DIRC2_RAT
ID DIRC2_RAT Reviewed; 478 AA.
AC Q66H95;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Solute carrier family 49 member 4 {ECO:0000305};
DE AltName: Full=Disrupted in renal carcinoma protein 2 homolog;
GN Name=Slc49a4; Synonyms=Dirc2 {ECO:0000312|RGD:1310939};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Electrogenic metabolite transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- PTM: Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261,
CC generating a N-glycosylated N-terminal and a non-glycosylated C-
CC terminal fragment. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; BC081960; AAH81960.1; -; mRNA.
DR RefSeq; NP_001012017.1; NM_001012017.1.
DR AlphaFoldDB; Q66H95; -.
DR SMR; Q66H95; -.
DR STRING; 10116.ENSRNOP00000003048; -.
DR GlyGen; Q66H95; 1 site.
DR jPOST; Q66H95; -.
DR PaxDb; Q66H95; -.
DR PRIDE; Q66H95; -.
DR Ensembl; ENSRNOT00000003048; ENSRNOP00000003048; ENSRNOG00000002240.
DR GeneID; 303902; -.
DR KEGG; rno:303902; -.
DR UCSC; RGD:1310939; rat.
DR CTD; 84925; -.
DR RGD; 1310939; Slc49a4.
DR eggNOG; KOG2563; Eukaryota.
DR GeneTree; ENSGT01030000234625; -.
DR HOGENOM; CLU_023132_4_1_1; -.
DR InParanoid; Q66H95; -.
DR OMA; CLNSVTH; -.
DR OrthoDB; 702737at2759; -.
DR PhylomeDB; Q66H95; -.
DR TreeFam; TF314292; -.
DR PRO; PR:Q66H95; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000002240; Expressed in skeletal muscle tissue and 19 other tissues.
DR Genevisible; Q66H95; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..478
FT /note="Solute carrier family 49 member 4"
FT /id="PRO_0000271340"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..89
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..152
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..229
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..314
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..384
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 406..414
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..442
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 464..478
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 14..15
FT /note="Mediates lysosomal localization"
FT /evidence="ECO:0000250"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 478 AA; 52030 MW; 0996DCDABA434DEE CRC64;
MGSGWSSEEE ERQPLLGPGL GPAPGATRRG REAAAVLPAA GPSPGRVYGR RWLVLLLFSL
LAFAQGLVWN TWGPIQNSAR QAYSFTGWDI ALLVLWGPIG FLPCFAFMWL LDKRGLRITV
LLTSFLMVLG TGLRCIPVSD LTLKKRLIHG GQILNGLAGP TVMNAAPFLS TTWFSADERA
TATAIASMLS YLGGACAFLV GPLVVPAPNG TAPLLTAESS RDHIKDRIET VLYAEFGVVC
LIFSATLAYF PPRPPLPPSV AAASQRLSYR RSFCRLLSNL RFLMIALAYA IPLGVFAGWS
GVLDLILTPV HVSQVDAGWI GFWSIVGGCV VGIAMARFAD FIRGMLKLIL LLLFSGATLS
STWFTLTCLN SVTHLPLTTV TLYASCILLG VFLNSSVPIF FELFVETVYP VPEGITCGVV
TFLSNMFMGV LLFFVTFYHT ELSWFNWCLP GSCLLSLLLI LCFRESYDRL YLDVVVSV
