DIRA1_MOUSE
ID DIRA1_MOUSE Reviewed; 198 AA.
AC Q91Z61;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=GTP-binding protein Di-Ras1;
DE AltName: Full=Distinct subgroup of the Ras family member 1;
DE AltName: Full=Small GTP-binding tumor suppressor 1;
DE Flags: Precursor;
GN Name=Diras1; Synonyms=Gbts1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/SvJ;
RA Gong L., Wu K.;
RT "Molecular cloning of GBTS1, a novel gene encoding a small GTP-binding
RT tumor suppressor.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Displays low GTPase activity and exists predominantly in the
CC GTP-bound form. {ECO:0000250|UniProtKB:O95057}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Di-Ras family.
CC {ECO:0000305}.
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DR EMBL; AY059640; AAL17967.1; -; mRNA.
DR EMBL; BC057556; AAH57556.1; -; mRNA.
DR CCDS; CCDS24040.1; -.
DR RefSeq; NP_660252.1; NM_145217.2.
DR RefSeq; XP_006513501.1; XM_006513438.3.
DR AlphaFoldDB; Q91Z61; -.
DR SMR; Q91Z61; -.
DR IntAct; Q91Z61; 1.
DR MINT; Q91Z61; -.
DR STRING; 10090.ENSMUSP00000055605; -.
DR iPTMnet; Q91Z61; -.
DR PhosphoSitePlus; Q91Z61; -.
DR SwissPalm; Q91Z61; -.
DR MaxQB; Q91Z61; -.
DR PaxDb; Q91Z61; -.
DR PeptideAtlas; Q91Z61; -.
DR PRIDE; Q91Z61; -.
DR ProteomicsDB; 277453; -.
DR Antibodypedia; 23037; 243 antibodies from 27 providers.
DR DNASU; 208666; -.
DR Ensembl; ENSMUST00000055125; ENSMUSP00000055605; ENSMUSG00000043670.
DR GeneID; 208666; -.
DR KEGG; mmu:208666; -.
DR UCSC; uc007gfo.1; mouse.
DR CTD; 148252; -.
DR MGI; MGI:2183442; Diras1.
DR VEuPathDB; HostDB:ENSMUSG00000043670; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000159915; -.
DR HOGENOM; CLU_041217_9_8_1; -.
DR InParanoid; Q91Z61; -.
DR OMA; MMKEVKG; -.
DR OrthoDB; 1218505at2759; -.
DR PhylomeDB; Q91Z61; -.
DR TreeFam; TF313014; -.
DR BioGRID-ORCS; 208666; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q91Z61; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q91Z61; protein.
DR Bgee; ENSMUSG00000043670; Expressed in retinal neural layer and 101 other tissues.
DR ExpressionAtlas; Q91Z61; baseline and differential.
DR Genevisible; Q91Z61; MM.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; ISO:MGI.
DR GO; GO:0003924; F:GTPase activity; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR020849; Small_GTPase_Ras-type.
DR PANTHER; PTHR24070; PTHR24070; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51421; RAS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..195
FT /note="GTP-binding protein Di-Ras1"
FT /id="PRO_0000191649"
FT PROPEP 196..198
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000370776"
FT MOTIF 36..44
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 17..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O95057"
FT BINDING 33..39
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96HU8"
FT BINDING 61..65
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96HU8"
FT BINDING 121..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O95057"
FT BINDING 151..152
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q96HU8"
FT BINDING 151
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:O95057"
FT MOD_RES 195
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000255"
FT LIPID 195
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 198 AA; 22265 MW; 2033DE94B27A5B9D CRC64;
MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT
DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLDELSPI YKLIVQIKGS VEDIPIMLVG
NKCDETQREV HTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RSVSLSVDGK
RSSKQKRADR IKGKCALM
