNCTION: Part of the ATP-driven transport system AdcABC for zinc.
CC       Required for transformability. {ECO:0000269|PubMed:9379902}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AE005672; AAK76225.1; -; Genomic_DNA.
DR   PIR; H95253; H95253.
DR   RefSeq; WP_001269474.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A2U6; -.
DR   SMR; P0A2U6; -.
DR   STRING; 170187.SP_2171; -.
DR   TCDB; 3.A.1.15.3; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAK76225; AAK76225; SP_2171.
DR   GeneID; 60233434; -.
DR   KEGG; spn:SP_2171; -.
DR   eggNOG; COG1121; Bacteria.
DR   OMA; GHDHVHP; -.
DR   PhylomeDB; P0A2U6; -.
DR   BioCyc; SPNE170187:G1FZB-2266-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Competence; Ion transport; Nucleotide-binding; Transport;
KW   Zinc; Zinc transport.
FT   CHAIN           1..234
FT                   /note="Zinc transport system ATP-binding protein AdcC"
FT                   /id="PRO_0000091922"
FT   DOMAIN          4..234
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   234 AA;  26542 MW;  2AF782EF93D5C1A0 CRC64;
     MRYITVEDLS FYYDKEPVLE HINYCVDSGE FVTLTGENGA AKTTLIKASL GILQPRIGKV
     AISKTNTQGK KLRIAYLPQQ IASFNAGFPS TVYEFVKSGR YPRKGWFRRL NAHDEEHIKA
     SLDSVGMWEH RDKRLGSLSG GQKQRAVIAR MFASDPDVFI LDEPTTGMDA GSKNEFYELM
     HHSAHHHGKA VLMITHDPEE VKDYADRNIH LVRNQDSPWR CFNVHENGQE VGHA
 
 
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