ID   DIR9_ARATH              Reviewed;         322 AA.
AC   O80630;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Dirigent protein 9;
DE            Short=AtDIR9;
DE   Flags: Precursor;
GN   Name=DIR9; OrderedLocusNames=At2g39430; ORFNames=F12L6.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=17590394; DOI=10.1016/j.phytochem.2007.04.042;
RA   Ralph S.G., Jancsik S., Bohlmann J.;
RT   "Dirigent proteins in conifer defense II: Extended gene discovery,
RT   phylogeny, and constitutive and stress-induced gene expression in spruce
RT   (Picea spp.).";
RL   Phytochemistry 68:1975-1991(2007).
CC   -!- FUNCTION: Dirigent proteins impart stereoselectivity on the phenoxy
CC       radical-coupling reaction, yielding optically active lignans from two
CC       molecules of coniferyl alcohol in the biosynthesis of lignans,
CC       flavonolignans, and alkaloids and thus plays a central role in plant
CC       secondary metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, apoplast
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the plant dirigent protein family.
CC       {ECO:0000305}.
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DR   EMBL; AC004218; AAC27834.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09674.1; -; Genomic_DNA.
DR   EMBL; BT010722; AAR20779.1; -; mRNA.
DR   EMBL; BT011589; AAS46642.1; -; mRNA.
DR   PIR; T00553; T00553.
DR   RefSeq; NP_181475.1; NM_129501.3.
DR   AlphaFoldDB; O80630; -.
DR   SMR; O80630; -.
DR   STRING; 3702.AT2G39430.1; -.
DR   PaxDb; O80630; -.
DR   ProteomicsDB; 224124; -.
DR   EnsemblPlants; AT2G39430.1; AT2G39430.1; AT2G39430.
DR   GeneID; 818528; -.
DR   Gramene; AT2G39430.1; AT2G39430.1; AT2G39430.
DR   KEGG; ath:AT2G39430; -.
DR   Araport; AT2G39430; -.
DR   TAIR; locus:2039737; AT2G39430.
DR   eggNOG; ENOG502QQZX; Eukaryota.
DR   HOGENOM; CLU_059816_0_1_1; -.
DR   InParanoid; O80630; -.
DR   OMA; DNQHITD; -.
DR   OrthoDB; 992495at2759; -.
DR   PhylomeDB; O80630; -.
DR   PRO; PR:O80630; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O80630; baseline and differential.
DR   Genevisible; O80630; AT.
DR   GO; GO:0048046; C:apoplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0009699; P:phenylpropanoid biosynthetic process; IEA:UniProt.
DR   Gene3D; 2.40.480.10; -; 1.
DR   InterPro; IPR044859; Allene_oxi_cyc_Dirigent.
DR   InterPro; IPR004265; Dirigent.
DR   PANTHER; PTHR46215; PTHR46215; 1.
DR   Pfam; PF03018; Dirigent; 1.
PE   2: Evidence at transcript level;
KW   Apoplast; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..322
FT                   /note="Dirigent protein 9"
FT                   /id="PRO_0000422840"
SQ   SEQUENCE   322 AA;  33762 MW;  5789411FBA67CEB0 CRC64;
     MAKALHITIF LFLISSNLLA FINSARLLDE IQPQPQLVPT GQIPTVAPTE AEEEDGTDDN
     PGLATTTTTA SAVTVPAGPA EATEPLLEFF MHDVLGGSHP SARVVTGIVA QTEVNGIPFS
     KASNSIFPVD NGVPLVNSNN INSVINPNTA PLLTGLGGAQ TSTVIQNTNG NSNDALSANS
     LPFVTAGNLP PGAALQHLMF GTITVVDDEL TESHELGSAV IGRAQGFYLA SSLDGTSQTL
     SLTVLLHGEH DQHDTLDDAI SFFGVHRTAS HASQIAVIGG TGKFEHAKGY AIVETLHNQD
     NQHITDGQDT ILHFSVYLTY KA